Thomas Zhihao Luo
@thomaszluo
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neurobiologist at @PrincetonNeuro, formerly @PiN_Harvard
Princeton, NJ
Joined November 2022
How do brain regions interact with each other to give rise to a perceptual decision? @ayjreen @julie_charlton_ and I addressed this question by recording from 8 Neuropixels probes at the same time in rats doing a decision-making task
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RT @mameister4: The unbearable slowness of being: Humans still clock in at just 10 bits/s. Even after peer review :) Share link for Neuron:….
arxiv.org
This article is about the neural conundrum behind the slowness of human behavior. The information throughput of a human being is about 10 bits/s. In comparison, our sensory systems gather data at...
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RT @OneNeuroJHU: "Ultimately, what really interests me are the important features of neural activity that make our complex thought possible….
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RT @TheBrunoCortex: 🧠👂🫰Our paper on the limitations of other sensory modalities to influence a sensory cortex is out today! 🎉. https://t.co/….
cell.com
Kato and Bruno show that, despite responding to sounds, rodent primary somatosensory cortex (S1) encodes neither the identity of pure auditory stimuli nor simultaneous auditory-tactile stimulus...
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RT @reziliusReza: We believe that we have discovered a vector calculus for neural computation in the cerebellum: work of @ma_fakharian @jus….
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RT @HistedLab: What does #neuroscience tell us about AI, and vice versa?. In this new PNAS paper, we find that real neurons' activation fun….
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RT @MattPanichello: A new, improved version of this paper is now published at !.
nature.com
Nature - By recording large populations of neurons in behaving monkeys using newly developed silicon probes, we show that intermittent periods of memorandum-specific spiking coexist with synaptic...
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Nice news article in the @_TheTransmitter by @claulopezneuro featuring recent research from the @brody_lab and Tom Mrsic-Flogel's lab on decision-making.
thetransmitter.org
Multiple brain areas synchronize their activity to help a rodent accumulate the evidence it needs to make a choice, two new studies suggest.
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RT @CellCellPress: Now online! Mechanisms of memory-supporting neuronal dynamics in hippocampal area CA3
cell.com
Evidence from behaving mice points to cellular and circuit mechanisms that underlie observed attractor dynamics in hippocampal area CA3.
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RT @DurstewitzLab: Interested in interpretable #AI foundation models for #DynamicalSystems reconstruction?.In a new paper we move into this….
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Many thanks to our co-authors @cdk007, @wynneethepooh, Sarah Jo Venditto, Laura Lynch, Sanjeev Janarthanan, @olinesn, Tim Harris, @brody_lab.
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When the rat commits to a choice before it makes a response, the moment of commitment could be detected earlier in M1 than any other regions studied, suggesting decision termination within the forebrain initiates in M1.
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We found a network of strongly correlated brain regions that include the primary motor cortex (M1), dorsomedial frontal cortex (dmFC), and anterior dorsal striatum (ADS).
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We measured interactions between up to 20 brain regions across the forebrain (median 2749 neurons/session)
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RT @kei_m_igarashi: Where in the brain is abstract map generated?.It is the lateral entorhinal cortex (LEC) and the medial prefrontal corte….
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RT @dikshagup: The capstone project of my PhD is now online 🤯 . We argue that the cortex and striatum accumulate ev….
biorxiv.org
Decision-making based on noisy evidence requires accumulating evidence and categorizing it to form a choice. Here we evaluate a proposed feedforward and modular mapping of this process in rats:...
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RT @tyboydmeredith: Very excited to have posted a new preprint on my PhD work in the @brody_lab where we show that rats can achieve near-op….
biorxiv.org
Rational decision-makers invest more time pursuing rewards they are more confident they will eventually receive. A series of studies have therefore used willingness to wait for delayed rewards as a...
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RT @DiegoAldarondo: Happy to see my thesis work out today in @Nature! Josh Merel @jessedmarshall @lhq20 @yuvaltassa….
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RT @EdvardMoser: Grid cells have a geometry in time! .Left-right-alternating theta sweeps in the entorhinal-hippocampal spatial map. 🧹 @ER….
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RT @constan_lab: Super proud of this tour de force preprint by @heejaesayshi. Acetylcholine demixes heterogeneous dopamine signals for lear….
biorxiv.org
Midbrain dopamine neurons promote reinforcement learning and movement vigor. A major outstanding question is how dopamine-recipient neurons in the striatum parse these heterogeneous signals. Here we...
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