incredible work by the one and only @FadiniAli.

Know of internships to add? Please reach out! 😊.

🚀 The 2025 update of Biointerns is here!. A refreshed resource for #undergrad & #master’s students seeking #paid #academic #internships in #biosciences. Big thanks to @FraLotito (concept) & Antonio (maintenance) for making this possible!.

RT @TimCoorens: Very happy and excited to announce that I'll be starting my own research group at @emblebi! The group will focus on lineage….

This research was only possible thanks to the support of @wellcometrust @Hugodecaproject and those donating samples to research studies. A massive thank you also goes to the tireless work of clinical staff 🙏.

💡We hope this comprehensive map will inspire further research into human reproductive development and foster breakthroughs in reproductive disorders. The full preprint is available here

👉 Finally, we identified which endocrine disruptors and drugs could potentially alter reproductive tract development. We’re currently validating some of these effects using organoids (shoutout to @magda_mareckova @Elias_RuizMor charlotte @Dabrica !). [10/10]

👉 We also showed that intra-organ spatial regionalisation in the fallopian tube and epididymis occurs early in development. Prenatal gene expression gradients persist into adulthood, influencing sperm maturation and highlighting regions linked to ovarian cancer. [9/10].

👉 This allowed us to identify the TFs and secreted signals likely involved in ductal regionalisation. Our findings challenge the existing paradigm, revealing that thoracic, rather than lumbosacral, HOX TFs pattern the upper fallopian tubes and epididymis. [8/10]

👉 What factors regionalise the Müllerian and Wolffian ducts into distinct organs? By adapting OrganAxis from @YayonNadav, we modelled gene expression continuously along the length of these ducts to see how they are patterned into their final tissues. [7/10].

👉 How does the Müllerian duct develop and regress in males? We described the molecules and cell lineages involved in how this duct – which eventually forms the internal female reproductive tract – emerges, elongates, and regresses in males. [6/10]

👉 What drives urethral canalisation in the male external genitalia? We discovered male-biased, androgen-dependent genes and mesenchymal-epithelial interactions likely involved in this process and crucial for understanding hypospadias, affecting 1 in 125 male newborns. [5/10].

👉 With the prenatal reproductive tract being understudied and lacking markers to distinguish cell types, our multi-modal, spatially resolved approach allowed us to identify 52 reproductive-specific cell types, capturing their complex temporal and sex-specific dynamics. [4/10]

🧩 We created a cellular and anatomical map of the developing human reproductive tract across the first and second trimesters – the first of its kind – by combining scRNA-seq and scATAC-seq on ~650,000 cells with spatial transcriptomics (10x Visium and In Situ Sequencing). [3/10]

❓What drives the early differences between male and female reproductive development? And how do sex-specific reproductive organs arise prenatally? These big questions guided our study as we mapped human reproductive development in unprecedented detail. [2/10].

📢Excited to share our work on @biorxivpreprint "Spatiotemporal map of the developing human reproductive tract at single-cell resolution"! Beyond grateful to our amazing team @ceci_icoresi @LuzGarAl @roserventotormo @MarioniLab and collaborators for their contributions. 🧵[1/10].

RT @AIClubBioMed: 📢Next Thursday 7th November! . 2 fantastic talks on the theme of "AI for single-cell biology" followed by pizza and net….

RT @PengHeAtlas: I’ve opened two more positions in my lab for both junior and senior RAs—no PhD required. 🌟 Spread the word!.🔬 Dry Lab: htt….

RT @APredeus: Our team has been working on a pipeline to reliably detect bacterial reads in human RNA-seq data - incl. various single cell….

RT @anaconesa: Second day of the @SEBiBC_es conference starts with @LuzGarAl , CellphoneDB developer talking about her impressive work on c….