🚨 New #preprint alert!. We're excited to share our latest work:. "Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells". 🔗

New preprint in collaboration with the Faryabi lab: Optical Looping Interactive Viewing Engine (OLIVE), a web-based tool designed for high-throughput chromatin tracing data that functions similarly to genome browsers

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🚨 New #preprint alert! We're excited to share the latest work from the brilliant Sora Yoon: "Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety"

RT @BWFPATH: Want to learn more about BWF PATH?. We'll have 4 open zooms, two next week and two after July 4, to answer questions about app….

RT @golnaz_v: 🚨 New #preprint alert!. We're excited to share our latest work:. "Single-Allele Chromatin Tracing Reveals Genomic Clustering….

RT @atishay_jay: Transcription factors (TFs) are critical drivers of cell identity and function. We found a subset of TF encoding genes tha….

@GuyNir5 ✨ This is the first chromatin tracing study in immune cells, and we're incredibly proud of the team for reaching this milestone.

@GuyNir5 🧬 Key findings:.The dominant chromatin conformation pulls Ets1 close to its super-enhancer, spatially separating it from Fli1. Deleting the super-enhancer rewires the locus, increasing Ets1–Fli1 promoter-promoter interactions.

Huge thanks to Alistair Boettiger, @GuyNir5 , Ting Wu, and their lab members for their generous help in troubleshooting the approach.

To investigate, we needed to resolve chromatin architecture at single-allele resolution in individual cells. Atishay and Yeqiao implemented ORCA (Optical Reconstruction of Chromatin Architecture)—a sub-diffraction microscopy method—that lets us walk along the chromosome.

🔍 Our question: Why are certain paralogous transcription factors—like Ets1 and Fli1—maintained in close genomic proximity across hundreds of millions of years?.

This study was a huge team effort, led by the brilliant Atishay Jay in close collaboration with Yeqiao Zhao in the Faryabi Lab, with key contributions from Arjun Raj, whose Nimbus image analysis tool was essential.

RT @globalimmuno: The recorded video of Dr. Golnaz Vahedi seminar entitled Chromatin topology at paralogous transcription factors is now av….

RT @NU_BMG_SQE: Join us today for the BMG Seminar Speaker Dr. Golnaz Vahedi! @golnaz_v Hosted by Dr. Feng Yue @yuefeng_1 .#epigenetics #chr….

RT @EvanWeberPhD: Attention T cell biologists!. New required reading from the one and only @golnaz_v on how the epigenome directs T cell fa….

RT @LabWaggoner: Review @NatImmunol @golnaz_v.The epigenetic landscape of fate decisions in T cells..

A fantastic @PennEpiInst retreat at the Academy of Natural Sciences! Some cool pics from attendees! @Marisa_S_B

RT @canna_lab: Though I thought @CytokineSociety 2024 was a great conference, and Seoul was amazing . my photobooth skills need work. Not….

RT @PennMedicine: Six Penn experts have been elected to the National Academy of Medicine for their groundbreaking contributions to cardiolo….

Thanks @CytokineSociety #cytokine2024 #KAI2024 for inviting me and putting together an outstanding scientific meeting which ended by our keynote speaker @WeissmanLab and an entertaining closing ceremony