Woo Lab
@thewoolab
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Official Account for Christina Woo’s Lab @HarvardCCB | chembio, protein mods, chemoproteomics, TPD | Student-run account | tweets by Christina signed CMW
Cambridge, MA
Joined April 2015
Let the spectacle astound you ✨🎭 We all love a good masquerade 😉Happy Halloween from the Woo Lab!🎃🐈⬛🍂
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She’s our greatest star of all! ⭐️ Big big congratulations to our boss 🫡
Congratulations to Dr. Christina Woo at @Harvard for receiving a Supplemental Grant! @thewoolab @HarvardCCB #DreyfusAwards
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group pic featuring our friend and colleague upstairs from the Balskus lab, Ronnie 👋🏼😄
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The lab had a fabulous science-filled day yesterday at @NESACS Boston Symposium on Organic and Bioorganic Chemistry, where Christina gave an awesome keynote on our work on CRBN🫡🌟
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While a spoonful of sugar helps the medicine go down, glycosylated PROTACs are a nifty way to metabolically control PROTAC activity 🤩🟦🍬 Check out our newest work out now is @J_A_C_S 🫡 Congrats to Chace and all authors! 💐🎉🐱 https://t.co/d2mspTJVAD
pubs.acs.org
Targeted protein degradation with compounds like proteolysis targeting chimeras (PROTACs) directs disease-associated proteins to the E3 ligase ubiquitin-proteasome system for removal. However,...
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Our evolved and engineered CRBN derivative used to enrich and visualise C-term cyclic imide-containing proteins, aka "Cerebody," is now live and in stereo in @CellChemBiol!🫡🎉💛 Congratulations to everyone behind this cool work! Huzzah!
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Three cheers for Christina, who was named one of this year’s Arthur C. Cope Scholar Awardees! God, she’s brilliant! ⭐️🎉🫡
The Division of Organic Chemistry would like to congratulate the 2025 Arthur C. Cope Awardee - Prof. Timothy Swager (MIT) and the Arthur C. Cope Scholar Awardees!
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We hope everyone is as in love with this cover as we are! 🤩
💚My New Cover for @thewoolab @Harvard 💙 This art illustrates the discovery that #cereblon, a key protein in the cell’s waste disposal system, recognizes small chemical tags called #cyclic_imides (shown here in green at the tips of proteins). These naturally form at the end of
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The Woo lab has minted another Ph.D, and the lab’s first-ever PhD for the @chemical_phd program! Congratulations Dr. Farah Kabir on a brilliant dissertation ✨ Best of luck for the road ahead! 💐🧗🏽♀️🎱❤️
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Three cheers for Ethan and Hannah, who presented our two-part story of cyclic imide degron formation and detection at the @HarvardCCB Symposium today! 🥳🤩🎊
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Check out our lab's newest pub, live in ACS ChemBio! We report interesting CRBN-independent activities of N-alkylated lenalidomide derivatives, or "capped imides." Congrats to Farah and all of the authors! 🥳💐 https://t.co/Q1j0l02OyP
pubs.acs.org
Lenalidomide is a thalidomide derivative that engages the E3 ligase substrate receptor cereblon (CRBN) to promote targeted protein degradation. Lenalidomide possesses a glutarimide moiety, which is...
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Woo Lab represent! Chembio in the Pub was a blast!
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Another Woo Lab Ph.D. is in the books! Congratulations to Dr. Mark Leon-Duque for a fabulous defense talk and a multifaceted Ph.D.!🫡✨🎉Good luck for what’s to come; you will be missed 🩷
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Our Class of 2025 Ph.Ds got hooded today! Congratulations and hugs to Dr. Steven Cheng (@scheng23) and Dr. Wenqing Xu 🥳🥰 🌸🌻🥂
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The Woo Lab’s very own Dicle Ezgi Eckinci wins the Hoopes Prize for her senior undergraduate thesis! Congrats Dicle 🥳🥳 @ezgi_ekinci1
Senior MCB, CPB, and Neuroscience Concentrators Receive the Thomas Temple Hoopes and Henderson Prizes @RachelleGaudet @AdamEzraCohen @HekstraLab @VMurthyLab @DulacLab @MicrobiomeTcell @JeeyunC @mlgredler @RivasElenaRivas @denic_lab @rnett42 @MaxPrigozhin
https://t.co/3TtTNBWWMf
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Cereblon (and its buddy, the cyclic imide) is Once Again in the spotlight! Excited to share the lab's latest pub, highlighting the effects of cyclic imide stereoisomers on CRBN activity! 🥳✨ Congrats to Yuka, Saki, and all the authors 🫶 https://t.co/iUNR3rbCen
pubs.rsc.org
Thalidomide, lenalidomide, and their derivatives mimic glutarimide and aspartimide protein modifications that give rise to a motif recognized by the E3 ligase substrate adapter cereblon (CRBN). These...
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Big congratulations to our second years Yuli, Xavier (@XavierBTao), and Ethan (@EthanYFeng)for passing their PhD Qualifying Exams! 🫡🥳🌟(P.S-our stock photo models ARE wearing gloves 😉)
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Meet our lab’s latest Ph.D! Big congrats to the newly-minted Dr. Steven Cheng (@scheng23), who gave a fabulous defense talk last Friday 🫡 Best of luck for the road ahead! 🟦🎼🥳✨
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Our favourite E3 ligase adapter Cereblon is in the spotlight with our newest review by Wenqing! Check it out now and learn about the various chemical biology efforts to understand and explore CRBN activity 🥳🫶⭐️ https://t.co/JguY79jv6p
pubs.acs.org
ConspectusThe E3 ligase substrate adapter cereblon (CRBN) has garnered widespread interest from the research laboratory to the clinic. CRBN was first discovered for its association with neurological...
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