RT @HaydnKissick: Check out our latest paper in @ImmunityCP, “Identification of indirect CD4+ T cell epitopes associated with transplant re….

RT @ICGEBNewDelhi: The inaugural meeting of the program on Human Immunology of Cervical Cancers was held today at @ICGEBNewDelhi . The eve….

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RT @ACIR_org: McManus and Valanparambil et al. showed that nearly identical stem-like (PD-1+TCF-1+TOX+) CD8+ T cells emerged as early as da….

RT @ImmunoPodcast: Drs. Daniel McManus (@dmcmanus123), Rajesh Valanparambil, and a team in the @rafiahmed_lab studied how precursors of exh….

RT @HaydnKissick: Thanks to @Immunity for publishing our work looking at the CD4 T cell response against transplanted organs. Will have a t….

RT @ImmunityCP: Online now: Identification of indirect CD4+ T cell epitopes associated with transplant rejection provides a target for don….

RT @Nature: Nature research paper: Differentiation fate of a stem-like CD4 T cell controls immunity to cancer

Check out the new work by the excellent PhD student @Maria_Carden1 who has worked with our lab for many years. Even managed to get some LCMV into her nice paper on cancer!.

RT @IanParish_AU: We’ve known about tolerant CD8+ T cells for >25 yrs – but what are these cells?! Prematurely exhausted, stalled effectors….

RT @HaydnKissick: Thanks for having me ICGEB !- It was wonderful to meet all your faculty and amazing students. I hope I'm back again very….

RT @ICGEBNewDelhi: A meeting was held today between the officials of @ICGEBNewDelhi & @EmoryVaccineCtr, Emory University at ICGEB New Delhi….

RT @ICGEB: This week @NatureMedicine Dr. Anmol Chandele @ICGEBNewDelhi published an analysis of severe #dengue cases in a cohort of childre….

RT @kathleenabadie: It’s a big day for us today as we share the @Kueh_Lab’s latest work, just out in @ImmunityCP . We set out to understand….

RT @Kueh_Lab: So proud to share our work on memory T cell generation, now out in @ImmunityCP! This huge paper is the heroic work of @kath….

Our findings question the currently widely held belief that severe dengue is associated predominantly with secondary infections and emphasizes the importance of developing vaccines or treatments to protect dengue-naive populations.

Consistent with the classification based on binding antibody data, dengue neutralizing antibody titers were also significantly lower in primary infections compared to secondary infections (P ≤ 0.0001).

During these studies, seven fatalities were reported. Five of the seven fatalities were associated with primary dengue infections and two with secondary infections.

46.7% of severe disease cases were primary dengue infections in children aged between 1 and 3 years; 50.3% of severe dengue cases were primary dengue infections among children aged 4–16. Thus, severe dengue was seen during primary dengue infections irrespective of age

As a more stringent criteria for defining a primary infection, we looked at dengue cases analyzed at early time points after the onset of symptoms (on or before day 4) and were IgG−. These IgG− patients also showed similar severe disease frequency during this primary infection.

Figure 1a: We classified primary and secondary infections based on IgM:IgG ratios using a dengue-specific ELISA according to the World Health Organization guidelines. These data show disease severity was not preferentially associated with secondary dengue infections