Golnaz Vahedi
@golnaz_v
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Professor of Genetics, University of Pennsylvania
Philadelphia, PA
Joined June 2009
🚨 New #preprint alert! We're excited to share our latest work: "Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells" 🔗 https://t.co/ZwzKhjj1m6
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In this article, I share my perspective on leveraging AI and single-cell profiling to predict type 1 diabetes. It’s great to see the diverse insights contributed by other experts in the field:
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New preprint in collaboration with the Faryabi lab: Optical Looping Interactive Viewing Engine (OLIVE), a web-based tool designed for high-throughput chromatin tracing data that functions similarly to genome browsers https://t.co/pyXXvj5TCy
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🚨 New #preprint alert! We're excited to share the latest work from the brilliant Sora Yoon: "Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety" https://t.co/xxSh2gmEf6
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Want to learn more about BWF PATH? We'll have 4 open zooms, two next week and two after July 4, to answer questions about applying to PATH. Sign up at https://t.co/cvjCuki3qr to be sent the zoom links. (The signup link is right after the word "update".)
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🚨 New #preprint alert! We're excited to share our latest work: "Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells" 🔗 https://t.co/ZwzKhjj1m6
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Transcription factors (TFs) are critical drivers of cell identity and function. We found a subset of TF encoding genes that have remained clustered together over evolutionary time. In my first paper now on @biorxivpreprint, we delve into its importance https://t.co/UCiaI49GLf
biorxiv.org
In metazoans, gene duplication has given rise to paralogous transcription factors, which have functionally diversified to control cellular differentiation. While the majority of paralogous TFs are...
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To investigate, we needed to resolve chromatin architecture at single-allele resolution in individual cells. Atishay and Yeqiao implemented ORCA (Optical Reconstruction of Chromatin Architecture)—a sub-diffraction microscopy method—that lets us walk along the chromosome.
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🔍 Our question: Why are certain paralogous transcription factors—like Ets1 and Fli1—maintained in close genomic proximity across hundreds of millions of years?
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This study was a huge team effort, led by the brilliant Atishay Jay in close collaboration with Yeqiao Zhao in the Faryabi Lab, with key contributions from Arjun Raj, whose Nimbus image analysis tool was essential.
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The recorded video of Dr. Golnaz Vahedi seminar entitled Chromatin topology at paralogous transcription factors is now available at “Global Immunotalks” YouTube Channel https://t.co/EmX9jCF57K Please ask questions in the Youtube comment section for Golnaz. Hope you enjoy it!
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Join us today for the BMG Seminar Speaker Dr. Golnaz Vahedi! @golnaz_v Hosted by Dr. Feng Yue @yuefeng_1
#epigenetics #chromatin #TranscriptionFactors @NUFeinbergMed @NorthwesternMed @PennEpiInst @PennMedicine
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Attention T cell biologists! New required reading from the one and only @golnaz_v on how the epigenome directs T cell fate and function. https://t.co/CxEdT9qRY5
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Review @NatImmunol @golnaz_v The epigenetic landscape of fate decisions in T cells https://t.co/u6sWhtmfRv
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A fantastic @PennEpiInst retreat at the Academy of Natural Sciences! Some cool pics from attendees! @Marisa_S_B
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Though I thought @CytokineSociety 2024 was a great conference, and Seoul was amazing ... my photobooth skills need work. Not so for @golnaz_v, @SchwartzLab9, Kiyoshi, et al.
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Six Penn experts have been elected to the National Academy of Medicine for their groundbreaking contributions to cardiology, nursing, health justice, and more. Read more below:
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