Did you know cell filaments love to treadmill? 🔄 They grow and shrink on opposite ends and burn energy doing it! But why? How does it drive self-organisation and bacterial division? Dive into our new publication ft. @SaricLab @nartimsoole @seamus_holden labs to find out! 🧫🔬🖥️

EMBL Heidelberg researchers found how chromosomes switch from repelling each other to becoming sticky during cell division. They saw that protein Ki-67 turn chromosomes’ surface into a liquid-like glue that helps in the formation of daughter nuclei. 🔛 https://t.co/IlwwRqHaRK

Treadmilling of cytoskeletal filaments is crucial for their functional self-organization. A study published in @NaturePhysics sheds light on the mechanism underpinning this collective organization. https://t.co/7ABvmW4Wmj

Researchers at @ISTAustria have discovered a previously unknown mechanism of active matter #SelfOrganization, crucial for bacterial #CellDivision: Misaligned filaments spontaneously "die" to create a well-organized ring structure at the center of a dividing cell.

Curious about the #BehindThePaper insights? 🫖🔥 Peek into the story behind the research here 👀👇 https://t.co/aHQ8T8vFPg

Now go read it! 📜@NaturePhysics 🔗➡️

I’m so proud of how far we’ve come with this project, thanks to the joint efforts of @ISTAustria, @UCL_IPLS, @uniofwarwick, and @CBCB_Newcastle! 💪 A big thank you to @KevinDWhitley, @radler_philipp, @nartimsoole, @seamus_holden, and @SaricLab for all the fun along the way! 😊

Takeaway: Filament mortality via treadmilling drives self-organisation into large-scale dynamic robust and responsive structures. This allows FtsZ to form Z-rings at the right place and time in bacteria, triggering cell division. 💍🔄🎯

What about division? Our model naturally produces rings under in vivo conditions, providing a quantitative explanation for B. subtilis division ring formation and its dynamics, which is vital for proper division! 🔄💍 @SaricLab 🖥️🤝🔬@seamus_holden

But how? Turns out, treadmilling takes no prisoners! ⚔️😱 Misaligned filaments that get stuck against their neighbours can’t grow but continue to shrink and eventually die ❌🟰💀 Only the aligned survive! 🧭➡️🌟

We’ve developed a simple coarse-grained model that captures the growth-shrinkage magic of these filaments ✨ and guess what… just like bacterial FtsZ in the lab, our model filaments align perfectly! 📏🔗 @SaricLab 🖥️🤝🔬@nartimsoole

I am thrilled to share the release of the Organelle Dynamics and Function Lab @ntusbs @NTUsg Super thankful to @maxgabgut, my great lab mates, amigos and mentors @Crick and everywhere 🇦🇷➡️🇬🇧➡️🇸🇬 Interested candidates get in touch, recruiting soon! https://t.co/U2JcPHYOWw #newPI😬

Group retreat with @SaricLab in Salzburg 🏔️ Science charades, moodboards and bathing archaea under the snow! ♨️☕☃️

2 beautiful days of our group retreat in the Alps. We hiked, we enjoyed silence ❄️, we enjoyed science, we cooked, we planned, we played, we 🛁 at 🌡️.

Belated and deserved celebration of @claudiobussi paper @TheCrick with cheese tower and bubbles 🫧@DimovaLab @agumangia @SaricLab @vainhilla96 note the mozzarella representing a damaged lysosome 😃🎉congratulations everyone 🥳

Healing a perforated vesicle: Molecular condensates rapidly form, triggered by the mixing of the inner (blue) and outer (pink) protein & ion solutions. Over time, the droplets form a plug that stabilizes the membrane. Simulation: © Christian Vanhille Campos @vainhilla96 @SaricLab

Membrane damage & stress response: How does a damaged lysosome heal inside the cell? A new paper in collaboration with @SaricLab & @vainhilla96 at ISTA shows that stress granules form a plug to seal the pore. @TheCrick, @Nature

Thank you very much to @alexholehouse and Stephen Plassmeyer for covering our recent work on stress granules and endomembrane damage in this excellent News and Views article in @Nature. Check it out:

#Condensates as plugs for damaged #membranes? 😯Check out this cool work lead by @maxgabgut @claudiobussi, featuring in vivo, in vitro by @DimovaLab @agumangia, and in silico by our @vainhilla96. Fun collab after a random London encounter @UCL_IPLS. 🎡@TheCrick @ISTAustria

Thrilled to see this out! Fantastic work driven by @claudiobussi in collaboration with @agumangia @DimovaLab @vainhilla96 @SaricLab We discovered a function for stress granules during membrane damage. Very relevant for #tuberculosis =ZNFX1 Thanks everyone and @ERC_Research 🙏