Tristan Shuman
@tristanshuman
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Neuroscientist studying circuit dysfunction in epilepsy and Alzheimer's disease. Associate Professor at Icahn School of Medicine at Mount Sinai.
New York, USA
Joined March 2009
Check out new work from our lab! We developed a new way to directly control the precise timing of interneurons during behavior and found that theta phase locking is a causal mediator of seizure susceptibility in both healthy and epileptic mice.
🚨New preprint alert🚨 We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
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Showing once again that drug effects are absolutely dwarfed by context in MDD trials. These patients were recruited bc they were in crisis requiring hospitalization. Gradual return to baseline in a stable inpatient setting. How much more could ketamine have even added?
Serial intravenous ketamine infusions were not superior to midazolam in reducing depressive symptoms among inpatients with moderate to severe depression, with no significant differences in efficacy, cognitive, economic, or quality-of-life outcomes. https://t.co/OMV8TZ4urE
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See you on the dance floor! @kaymtye @tristanshuman
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Very proud of our collaborative paper with Dean Buonomano on hippocampal neural dynamics multiplexing time and working memory in a novel implicit timing and working memory task. Congrats Conor Dorian and Jiannis Taxidis!
cell.com
Dorian et al. develop a differential-delayed-non-match-to-sample (dDNMS) task for rodents. Using this olfactory working memory and implicit timing task, they demonstrate that sequential activity in...
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The 18th Science New Wave film festival starts this Friday @DCTVny ! Join us for a weekend-long celebration of science & cinema, including feature & short films, docs, experimental films, sci-fi, and projects that defy categorization. https://t.co/tSLsSVcItI
@labocine
labocine.com
Now in its 18th year, the Science New Wave Festival will be held October 17–19, 2025, at
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Just updated CaliAli—a toolkit for longitudinal tracking in calcium imaging. It now auto-chunks each session; set your desired frames-per-batch and let it handle the rest. No manual file splitting, no RAM bottlenecks. https://t.co/Mrz9uYkx8j
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🚨New preprint alert🚨 We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
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📢Friday, September 12th, is the FINAL DAY to register for the first annual New York Memory Hub conference! Register Now for a day full of talks and discussion about all things learning and memory👉 https://t.co/1UjpvdR3PN
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Don't forget to submit your Data Blitz abstract by September 5! There will be a $500 prize for the winner!
🧠Are you a trainee attending the New York Memory Hub conference in September? Apply to give a data blitz! One winner will receive a prize! Submit your abstract by Sept 5 here ➡️ https://t.co/a23E5NoygL
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#MSNseminars APPLICATIONS DEADLINE 1 week away! Senior postdocs (at U.S.-based institutes) in all fields of #Neuroscience encouraged to apply. INCREDIBLE OPPORTUNITY to share your research, visit Mount Sinai & meet w/ faculty/trainees! APPLY NOW👉 Scan QR code on poster to apply!
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🎨 Not only are we excellent scientists, but it looks like we're also quite talented artists, too! Had a blast hanging out and painting with the Cai and Shuman Labs 🖌️
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Thank you to all of the speakers who will be joining us for the first annual New York Memory Hub conference in September! It's going to be a fantastic day! Register now 👇
NOT TO MISS📢REGISTRATION IS OPEN for the annual New York Memory Hub conference! Join @IcahnMountSinai's @denisejcai @susana_mingote & @tristanshuman on Sept 26 for a day of talks & discussion about all things learning & memory. Learn More | Register Here👉 https://t.co/ME6avppcBK
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Excited for MCCS this year! Join us in November 🤓🧠
📍 Register now for #MCCS25 on November 13 & 14! Join us for talks & networking with the best and brightest in molecular and cellular cognition. Check out the link for more information and to register & submit an abstract 👉 https://t.co/MG06VRier2
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In these difficult times (all grants frozen) it is good to recognize the good that science can do. Very proud of our new paper on open-source 2P miniscopes! They can image dendrites in cortex and dentate granule neurons through an intact CA1.
nature.com
Nature Communications - Madruga and colleagues present an open-source, miniature 2-photon microscope that can fit on a mouse’s head. Using this system, the authors perform high-resolution...
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Memory researchers in New York, check this out 👇 I'm so excited for this conference! It's going to be a fantastic day of collaborative learning and discussion about all things memory 🧠
📢REGISTRATION IS NOW OPEN for the first annual New York Memory Hub conference! Join @IcahnMountSinai's @denisejcai @susana_mingote & @tristanshuman on Sept 26 for a day of talks & discussion about all things learning & memory🧠Learn More | Register Here: https://t.co/xMjsUIHXES
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My final postdoc paper from the Golshani lab is finally out! How does inhibition regulate memory-encoding pyramidal sequences? We used kHz-rate voltage imaging of mouse CA1 PV & SST cells during a working memory task with odors. https://t.co/ahKXaLxT0f
nature.com
Nature Neuroscience - Using voltage imaging, the authors show that interneurons in the hippocampus sharpen memory-encoding-activity by increasing the signal-to-noise ratio of pyramidal neuron...
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What’s better than a one-channel #Miniscope? 🥁 A TWO-CHANNEL Miniscope! Our new Miniscope2C is a dual-channel, open-source Miniscope that lets you record 2 fluorescent signals simultaneously in freely moving animals. Read the paper here: https://t.co/LchmY020Rw (1/9)
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"Contribution of perineuronal nets to hyperexcitability in pilocarpine-induced status epilepticus" is now out in Epilepsia! 🤔What's in it, you ask? We found interneurons in the mouse hippocampus develop new matrix structures called perineuronal nets after undergoing... (1/4)
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Dendritic inhibition terminates plateau potentials in CA1 pyramidal neurons First preprint from the lab! Wonderful team effort, lead by incredibly talented Lee Vaasjo (@LVaasjo) and Shawn Kotermanski https://t.co/7pJzkDHeFt
biorxiv.org
In CA1 pyramidal neurons (CA1-PYRs), plateau potentials control synaptic plasticity and the emergence of place cell identity. Here, we show that dendritic inhibition terminates plateaus in an...
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I’m excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional memories, using an internal model to infer emotional associations and memories via projections to the amygdala https://t.co/zkhSD98GlD
https://t.co/dgNBPSNj5l
nature.com
Nature - Neurons in the rodent dorsomedial prefrontal cortex encode a flexible internal model of emotion by linking directly experienced and inferred associations with aversive experiences.
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