Lorenzo Barba
@lorbarba
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MD, Neurology, University Hospital Halle (Saale) 🇮🇹🇩🇪 currently working on fluid biomarkers in neurological diseases 🩸👨🏻⚕️🧠
Joined June 2022
Excited to see our latest work on serum synaptim markers out in @JNNP_BMJ !.Nice collaboration of German, Italian and Spanish groups 🧠. @s_rumeileh.
jnnp.bmj.com
Background Beta-synuclein is an emerging blood biomarker for detecting synaptic damage in Alzheimer’s disease (AD) but its role in early AD as well as in other dementias is unclear. Methods We...
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RT @s_rumeileh: Check out our new study!.☑️p-tau 181 and 217 in blood are not as specific for AD as previously thought,.☑️they are also ele….
nature.com
Nature Communications - Blood phosphorylated (p)-tau 181 and p-tau 217 have been proposed as accurate biomarkers of Alzheimer’s disease pathology. Here, the authors find p-tau 181 and 217 are...
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Very pleased to see our article out! We explored for the first time CSF synaptic biomarkers (SNAP-25, ng, beta-synuclein) in MS and found that reduced biomarker levels are associated with brain atrophy at MRI and cognitive impairment 🧠. @s_rumeileh.
link.springer.com
Journal of Neurology - People with multiple sclerosis (PwMS) experience various degrees of cognitive impairment (CI). Synaptic dysfunction may contribute to CI in PwMS but cerebrospinal fluid (CSF)...
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RT @CambridgeFTD: Fantastic morning at the #DGN Kongress 2024 Berlin, discussing #SynapticHealth and synaptic biomarkers in blood, CSF, PET….
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RT @NSAvramiotis: 🚨Just published in @ESOstroke: Antithrombotic drugs for carotid artery dissection: Updated systematic review🚨. Weak evide….
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RT @PittStroke: Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label t….
thelancet.com
Tenecteplase 0·25 mg/kg was non-inferior to 0·9 mg/kg alteplase within 4·5 h of symptom onset in acute ischaemic stroke. Easier administration of tenecteplase, especially in the context of interhos...
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RT @MicheleRomoli: When small vessel disease #SVD is mixed with #CAA signs, amyloid PET may help identify people at higher risk of cerebral….
neurology.org
ObjectivesCerebral amyloid angiopathy (CAA)-related features on neuroimaging often coexist with signs of arteriolosclerosis-small vessel disease on neuroimaging in people with intracranial hemorrhage...
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RT @JAMANeuro: Is left atrial appendage occlusion a valuable treatment option for patients with atrial fibrillation and #breakthroughstroke….
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RT @Brain1878: Barba et al. review the co-occurrence of Alzheimer's disease and Lewy body disease pathologies, and consider the diagnostic….
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RT @Brain1878: Barba et al. review the co-occurrence of Alzheimer's disease and Lewy body disease pathologies, and consider the diagnostic….
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Extraordinarily excited for our work to be published in @Brain1878 today!. We extensively discuss the clinical and diagnostic implications of #Alzheimer’s disease copathology in Lewy body disease 🧠. @s_rumeileh.@fedemassa88.@mattfos89.@unimedizinhalle.
academic.oup.com
Alzheimer’s disease pathology is commonly found in patients with Lewy body disease and significantly influences the clinical course. Barba et al. review th
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RT @JAHA_AHA: Curious about the feasibility of mechanical thrombectomy after ischemic stroke in the context of cardiac diseases? #AHAJourna….
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Excited for our review on MT in AIS due to cardiological disorders 🧠🫀.A great effort from a great team!. @luciodanna2 .@s_rumeileh .@mattfos89 .@MicheleRomoli.
Finally Out our review exploring for the first time the safety and efficacy Mechanical Thrombectomy in Acute Ischemic Stroke Attributable to Cardiological Diseases | Journal of the American Heart Association @Simona_Sacco_ @mattfos89 @ESOstroke.
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Happy to share our last publication on two new CSF markers of neurosecretory pathways impairment (VGF and neuroserpin) 💧 those biomarkers were associated with AD pathology and cognitive impairment in AD and LBD 🔬🧠. @s_rumeileh.
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Only 12 cases in literature of PRES associated with administration of antibiotics. We reviewed these cases to raise attention on this not negligible neurological syndrome 🧠🦠💊. @s_rumeileh.@mattfos89.@luciodanna2.
link.springer.com
Neurological Sciences - Posterior reversible encephalopathy syndrome (PRES) is an acute neurological condition associated with different etiologies, including antibiotic therapy. To date, most data...
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RT @ChaturvediNeuro: ENRICH trial in @NEJM shows improved outcomes for lobar ICH treated with minimally invasive surgery. Surgery not effec….
nejm.org
Trials of surgical evacuation of supratentorial intracerebral hemorrhages have generally shown no functional benefit. Whether early minimally invasive surgical removal would result in better outcom...
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Honored to share this excellent meta-analysis out on JNNP! All levels (even low levels) of leisure-time physical activity are beneficial for stroke prevention 🏃🏻♂️🧠.@RaffaeleOrnello.@s_rumeileh.@mattfos89.@fededs00.@MicheleRomoli.@luciodanna2.@Simona_Sacco_.
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