New paper out in @CellReports! Led by @susie_feng, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory deficits.

RT @annalinwoo: "Contribution of perineuronal nets to hyperexcitability in pilocarpine-induced status epilepticus" is now out in Epilepsia!….

RT @chamberlandlab: Dendritic inhibition terminates plateau potentials in CA1 pyramidal neurons. First preprint from the lab!. Wonderful te….

RT @JoJoLab5: I’m excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional mem….

RT @TJRyan_77: Excited to share our new study:. "Cold memories control whole-body thermoregulatory responses" . by @Andrea_MZamora, @Akaron….

RT @dlevenstein: At #Cosyne2025? Come by my poster today (47) to hear how sequential predictive learning produces a continuous neural manif….

RT @BarnaDudok: We are recruiting a postdoc - if you are looking for the next step after finishing your PhD, and interested in interneurons….

RT @Sheffield_Lab: Our latest research, led by @AntoineMadar, on what #SynapticPlasticity rules shape CA1 and CA3 representations in the hi….

RT @AllenInstitute: New hope for families battling Dravet Syndrome. Scientists have developed a new gene replacement therapy that could im….

RT @kishoreneuro: Thrilled to share this study is now out - thanks to the thoughtful and constructive reviewers for strengthening the paper….

RT @pgolshani: Very proud of this new preprint of a study by Conor Dorian and co-led by Golshani and Buonamano labs. We find that hippocamp….

RT @LMPrida: New from the lab!! 👉🏼📝@NeuroCellPress We discovered that genetically-defined neuron types in the hip….

RT @MeghaSehgal_: 📢 Excited to share our new paper out today in Nature Neuroscience! 🧠✨. We uncover how compartmentalized dendritic plastic….

RT @SuthanaLab: My research wouldn’t be possible without NIH & 🧠 Initiative funding. I will be sharing this at a congressional briefing Fe….

RT @martafilizola: Since there has been a lot of misinformation circulating since last night, I find this AAMC infographic helpful in illus….

RT @crlee94: 🧵1/ New preprint! 🧠 Loneliness is a state that is comprised of a constellation of features (drive to socialize, unpleasant sta….

This work was led by the amazing @susie_feng but was a huge team effort across the Shuman and Cai Labs!. All of the data is available online and we hope other labs will be able to utilize it to answer other questions about epileptic circuits in MEC and hippocampus.

Altogether, this work suggest that the induction of epilepsy drives a progressive disease state with circuit dysfunction that accumulates and shifts from the hippocampus to medial entorhinal cortex as cognitive impairment progresses.

In particular, the MEC cell type most impaired were "Trough-locked" cells in layer 3, which were recently characterized as predictive grid cells (. Their dysfunction suggests this cell type may be vulnerable in epilepsy and contribute to memory deficits.

But by 8 weeks after pilocarpine, the synchronization within MEC and between MEC and hippocampus became impaired. These deficits aligned with the onset of severe memory impairments, suggesting that changes in MEC may underlie progressive memory impairment in epilepsy.