Ramon Bataller
@rabataller
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Chair, Liver Unit, Hospital Clinic, Barcelona.
Barcelona, Spain
Joined December 2010
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Pinned Tweet
Happy to share with you our review on ALCOHOL-ASSOCIATED HEPATITIS, published today in the
@NEJM
.
We dedicate it to all our patients. We will continue to work together to beat it.
@Dr_Vijay_Shah
@juanpabloarab
#LiverTwitter
#MedTwitter
70
467
2K
My dad, Ramon Bataller Sr., died today. He was a hepatologist who conveyed to me the love for liver patients, especially those with alcohol problems.
I want to thank a generation of hepatologists who, like my father, inspired us.
#LiverMtg21
#LiverTwitter
@AASLDtweets
115
17
564
Today I start as a Chair of the Liver Unit in the Hospital Clinic, Barcelona.
It is an honor to be back in such a great hospital. I am excited to serve the patients and a wonderful group of hepatologists.
@hospitalclinic
@liverunitclinic
@BCLC_group
@LiverIcu
#LiverTwitter
85
30
547
The most dangerous phase in a doctor career is when you start thinking your are an expert but actually you DON’T KNOW WHAT YOU DON’T KNOW.
It happened to me what I was in my 30s.
#livertwitter
#MedTwitter
16
137
451
Mentoring advice: be ambitious, but never consider other colleagues working in your field as rivals. Instead, cooperate to beat the disease your are working on.
Federer & Nadal showed us the path. They are my role models.
#ThankYouRoger
#livertwitter
7
83
419
60 years ago today, Dr. Thomas Starzl and his team did the 1st liver transplant.
His pioneer work paved way for modern organ transplant, saving countless lives.
#donatelife
#LiverTwitter
#MedTwitter
@UPMC
1
98
404
Today in my clinic I realized how difficult is to treat SYMPTOMS in cirrhosis:
🔸 Pain
🔸 Itching
🔸 Muscle cramps
🔸 Appetite and sadness
This REVIEW helped me to find some practical solutions.
#livertwitter
#medtwitter
5
109
373
Today is my last day working as a doctor in the USA.
It was an honor to work at
@UNCGastro
and
@PittGILiverNutr
My main reward has been serving American patients, especially those with alcohol problems.
Thanks to all and see you in Barcelona !
#livertwitter
@AASLDtweets
35
16
360
How to manage PORTAL VEIN THROMBOSIS in people with cirrhosis and non-cirrhotics ?
🔸What pro-thrombotic work up ?
🔸When and what type of anticoagulant ?
🔸For how long ?
This excellent review in
@JHEP_Reports
tell you all.
#LiverTwitter
#medtwitter
1
105
268
A new paper and a tribute. We show in a global study that MELD best predicts 28d mortality in Alc Hep and that Maddrey's DF should not be used. I presented this in Johns Hopkins, and Dr. Maddrey congratulated me. A true gentleman.
#livertwitter
#medtwitter
8
67
258
A must-read review on ACUTE KIDNEY INJURY in cirrhosis in
@NEJM
by the great
@ggarciatsao
.
AKI commonly complicates cirrhosis. The management and emerging therapies are deeply discussed.
#livertwitter
#MedTwitter
1
106
247
This is my minimalist view of the new
#NAFLDnomenclature
:
🔸Mostly metabolic: MASLD
🔸Dual metabolic & alcohol: MetALD
🔸Mostly alcohol: ALD
#EASLCongress
@EASLedu
@EASLnews
@AASLDtweets
@alehlatam
@marurinella
@GCastro_NarroMD
@norahterrault
8
103
245
How to treat AUTOIMMUNE HEPATITIS ?
Prof. Manns proposes this algorithm in:
- AIH without cirrhosis
- AIH with cirrhosis
- Acute severe AIH
#livertwitter
#medtwittwer
4
75
245
Great results from the first clinical trial testing NALTREXONE vs placebo in alcohol-related cirrhosis, today at
#TLM23
:
🔸Naltrexone is well tolerated
🔸It favors abstinence
🔸It reduces by 50% new onset decompensation
@AASLDtweets
#livertwitter
#MedTwitter
@ILBS_India
8
82
235
What is new in HEPATORENAL SYNDROME ?
