Samir Abu Rumeileh
@s_rumeileh
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MD Consultant Neurologist (Oberarzt), Neurocritical Care Specialist, Researcher on #biomarkers @unimedizinhalle
Lipsia, Germania
Joined August 2020
RT @mattfos89: 👇 Read the full study in Journal of Neurology, Neurosurgery & Psychiatry:. 🔗 Many thanks to Profess….
jnnp.bmj.com
Background Oral anticoagulation (OAC) effectively reduces stroke risk in patients with atrial fibrillation (AF), but its use after intracranial haemorrhage (ICH) remains controversial due to bleeding...
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RT @mattfos89: These results highlight the need for individualized clinical decisions, better risk stratification tools, and (most importan….
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RT @mattfos89: Reduced risk of ischemic stroke (RR 0.23).🔴 Increased risk of recurrent ICH (RR 3.60).⚖️ No clear net clinical benefit (RR 0….
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RT @mattfos89: 🔍 We conducted a systematic review and meta-analysis of randomized controlled trials (including the recently published PREST….
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RT @mattfos89: 🧠💥 Oral anticoagulation after intracranial hemorrhage: risk or relief?. 💊🩸 Patients with atrial fibrillation (AF) face a tou….
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RT @lorbarba: Excited to see our latest work on serum synaptim markers out in @JNNP_BMJ !.Nice collaboration of German, Italian and Spanish….
jnnp.bmj.com
Background Beta-synuclein is an emerging blood biomarker for detecting synaptic damage in Alzheimer’s disease (AD) but its role in early AD as well as in other dementias is unclear. Methods We...
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RT @NicholasAshton: Immunoassay choice for #pTau217 is important! . In this study, we show that LMW #pTau217 is more specific to Alzheime….
alz-journals.onlinelibrary.wiley.com
INTRODUCTION We evaluated differences in p-tau levels between Alzheimer's disease (AD), a condition with brain-specific changes in p-tau, and amyotrophic lateral sclerosis (ALS), a condition associ...
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RT @LabWaggoner: Transplanting dopamine-releasing neurons into the brain is a promising regenerative therapy for Parkinson’s disease shown….
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RT @NEJM: In patients with posterior circulation stroke for whom thrombectomy was not planned, alteplase administered 4.5 to 24 hours after….
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RT @alzforum: Among cognitively healthy people who carried a familial #alzheimersdisease mutation, eight years of gantenerumab halved the o….
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RT @alzforum: P-tau isoforms used as AD biomarkers could also come from damaged muscles in ALS.
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RT @aerztezeitung: Auch bei Menschen mit Amyotropher Lateralsklerose (#ALS) sind die p-Tau-Proteine im Blut offenbar erhöht. Ist ein effekt….
aerztezeitung.de
Auch bei Menschen mit Amyotropher Lateralsklerose (ALS) sind die p-Tau-Proteine im Blut offenbar erhöht. Ist ein effektives Alzheimer-Screening mittels p-Tau so überhaupt möglich?
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Check out our new study!.☑️p-tau 181 and 217 in blood are not as specific for AD as previously thought,.☑️they are also elevated in the blood of patients with ALS,.☑️IHC and MS analyses disclosed both p-tau species in muscle biopsies from ALS cases.
nature.com
Nature Communications - Blood phosphorylated (p)-tau 181 and p-tau 217 have been proposed as accurate biomarkers of Alzheimer’s disease pathology. Here, the authors find p-tau 181 and 217 are...
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RT @mattfos89: Really interesting systematic review on the role of emerging blood biomarkers in the field of epilepsy ‼️Thanks to Annie, Pr….
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Great collaboration between 🇩🇪 and 🇮🇹.
Very pleased to see our article out! We explored for the first time CSF synaptic biomarkers (SNAP-25, ng, beta-synuclein) in MS and found that reduced biomarker levels are associated with brain atrophy at MRI and cognitive impairment 🧠. @s_rumeileh.
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RT @AshuPJadhav: Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-….
thelancet.com
Early DOAC initiation within 4 days after ischaemic stroke associated with atrial fibrillation was non-inferior to delayed initiation for the composite outcome of ischaemic stroke, intracranial...
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RT @AshuPJadhav: Dual Antiplatelet Versus Alteplase for Early Neurologic Deterioration in Minor Stroke With Versus Without Large Vessel Occ….
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RT @JAMANeuro: Is left atrial appendage occlusion a valuable treatment option for patients with atrial fibrillation and #breakthroughstroke….
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RT @BroodingAnanas: “My name is Mike, this is Emily, and in the role of Chester Bennington this afternoon is each of you. Are you ready to….
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Finally out our Paper in Alzheimer’s & Dementia! .✔️We investigated the contribution of αSyn pathology on FDG PET pattern in aMCI subjects. ✔️αSyn+ aMCI showed a marked brain hypometabolism in AD and DLB typical regions. @unimedizinhalle @alzassociation .
alz-journals.onlinelibrary.wiley.com
INTRODUCTION The in vivo detection of mixed Alzheimer's disease (AD) and α-synuclein (αSyn) pathology is important for clinical management and prognostic stratification. We investigated the contrib...
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