Brain and Sleep Research Laboratory
@bsrlaboratory
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The Brain and Sleep Research Laboratory is a joint effort of Luisa de Vivo and Michele Bellesi to investigate the neurobiology of sleep and wakefulness
Camerino, Italy
Joined January 2019
Simultaneous EEG-PET-MRI identifies temporally coupled and spatially structured brain dynamics across wakefulness and NREM sleep https://t.co/iMmGlQSP64
nature.com
Nature Communications - Using simultaneous EEG-PET-MRI, this study reveals tightly coupled physiological dynamics during the descent from wakefulness into NREM sleep and identifies network-specific...
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🚨 New paper alert! 🚨(1/6) Excited to share our work, out now in Science Advances We show that a rapid norepinephrine surge along a brainstem pathway (LC→PRN) is a key driver of sound-evoked awakenings https://t.co/O9q4qWOmzR
science.org
The locus coeruleus has a specialized pathway to the brainstem that controls sound-evoked awakening from sleep.
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Can you rejuvenate an old brain by giving it young immune cells? 🧠My lab @calico put it to the test. In our new study, we replaced the brain's immune cells in old mice with young ones. The result? The old brain environment forced the young cells to age RAPIDLY. A 🧵👇
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Enhancement of Sleep Slow Wave Activity using Transcranial Electrical Stimulation with Temporal Interference
medrxiv.org
Slow waves mediate restorative functions of non-rapid eye movement (NREM) sleep. To enhance slow wave activity (SWA, 0.5-4 Hz) non-invasively, we employed a novel neuromodulatory tool, Transcranial...
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Mitochondrial origins of the pressure to sleep https://t.co/qQf9jYP14V
nature.com
Nature - Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
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To all rodent sleep researchers 🚨! Tired of non reproducibility in sleep scoring? The @ESRS_Sleep launches a call to develop a manual for the recording and analysis of sleep in laboratory rodents. Apply here ( https://t.co/saThoc6MmH) if you are interested!!
esrs.eu
Applications closed
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㊗️ our paper was finally accepted by Nature Communications! Data & paper are already accessible from here: DREAM: A Dream EEG and Mentation database https://t.co/pSqii499T6 Thanks all coauthors for contributing the data! It was a really long journey to arrive here...
osf.io
Magneto/electroencephalography (M/EEG) studies of dreaming are an essential paradigm in the‬ †investigation of neurocognitive processes of human consciousness during sleep, but they are limited‬ â€...
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Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux
nature.com
Nature Communications - The authors find cholinergic neurons regulate glymphatic waste clearance via neurovascular mechanisms, with their loss impairing this process. This finding suggests targets...
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Neuroendocrine circuit for sleep-dependent growth hormone release: Cell
cell.com
The increase in growth hormone release during sleep is driven by sleep-wake-dependent activity of stimulatory GHRH neurons and inhibitory SST neurons in the hypothalamus. The released growth hormone...
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A time window for memory consolidation during NREM sleep revealed by cAMP oscillation: Neuron
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Increased CSF drainage by non-invasive manipulation of cervical lymphatics https://t.co/iDqGQpjoZE
nature.com
Nature - The outflow pathway of cerebrospinal fluid into lymph nodes in the neck and how non-invasive mechanical stimulation can enhance drainage and restore impaired outflow in aged mice are...
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Astrocytes.. we haven't been paying enough attention: https://t.co/GsY4NRiMPF
science.org
Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-le...
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Global coordination of brain activity by the breathing cycle https://t.co/MyZEZAiUeQ
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How much energy does it cost to fuel cognition and everything else the brain does? Fueling the brain costs 20-25% of the whole body's energy budget, even if the brain is only around 2% of body weight Thinking hard doesn't change energy demand much https://t.co/pJ4nnejbHE
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Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep https://t.co/zsDckUmePr
nature.com
Nature Communications - Neural mechanisms underlying memory acquisition and encoding are not fully understood. Here authors show that during sleep, besides the replay of past memory, coactivity of...
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Spatiotemporal dynamics of cortical slow waves in the human cortex (in vitro) https://t.co/Kx3lH4ctTM
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Sleep homeostasis in lizards and the role of the cortex | PNAS
pnas.org
Slow-wave sleep (SWS) and rapid eye movement sleep are the two primary components of electrophysiological sleep (e-sleep) in mammals and birds. Slo...
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A time window for memory consolidation during NREM sleep revealed by cAMP oscillation: Neuron
cell.com
Sleep is crucial for memory formation. Deng et al. find that cAMP levels in mice oscillate with a 1-min cycle during slow-wave sleep, and hippocampal activity at the peak of these oscillations is...
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Plasticity induction in the ventromedial prefrontal cortex during REM sleep improves fear extinction memory consolidation https://t.co/vX8AzEdMO9
#biorxiv_neursci
biorxiv.org
Anxiety disorders (ADs) are among the most prevalent mental health conditions, yet first-line treatments often yield only moderate effectiveness. The fear conditioning paradigm is commonly used to...
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