This great review provides an update on:
🔸Role of systemic inflammation
🔸Pharmacological therapy
🔸Indications of RRT and liver-kidney transplant
@AmerGastroAssn
#livertwitter
#MedTwitter
6
92
196
Finally, a study assessing NALTREXONE for alcohol use disorder in liver patients !
It seems safe in compensated cirrhosis. I am increasingly using it, yet RCTs are warranted.
#Livertwitter
@ebtapper
@norahterrault
3
65
195
This paper will be transformational: 25% of patients with presumed NAFLD were drinking ALCOHOL excessively. Some patients admitted it, but many others underreported it.
“THE DIAGNOSIS OF NAFLD SHOULD REQUIRE NEGATIVE ALCOHOL METABOLITES”.
#LiverTwitter
11
66
194
How to manage people with NAFLD ?
🔸How can we identify HIGH RISK patients?
🔸What patients should be referred to a hepatologist?
This review summaries the NAFLD management ALGORITHMS proposed by major international societies.
#livertwitter
#medtwitter
4
97
192
Abdominal obesity increases alcohol-related liver toxicity by 4-fold.
I showed this picture to a patient with obesity that asked me if it was OK to drink 2 beers per day.
#livertwitter
#medtwitter
11
61
188
Happy to share the new
@AmCollegeGastro
"Clinical Guideline: Alcohol-Associated Liver Disease":
🔸Increasing in young women
🔸Early detection needed
🔸Criteria for early LT for AH
@AmCollegeGastro
#livertwitter
#MedTwitter
8
68
182
Great review on LIVER TRANSPLANTATION in the
@NEJM
by Lucey, Furuya & Foley:
🔸Indications
🔸Assessment
🔸Current trends & challenges
#livertwitter
#MedTwitter
@AASLDtweets
@EASLedu
5
55
182
The LiverRisk score, a study including 15,000 people, just released in
@TheLancet
:
🔸Based on simple liver function tests.
🔸It predicts liver fibrosis and liver-related outcomes in the general population.
#livertwitter
#medtwitter
:
@Liver_Screen
3
61
176
This study including 27 million people shows increased risk of developing liver disease in people undergoing CHOLECYSTECTOMY.
Strict indications should be imlemented to reduce unnecessary cholecystectomy.
#livertwitter
#medtwitter
7
64
172
Why AST is increased in advanced fibrosis and is included in serum tests (FIB-4, APRI and LiverRisk score) ?
🔸AST is mostly in the mitochondria and is released in advanced disease.
🔸AST is increased by alcohol, a strong fibrogenic factor.
#livertwitter
#medtwitter
@EASLedu
1
47
167
I get many patients in my clinic with HIGH FERRITIN.
If I suspect alcohol, I don’t request HFE genetic tests the first visit. Instead, I assist them to stop drinking and I test FERRITIN again.
In most cases, iron tests normalize after abstinence.
#livertwitter
#medtwittwer
11
25
169
Important study by
@DrLoomba
in
@JHepatology
:
🔸1 out of 7 diabetics have advanced liver fibrosis.
🔸 If they are obese, 1 out of 5.
With these numbers, SCREENING of liver fibrosis should be mandatory in people with type 2 diabetes.
#livertwitter
#MedTwitter
@EASLedu
8
68
165
Good news for MASLD just published in the
@NEJM
!
Resmetirom, a selective agonist of THR-β, reduces fibrosis and steatohepatitis.
Once approved, real world data will be important.
#livertwitter
#MedX
3
45
165
How to select patients with alcohol-associated hepatitis for EARLY liver transplantation ?
I think this practical algorithm is very useful.
@juanpabloarab
@LuisAntonioDiaz
@DrLoomba
@APandT
2
70
163
Why NAFLD favors metabolic and cardiovascular diseases ?
