Sara Hakim
@sarainthelab
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Interested in neuroimmune interactions, pain, and diabetic neuropathy | @Harvard Ph.D. @UCSanDiego B.S. | 🇪🇬🇺🇸🌍
San Diego, CA
Joined January 2019
My PhD work is finally out in @Nature this week! Again, really grateful for all the support I received from mentors and labmates to get this over the finish line. The revision process has uncovered a few more insights that I think are worth pointing out. https://t.co/L4umgo4WC6
nature.com
Nature - A study in a mouse model of obesity and prediabetes demonstrates that recruitment of macrophages to nerves has a protective role in diet-induced peripheral neuropathy.
Excited to share this pre-print from my thesis work. I spent the past few years developing a model of diabetic neuropathy and unexpectedly found that macrophages infiltrate the nerves of diabetic mice and their recruitment is neuroprotective!!
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Read this #EditorsPick from #PapersoftheWeek from @sarainthelab et al. and @Nature showing evidence that recruitment of macrophages into peripheral nerves delayed terminal sensory axon degeneration in a mouse model of diabetic peripheral neuropathy https://t.co/5iMcFywZSn
#PRF
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Macrophages protect against sensory axon loss in peripheral neuropathy @Nature @sarainthelab
https://t.co/HSOMdgBaDx
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So very proud of my ex-lab mate and forever friend, @sarainthelab! Her PhD paper is an extraordinary body of rigorous research which I believe will shape the field of peripheral neuropathy for years to come! https://t.co/MxC01u7e8R
nature.com
Nature - A study in a mouse model of obesity and prediabetes demonstrates that recruitment of macrophages to nerves has a protective role in diet-induced peripheral neuropathy.
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Nature research paper: Macrophages protect against sensory axon loss in peripheral neuropathy https://t.co/Qj4Dh6cDQO
nature.com
Nature - A study in a mouse model of obesity and prediabetes demonstrates that recruitment of macrophages to nerves has a protective role in diet-induced peripheral neuropathy.
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Finally, we looked at both skin and DRGs of mice fed HFHFD and found no overt recruitment of macrophages suggesting this is likely a response to something happening in the peripheral nerves (again, potentially accumulation of AGEs or SFAs)
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We find that mice lacking Galectin-3 have a similar phenotype to mice lacking macrophage recruitment and think that Galectin-3 could be contributing to the neuroprotective effect exerted by CCR2+macs.. potentially helping clear AGEs or excess Fatty Acids? TBD
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The neuroprotective effect occurs early in the disease, and eventually we find that WT mice catch up to CCR2KO. This suggests that, at first, there are endogenous mechanisms to delay DPN but eventually the pathology takes over. Could we promote those mechanisms to delay onset?
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Featured as an #EditorsPick, at a look at this #PapersoftheWeek find from @sarainthelab and @NatImmunol reviewing the various immune drivers, like cytokines and endogenous opioids, impacting pain resolution and protection https://t.co/eF9xxaTKpq
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Featured as an #EditorsPick, at a look at this #PapersoftheWeek find from @sarainthelab and @NatImmunol reviewing the various immune drivers, like cytokines and endogenous opioids, impacting pain resolution and protection https://t.co/hqRfspthE1
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Beautiful paper by @sarainthelab @Aakanksha__Jain & Clifford J Woolf @BostonChildrens: Immune drivers of pain resolution and protection https://t.co/ayBTl3JynR
nature.com
Nature Immunology - Woolf and colleagues review the current evidence that immune cells could promote pain resolution and prevention through direct effects on sensory neurons and through maintaining...
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Our latest paper details part of our unbiased, high-throughput screening efforts to uncover neuroprotective compounds against chemotherapy-induced degeneration on motor and sensory neurons. 4/1902 compounds worked across both neuronal subtypes. @PhRMA
https://t.co/sPFyi47J81
link.springer.com
Cellular and Molecular Life Sciences - Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect of cancer chemotherapy that can often limit treatment options for cancer patients...
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Guess who made it to the cover of @NatImmunol 🙋🏽♀️✨🥺
Check out our recent work @NatImmunol highlighting how every pain condition is different, and immune cells might hold the key to these differences. As a cherry on top, our DRG image was chosen as the cover art 😃 P.C. @sarainthelab
https://t.co/Vx2YsbsvjX
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So happy to have contributed to this resource and look forward to sharing future work from @Aakanksha__Jain 🤩🥳
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This resource provides mechanistic insights on inflammatory pain and a hypothesis generation goldmine for the field! Not only that, but using this dataset, she identified an endogenous ligand - Tsp1 - that can counteract PGE2 induced sensitization in sensory neurons.
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In this comprehensive resource, out today in @NatImmunol , @Aakanksha__Jain mapped all putative interactions between skin immune cells and nociceptors in 3 different models during peak pain hypersensitivity and the pain resolution phase!
nature.com
Nature Immunology - Woolf and colleagues use single-cell transcriptomics to determine the gene signature of infiltrating immune cells and potential cell–cell interactions between receptors,...
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Check out our latest paper describing the neuro-immune signatures in distinct pain states. I’m very proud to have had the opportunity to contribute to this outstanding research and an invaluable resource for the pain community! https://t.co/uk96WmQ4eF
nature.com
Nature Immunology - Woolf and colleagues use single-cell transcriptomics to determine the gene signature of infiltrating immune cells and potential cell–cell interactions between receptors,...
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Finally did the thing and got that PhD 🥺🥳 🙏🏽 So grateful for my PI, amazing support system in lab, and my family!!! 💗
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Immune drivers of physiological and pathological pain. A new Perspective from Aakanksha Jain (@Aakanksha__Jain), Sara Hakim (@sarainthelab), and Clifford J. Woolf @BostonChildrens: https://t.co/VkXhqkDxTA
#InnateImmunity #inflammation #Neuroscience #Neuroinflammation
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We are delighted to share our latest study published in science translational medicine! Nociceptor spontaneous activity is responsible for fragmenting non–rapid eye movement sleep in mouse models of neuropathic pain | Science Translational Medicine
science.org
Peripheral nerve injury fragments sleep by brief arousals in mouse models.
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