. a bit of a "chicken vs egg" question!. You can find this open-access article here: . Many thanks to my co-authors and all of the supportive folks that have been involved!. #epilepsy #epilepsia #ecm #matrix #perineuronalnets #pnns #neuroscience. (5/5).

Interneurons are the "brakes" of the brain, balancing out excitatory activity. If they are are more active in our model, they could be forming nets to try to balance overexcitation, or the nets could be forming due to increased activity. (4/5).

. which can lead to future seizures and developing epilepsy, but exactly what happens is not fully known. These interneurons developing new nets makes them more excitable in our model- so the neurons are firing more than w/o nets, which is both exciting and new!. (3/5).

. a long and severe seizure episode called "status epilepticus". This matters a lot because as of right now, the process of developing epilepsy is still. well, sort of a black box!. We know there are changes going on in the brain after an injury. (2/5).

"Contribution of perineuronal nets to hyperexcitability in pilocarpine-induced status epilepticus" is now out in Epilepsia! . 🤔What's in it, you ask?. We found interneurons in the mouse hippocampus develop new matrix structures called perineuronal nets after undergoing. (1/4).

Dr. Tre at it again! Congrats!!.

Hi friends- if you're interested in what I've been doing for the last 6+ years, I'm defending my dissertation on July 11th at 11am! Come tune in on zoom (message me for the link!) to hear about why we think matrix structures called #perineuronalnets are important in seizing mice.

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