The role of HEPATOKINES may be the answer.
This excellent review in
@Cell_Metabolism
explains it all.
#livertwitter
#MedTwitter
3
55
162
Why fatty liver favors hepatic METASTASES ?
This brilliant study by
@SekiEki
proves that extracellular vesicles in fatty liver promote a metastatic tumor microenvironment.
#livertwitter
#MedTwitter
3
60
157
Today I asked our fellows to write a list with the long-term Side Effects of Omeprazol (in red the most relevant for liver patients).
We came out with this list:
#livertwitter
#MedTwitter
6
60
159
Patients with decompensated alcohol-related cirrhosis that achieve abstinence are able to recompensate and improve their survival.
It’s NEVER TOO LATE to stop drinking !!
#livertwitter
#medrwitter
1
45
157
Differentiating between alcohol withdrawal & encephalopathy is very important in patients with Alc Hep. Don't rely only on ammonia levels.
The TIMING from the last drink and the TYPE of symptoms can help.
#livertwitter
6
61
157
Is safe for a patient with alcoholic liver disease to drink ALCOHOL-FREE BEER ? I don't recommend it:
▪️It still has some alcohol (0.1-0.5%)
▪️Patient keeps doing a bad habit
▪️We showed that it predicts relapse
#livertwitter
#MedTwitter
7
47
156
How to evaluate and refer patients with NAFLD across primary care and GI/Hepatology settings ?
The new
@AASLDtweets
Clinical Guidelines on NAFLD by
@marurinella
@DrLoomba
et al. proposes a practical algorithm.
#LiverTwitter
#medtwitter
3
59
156
This large study on the use of PROTON PUMP INHIBITORS in cirrhosis has important clinical implications:
🔸PPIs can favor infections and decompensation.
🔸They are only beneficial in patients with a previous GI bleed.
#livertwitter
#medtwitter
0
62
150
Novel convincing paper showing that BETA-BLOCKERS prevent liver decompensation.
The great hepatologist-statistician
@JuanAbraldes
led this effort.
#livertwitter
@aeeh
@AASLDtweets
@HEP_Journal
3
51
152
Today, Dr. Miquel Navasa retired from the Hospital Clinic of Barcelona. In my career, I've never met a physician with a better clinical eye. Thanks, Miquel for your service to so many patients and for training many of us. Your greatness will never retire.
@liverunitclinic
6
19
148
Read our review in
@NatRevGastroHep
on the intersection between alcohol and metabolic-associated liver disease.
We need combined lifestyle changes and novel medications.
#livertwitter
#MedTwitter
2
54
150
In current hepatology, with the majority of hospitalized patients with alcohol-related liver disease, I think it would be very useful if liver FELLOWS have a brief rotation in ADDICTION MEDICINE.
#MedTwitter
#livertwitter
@EASLedu
@AASLDtweets
10
24
149
New
@AASLDtweets
Guidelines for NAFLD just released !!
Two of the recommendations:
🔸STATINS should be used to prevent CVD events.
🔸ZERO ALCOHOL if significant fibrosis.
@marurinella
@DrLoomba
#livertwitter
#MedTwitter
2
32
144
They recently asked me: when is TOO LATE to stop alcohol drinking if you have end-stage cirrhosis ?
Well, I’ve had cirrhotic drinkers sent to nursing homes for palliative care that recompensated because they couldn’t drink there.
ANSWER: it’s never too late.
#LiverTwitter
8
29
146
Hepatorenal syndrome:
🔸Why does it happen ?
🔸How to diagnose and grade it ?
🔸How to use terlipressin and when is RRT needed?
This great review in
@AGA_Gastro
tells you all.
#livertwitter
2
49
149
We propose an algorithm to treat alcohol use disorder before and after liver transplantation. More clinical trials are needed in this field.
@juanpabloarab
@Lorenzo__Leggio
@Dr_Vijay_Shah
@manhalizzy
#livertwitter
2
54
143
Do you know which is the most HARMFUL DRUG to the users and the people around them ?
