Jun-An Chen 陳俊安
@theJACLab
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Non-coding RNA Function during Neural Development, Degeneration, and Aging
Taipei City, Taiwan
Joined August 2017
Our colaborator Bi-Chang @AcadSinica developed a very elegant protocol here FYI
nature.com
Nature Communications - Combining expansion microscopy (ExM) with lightsheet imaging can enable fast 3D visualisation of biological structures at high-resolution, but such approaches can be...
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✨🧬 Isotropic expansion of a whole mouse spinal cord down to the size of a dime! Now we can peer straight into motor neuron nuclei and watch all kinds of fascinating dynamics unfold. Tiny cord, giant discoveries ahead! 🚀🔬
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"A stylish woman in a beige coat walking confidently past a moving train at a modern train station.". Create images and videos in seconds with Grok Imagine.
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RT @HungLo_tw: I'm psyched to share that my PhD paper is now out in @NeuroCellPress ! It's also my first paper as both first author and cor….
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Welcome to join the 2025 @IMBSinica Frontier Seminar Series by Drs. Lynne Maquat, Andrew Carter, Susan Gottesman, Nancy Papalopulu/@PapalopuluLab , and Lin Tian/@LinTianPhD
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What a great reunion with the epigenetic buddies in gifu japan.
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RT @SeeYeunTing: Excited to learn that our story on characterizing an interbacterial protease toxin is finally out @PLOSBiology "An interba….
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RT @AcadSinica: Breakthrough in ALS Research:Homeostasis m6A RNA Modification Opens New Opportunities for ALS Treatment and Biomarkers.http….
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RT @AcadSinica: Tiny Peptide, Big Impact: A Hidden Regulator of Motor Neuron Development.#RNA #Biology #MolecularBi….
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Had an inspiring visit with Hongjun Song and Guo-Li Ming @AcadSinica , followed by an enchanting excursion to Sun Moon Lake. Grateful for the insightful discussions on #RNAmodification and #organoid advance topics and technologies! ✨🔬 @UPenn_SongMing @IMBSinica
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🧵2/2.By combining Nanopore direct RNA‑seq and @10xGenomics multiomics, we revealed chromatin remodeling and aberrant histone marks as key ALS drivers. Restoring m6A via FTOi or #AAV gene therapy in mice slowed degeneration, improved motor function and extended lifespan.
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🧵1/2.🚀 Breakthrough in #ALS research! @YaPingYen et al. in our lab uncovered a pivotal role of m6A in #ALS, and manipulating of m6A reservoir in motor neurons significantly slow down ALS onset and progression in SOD1 mouse model!
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8️⃣.💡 A lncRNA misread as junk….🎯 Turns out to be essential for motor neuron wiring. #Neurobiology #Micropeptide #ALS #MotorNeuron #lncRNA #Neuroscience #RegenerativeMedicine #SciTwitter 🧠🧬✨.
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7️⃣.🔄 This study rewrites the rules of "noncoding" RNA. 🧠 Micropeptides like Sertm2 may be key regulators & therapeutic targets in neurological disease.
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6️⃣.🧍♂️🧬 Evolutionarily conserved! The peptide’s role was validated in human iPSC-derived motor neurons too.
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5️⃣.🧪 Reintroducing only the micropeptide Sertm2 via lentiviral vector restored correct MN subtype patterning. 🚀 That’s right: just the peptide, not the whole lncRNA.
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4️⃣.📉 The issue? Disrupted GDNF signaling—a critical neurotrophic pathway in motor neuron development & ALS therapy research.
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🐭 Using embryonic stem cell & mouse models, deleting Sertm2 didn’t affect all MNs—just specific subtypes. ⚠️ Result: impaired motor coordination in mice.
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