Thali Lab
@thali_lab
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Official Twitter home for the Thali lab at the University of Vermont, USA.
Burlington, VT
Joined March 2016
Interested in doing a postdoc exploring the cell biology & biophysics of Toxoplasma motility/host cell invasion? Join us in the Ward lab! Send cover letter and CV to Gary Ward: see https://t.co/Xbkw3qeBwM for contact details and more information about who we are and what we do.
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Our new preprint on Migrate3D is online! Huge thanks to first author @MatthewKinahan1 and our gracious lab home @thali_lab. Thread follows explaining what this is all about:
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It's official! I will be starting a research group at SUNY Upstate Medical University this fall. I am overwhelmed with gratitude for my past and present scientific mentors and friends who have made this so fun and helped make me a better scientist 1/3
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Congratulations to CMB student Emily Whitaker who successfully defended her dissertation titled, "Analysis of Host Factors Involved in Regulating HIV-1-Induced Syncytium Formation." 👏👏👏
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Thali lab alumnus @DKrementsov's latest and greatest!
Our host genetics-microbiome EAE paper is finally out at PNAS! https://t.co/opDX3eb9Xh
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Thali lab alum Nate Roy's latest masterpiece!
Finally out! Big thanks to all of our amazing collaborators and to @J_Cell_Sci for a fast, fair review process in these unprecedented times.
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1/n Our work describing the adaptation of the CDC RT-qPCR assay for use with alternative Qiagen RNA extraction kits, as well as skipping the RNA extraction step entirely is live on bioRxiv. Pls retweet. #coronavirus #COVID19 #StayAtHome
https://t.co/cGK8O5lUts
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Tight uropod-to-uropod contact between two isolated syncytia. Could one of them have fusion-replenished surface CD4? (~25% of syncytia have surface CD4!) ...is this a VS? from @msymeonides, also independently observed by our grad student Emily Whitaker!
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Immunomagnetically-isolated HIV-induced T cell syncytia, an assay 15 months in the making and nearly ready for prime time! Isolation made possible by surface-expressed split-GFP in donors/targets and a whole-GFP-specific nanobody @ChromoTekGmbH @STEMCELLTech. by @msymeonides
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Thali lab alum Nathan Roy's latest work in preprint!
New work from @Roybiolab in collaboration with the Karimi lab just out on BioRxiv. Its true - CrkL is not Crk-like. Now we know which Crk isoform to target for immunotherapy. https://t.co/5Yynj4Q0Qu
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Accepted for publication in @VirusesMDPI!
Our EWI-2 preprint is now on its 4th version on @biorxivpreprint - lots of new data (and authors!) added, and currently under peer review. The new Figure 6 is a great teaser of the direction we're now headed... HIV-induced syncytia are pretty special!
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I’m happy to share this work on how cell fusion promote a cell differentiated state through plasma membrane remodeling and changes in bioenergetics. “Transcriptional reprogramming in fused cells is triggered by plasma-membrane diminution
biorxiv.org
Developing cells divide and differentiate, and in many tissues, such as bone, muscle, and placenta, cells fuse acquiring specialized functions. While it is known that fused-cells are differentiated,...
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Our EWI-2 preprint is now on its 4th version on @biorxivpreprint - lots of new data (and authors!) added, and currently under peer review. The new Figure 6 is a great teaser of the direction we're now headed... HIV-induced syncytia are pretty special!
biorxiv.org
Cell-to-cell transfer of virus particles at the Env-dependent virological synapse (VS) is a highly efficient mode of HIV-1 transmission. While cell-cell fusion could be triggered at the VS, leading...
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Yes please!
Keep your antibodies cool and safe with a Proteintech Benchtop Cooler. ❄️ Keeps vials at 0˚C or below on lab bench. ❄️ Insulating refrigerant chills samples quickly. ❄️ Interlocking feature means they can be joined. RT and we will send one to your lab 😎 #phdchat #antibodies
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Very much looking forward to sharing our data at the UVM Microbiology and Molecular Genetics seminar series on Wednesday #uvm #mmg #vermont #vzv #glycoproteins #structure #drslo
instagram.com
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Yes folks! The moment we’ve all been waiting for: Sean McCauley’s thesis project is now live to the world. Congratulations to Sean and his whole #DendriticCell clan @UMassMedical @UMass @GSBS_UMassMed @UMassMedRTI
#HIV
https://t.co/kWPcJ47ukO
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