This study in
@TheLancet
showed that the number one is ALCOHOL.
#livertwitter
#MedTwitter
7
66
143
A massive study in >100,000 people in
@LancetGastroHep
shows that almost 3 out 4 people with obesity have FATTY LIVER.
Who are more likely progress to cirrhosis/cancer ?
🔸Unfavorable genetic background
🔸Diabetics
🔸Drinkers & smokers
#livertwitter
#MedTwitter
4
50
142
Did you know that LIVER CANCER is one of the 3 top causes of cancer-related death in 46 countries ?
And its incidence is rapidly growing due to fatty liver disease.
#LiverCancerAwarenessMonth
#livertwitter
@JHepatology
3
74
142
Really proud of
@juanpabloarab
, a rising star in hepatology, who received the AWARD OF BEST YOUNG INVESTIGATOR from
@ucatolica_chile
@FacMedicinaUC
. Mentored by
@Dr_Vijay_Shah
, he has made great contributions in the fields of ALD and NASH.
#livertwitter
@MayoClinicGIHep
25
16
139
In pilot study, we showed that RIFAXIMIN may be beneficial in ALCOHOLIC HEPATITIS:
🔸Less infections and muti-organ failure.
🔸Increased survival.
This promising results need to be confirmed in a RCT.
#livertwitter
#medtwitter
2
38
140
Mentoring advice: mid career physicians and scientists have told me: "Ramon, why I am not invited to conferences or reviews ?" My answer: YOU NEED TO FOCUS. You have to find a topic and stick to it. Do the exercise below. Each dot represents a paper.
#livertwitter
#medtwitter
6
29
137
The LARGEST GENETIC study (>500k people) in liver patients in the
@NEJM
:
🔸Rare germline mutations explain why some people are resistant to develop liver disease.
🔸Mutations in genes regulating steatosis are protective against NASH.
#LiverTwitter
1
55
135
Why does obesity increase all-type cancer ? Does weight loss decrease cancer risk ?
This huge meta-analysis including 24M people reviews the mechanisms and shows that a weight loss of >5 kg reduces overall cancer risk.
#livertwitter
#MedX
2
62
137
When should we give PROPHYLACTIC ANTIBIOTICS in cirrhosis ?
Do we prevent mortality or we promote multi-resistance ?
This practical algorithm in
@HepCommJournal
guides us to follow an evidence-based and common sense approach.
#livertwitter
@ebtapper
2
52
136
The long-awaited trial on AMOXICILLIN-CLAVULANATE prophylaxis in alcohol-related hepatitis finally published in
@JAMA_current
:
🔸Well tolerated.
🔸No survival benefit.
@AASLDtweets
@EASLedu
#livertwitter
#medtwitter
4
70
135
#MentoringAdvice
When I was on call in the past, I asked my fellows: please call me if you have any doubt.
Only
@jturnesv
and
@JuanAbraldes
used to call me, and they are now very successful.
ASKING for HELP is not a sign of weakness, but shows self-confidence.
#livertwitter
9
32
134
How can we predict clinical outcomes in NAFLD?
Do we need biopsy? Are non-invasive tests good enough?
A study in >2,500 biopsy-proven NAFLD in
@LancetGastroHep
shows that non-invasive tests are comparable to liver biopsy.
#livertwitter
#MedTwitter
3
49
133
Why ALT levels are normal/low in alcohol-associated hepatitis ?
🔸AH is NOT a necroinflammatory disease. It is mostly due to de-differentiation of hepatocytes.
🔸ALT is vitamin 6 -dependent and many patients with AH have profound vitamins deficiency.
#livertwitter
#medtwitter
0
27
135
During my 30s and 40s, I mostly needed EXTERNAL validation (publications, positions, compliments..)
In my 50s, I realized that INTERNAL validation is far more rewarding.
I wish I would have known it earlier !
#mentoningadvice
#livertwitter
@EASLedu
7
12
132
Acute-on-chronic liver failure is the most severe consequence of cirrhosis.
