Jun-An Chen 陳俊安
@theJACLab
Followers
402
Following
1K
Media
69
Statuses
401
Non-coding RNA Function during Neural Development, Degeneration, and Aging
Taipei City, Taiwan
Joined August 2017
What a great reunion with the epigenetic buddies in gifu japan.
0
0
6
RT @SeeYeunTing: Excited to learn that our story on characterizing an interbacterial protease toxin is finally out @PLOSBiology "An interba….
0
10
0
RT @AcadSinica: Breakthrough in ALS Research:Homeostasis m6A RNA Modification Opens New Opportunities for ALS Treatment and Biomarkers.http….
0
3
0
RT @AcadSinica: Tiny Peptide, Big Impact: A Hidden Regulator of Motor Neuron Development.#RNA #Biology #MolecularBi….
0
3
0
Had an inspiring visit with Hongjun Song and Guo-Li Ming @AcadSinica , followed by an enchanting excursion to Sun Moon Lake. Grateful for the insightful discussions on #RNAmodification and #organoid advance topics and technologies! ✨🔬 @UPenn_SongMing @IMBSinica
0
0
12
🧵2/2.By combining Nanopore direct RNA‑seq and @10xGenomics multiomics, we revealed chromatin remodeling and aberrant histone marks as key ALS drivers. Restoring m6A via FTOi or #AAV gene therapy in mice slowed degeneration, improved motor function and extended lifespan.
1
1
3
🧵1/2.🚀 Breakthrough in #ALS research! @YaPingYen et al. in our lab uncovered a pivotal role of m6A in #ALS, and manipulating of m6A reservoir in motor neurons significantly slow down ALS onset and progression in SOD1 mouse model!
1
8
16
8️⃣.💡 A lncRNA misread as junk….🎯 Turns out to be essential for motor neuron wiring. #Neurobiology #Micropeptide #ALS #MotorNeuron #lncRNA #Neuroscience #RegenerativeMedicine #SciTwitter 🧠🧬✨.
0
0
0
7️⃣.🔄 This study rewrites the rules of "noncoding" RNA. 🧠 Micropeptides like Sertm2 may be key regulators & therapeutic targets in neurological disease.
1
0
0
6️⃣.🧍♂️🧬 Evolutionarily conserved! The peptide’s role was validated in human iPSC-derived motor neurons too.
1
0
0
5️⃣.🧪 Reintroducing only the micropeptide Sertm2 via lentiviral vector restored correct MN subtype patterning. 🚀 That’s right: just the peptide, not the whole lncRNA.
1
0
0
4️⃣.📉 The issue? Disrupted GDNF signaling—a critical neurotrophic pathway in motor neuron development & ALS therapy research.
1
0
0
🐭 Using embryonic stem cell & mouse models, deleting Sertm2 didn’t affect all MNs—just specific subtypes. ⚠️ Result: impaired motor coordination in mice.
1
0
0
🧩 Sertm2 is highly expressed in embryonic spinal motor neurons but was long overlooked. 🧬 Hidden in plain sight within a lncRNA, it plays a key developmental role.
1
0
0
🧬 Tiny Peptide, Big Impact.🔬 A hidden micropeptide within a misannotated lncRNA is reshaping how we think about motor neuron development. We discovered a micropeptide Sertm2, encoded by a so-called noncoding RNA.
1
0
1
RT @NeuroCellPress: Online now: Single-neuron projectome reveals organization of somatosensory ascending pathways in the mouse brain https….
0
33
0
We are recruiting PIs at all levels @AcadSinica @IMBSinica, with guaranteed life-term stable intramural grant support until you retire! We dont need to make anything great again, as we have been always GREAT! .
0
10
31