SRV
@srv_adhikari
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Intersted in Amyloids PhD @ TIFR-Hyderabad; Msc @ Presidency University Bsc @ St.Pauls College-Kolkata, Biophysicist
Joined December 2015
A nice example of secondary nucleation(Abeta42) is presented in Supplementary Movie S2 Full article: https://t.co/vAtVjPUI0T
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Amyloid precursor protein and C99 are subunits in human microglial Hv1 channels that enhance current and inflammatory mediator release | PNAS
pnas.org
In Alzheimer’s disease (AD), hyperactivated microglia produce inflammatory mediators that contribute to neuroinflammation and neuronal damage. Amyl...
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Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency
nature.com
Nature Communications - Tau misfolds in Alzheimer’s disease, but how the link between tau filament structure and pathogenicity is unclear. This study shows that both filament core structure...
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Your cells (and not just the ones in your brain) remember. Fat cells retain an “obesogenic memory” after weight loss: an energetic imprint that primes them to store again. Viewed through the Energy Resistance Principle (ERP), this is a regulatory strategy for energy efficiency.
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A proud moment for IISER Mohali. A hard work well paid for my dear colleagues, Ruchita and Rhitoban, with this wonderful discovery on How termites save their fungal crop from weed invasion. @IiserMohali | Science
science.org
The symbiotic agriculture of fungus-farming termites can collapse if they fail to prevent invading weeds. Previous studies suggest a role for symbiotic fungistatic microbes in bringing about weed...
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FROM CELL DEATH TO REGENERATION: What if dying cells -come back to life? Now online @embojournal I https://t.co/eOKTg6qVnk , we aim to answer this question. Here is the journey. If you🩷science, please dont 🛑till the end of 🧵, I promise you will not regret. 1/n
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This 1998 paper is, without question, one of the most beautiful in the history of biology. It answers two questions: First, how does a potassium channel let in K+ ions while excluding Na+ ions? And second, how does it funnel 100 million of those ions through each second? These
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Fresh off the press! @SimranRawal2 (@tamal_das's lab @TIFRH_buzz) & colleagues find out how organelles inside epithelial cells (lining a wound) reorganise themselves & opt for specific known migratory modes in response to different curvatures of wounds. https://t.co/NzoIPyl0EO
nature.com
Nature Cell Biology - Rawal et al. combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that...
(1/n) Excited to share that my PhD work @tamal_das Lab is now published in @NatureCellBio! How do epithelial cells around a gap sense edge-curvature? We find that the ER acts as a central mechanotransducer, sensing the curvature & guiding cell migration. https://t.co/eTXTBL0LRr
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Excited to share our work just published in @angew_chem Happy to be part of this research👩🔬 We demonstrate the the impact of counterion choice on the aggregation and resulting different emissive state of organic salts! @ChemistryatYork @mcgonigalgroup
https://t.co/Sq8XGo4anx
onlinelibrary.wiley.com
The choice of anion selectively directs the solution-state aggregation of a cationic luminophore, dictating its photoluminescence. Some anions cause emission from a monomeric state, some induce...
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'Never rely on an authority in science. Even the greatest genius can be wrong — whether he has one or two Nobel prizes, or none.' -Erwin Schrödinger
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...and big thanks to @janetiwasa for making this amazing video to illustrate the strand-sliding mechanism!
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Grateful to @biopatrika for the opportunity to discuss our recent findings on ApoE’s isoform-specific effects on Aβ42 aggregation. A pleasure to reflect on the science and story behind the work! article 👉 https://t.co/vAtVjPUI0T
#Alzheimers #Neurodegeneration #Aβ42 #ApoE
nature.com
Communications Chemistry - ApoE-ε4 is the strongest genetic risk factor for late-onset Alzheimer’s disease, linked to increased amyloid-β deposition, however, the molecular...
#authorinterview Sourav Dasadhikari @srv_adhikari from Prof. Kanchan Garai @kanchangarai @TIFRScience talks about his work on "ApoE’s Isoform-Specific Impact on Alzheimer’s Amyloid Growth" https://t.co/OR81dO2GTy via @biopatrika
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A nice example of secondary nucleation(Abeta42) is presented in Supplementary Movie S2 Full article: https://t.co/vAtVjPUI0T
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A nice example of secondary nucleation(Abeta42) is presented in Supplementary Movie S2 https://t.co/vAtVjPUI0T
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PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry | Science Translational Medicine
science.org
Intrathecally dosed antisense oligonucleotide distribution can be imaged in rat and nonhuman primate brains using a PET tracer and click chemistry.
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