What are the most promising THERAPIES ?
This fantastic review by
@RajivJalan1
et al. explains it all.
@SeminLiverDis
@DrPMonga
#livertwitter
1
54
130
What is the BEST DIET for patients with fatty liver ? What is the scientific evidence supporting their health benefits ?
This critical and didactic review explains it all.
#livertwitter
#MedTwitter
@EASLedu
1
51
130
So proud to be part of a great team. The University of Barcelona number 4 in GI and Hepatology in the world !
Top Gastroenterology and Hepatology Schools in the World - US News Education
@hospitalclinic
@UniBarcelona
@liverunitclinic
#livertwitter
6
28
126
Why cirrhotics with infections are prone to bleed ?
Besides increasing portal pressure, this study in
@JHEP_Reports
shows that infections impair PLATELET function.
#LiverTwitter
3
51
126
I saw a patient with metabolic syndrome, a BMI of 38 and 5-6 beer consumption per day.
If his fatty liver disease due to:
🔸NAFLD ?
🔸ALD ?
🔸Dual etiology ?
See my answer in this minimalist graph. The dot represents this patient.
#livertwitter
@AASLDtweets
@EASLedu
15
27
125
Kristen, the amazing addiction counselor that worked with me in Pittsburgh, sent me this cartoon.
So true !!!!
#MedTwitter
#LiverTwitter
6
16
127
I've seen too many brilliant young doctors giving up on their dream to become a PHYSICIAN-SCIENTIST.
It is a critical career path to translate science into medicine.
ACADEMIC CENTERS should support it much more.
@AASLDtweets
#livertwitter
@EASLedu
2
20
126
Remember that the first objective in a patient with decompensated cirrhosis is achieving RECOMPENSATION.
This great article in
@NatRevGastroHep
reviews the mechanisms of recompensation in fatty liver.
@VirginiaHdezGea
@GiadaSebastiani
#livertwitter
2
40
124
Can we identify patients with alcoholic hepatitis that spontaneously recover and will not need an early liver transplant ?
We showed in an international study that TRAJECTORY of BILIRUBIN is the key, regardless of the therapy.
#MedTwitter
#LiverTwitter
4
35
122
What are the most promising new therapies for NASH ? What are their mechanism of action ?
This fantastic review in
@JHepatology
tells you all.
#LiverTwitter
@VladRatziu
2
38
123
This impressive study by Jay Luther
@alcliverdoc
shows that treating ALCOHOL USE DISORDER prevents liver-related decompensation. Drugs that show promise:
🔸Naltrexone
🔸Gabapentin
🔸Topiramate
🔸Baclofen
#livertwitter
7
28
124
So sad about the passing of Stephen Harrison, one of the most influential leaders in hepatology, and a great person.
His legacy, including the first drug for MASLD, his talent and his kind demeanor will remain with us.
#livertwitter
@EASLnews
@AASLDtweets
8
21
123
A must-read review on one of the hottest topics in hepatology: IMMUNOTHERAPY-INDUCED LIVER INJURY.
It includes:
🔸Pathogenesis.
🔸Grading.
🔸Management algorithm.
#livertwitter
#medtwitter
9
42
120
Do patients with Alc Hep have CIRRHOSIS? My answer:
🔸NO CIRRHOSIS (20%): huge liver, rapid recovery.
🔸EARLY CIRRHOSIS (50%): big liver, slower recovery, intermediate prognosis.
🔸ADVANCED CIRRHOSIS (30%): nodular liver in imaging, poor prognosis.
#livertwitter
#medtwitter
2
33
118
The results from the IMPORTAL study by the
@BavenoVII
add a 3rd tenor to treat compensated cirrhosis: ANTICOAGULATION.
These are the 3 TENORS in the current treatment of cirrhosis:
1. Statins
2. Carvedilol
3. Anticoagulants
#medtwitter
#livertwitter
3
47
118
Excellent update on HEPATOPULMONARY SYNDROME in
@JHEP_Reports
:
🔸Reviewed diagnostic criteria
🔸Window for liver transplant
🔸Pathogenesis and promising therapies
@EASLedu
#livertwitter
#MedTwitter
1
37
119
Do you use PROCALCITONIN as a biomarker for infection in cirrhosis? In Alc Hep, we found that 83% of patients with >0.45 ng/mL were infected, as opposed to 29% of patients with <0.45 ng/mL. This could be useful in patients with isolated high white cell count.
#livertwitter
2
37
118
Does sugar or sweetener decrease the beneficial effects of coffee?
This large prospective study just showed that COFFEE DECREASES MORTALITY, but:
🔸Coffee only is the best
🔸Adding sweetener is OK
🔸Adding too much sugar is detrimental
#livertwitter
3
48
115
Is it safe for the liver to drink heavily the WEEKEND and be sober during the rest of the week?
Probably YES. But if you have METABOLIC SYNDROME, definitively NO.
We explain it in this editorial with
@CotsVentura
#livertwitter
3
39
115
A study including >11k patients show that STATINS also decrease mortality in patients with acute-on-chronic liver failure (ACLF).
Is there anything that statins can´t do for liver patients ?
#LiverTwitter
#MedTwitter
@EASLedu
@JHEP_Reports
4
45
115
Mentoring advice: before submitting a paper or a grant, PRINT it, get a pen, go to a quite place and read it carefully.
If you have not found 10 mistakes, read it again.
#livertwitter
4
14
115
Mentoring advice: if you want to influence your workplace and be respected in your field, don’t underestimate the POWER of KINDNESS.
#livertwitter
3
26
113
We just showed that half of doctors don't discuss with their patients with alcoholic cirrhosis the need to get therapy for ALCOHOL USE DISORDER.
I think that this will improve with more studies, training and awareness.
#livertwitter
#MedTwitter
6
39
114
I met a person top in his field that was taking notes during a lecture given by a young colleague.
He tough me that the day we think we know everything, it will be the beginning of our career decline.
#livertwitter
#mentoringadvice
@EASLedu
2
18
114
This is a must-read review on DRUG-INDUCED AUTOIMMUNE-LIKE HEPATITIS.
A unique entity in terms of diagnosis and management. The algorithm is very useful !
#livertwitter
#medtwitter
@EASL
@JHepatology
0
37
113
Save this table: MEDICATIONS for treating alcohol use disorder.
This is shown in a great article by Jessica Mellinger on practical recommendation to treat these patients.
#livertwitter
#MedTwitter
@AmJGastro
@UMich
1
44
113
WOMEN are more vulnerable to the effects of alcohol:
🔸More prone to develop cirrhosis and Alc Hep.
🔸More social STIGMA.
🔸Less access to liver transplantation.
We need to protect them and tackle this problem !
#livertwitter
#medtwitter
8
43
112
"ALCOHOL-INDUCED BOWEL DISEASE", a new concept that recapitulates all the profound changes that alcohol causes in GI tract.
This article nicely reviews its clinical features and pathogenesis.
#livertwitter
#MedTwitter
@eGastro_BMJ
@NIAAAnews
1
38
112
What do acute pancreatitis and alcoholic hepatitis have in common ?
🔸They cause SIRS.
🔸SIRS (leukocytosis, fever, etc) can be STERILE.
Serum PROCALCITONIN (an infection biomarker) can be useful to avoid unnecessary antibiotics.
#livertwitter
4
26
111
My first thought when I first see a person with complicated cirrhosis is: can we RE-COMPENSATE it ?
The best way is to treat the CAUSE such as alcohol.
This article by
@BavenoVII
explains it all.
#livertwitter
#MedTwitter
1
33
112
Compared to ascites, hepatic HYDROTHORAX:
- Poor response to diuretics, >AKI and HipoNa.
- Repeated thoracocentesis is hard: consider TIPS.
-Increased mortality with lower MELD.
This study in
@HEP_Journal
shows its poor prognosis.
#LiverTwitter
1
41
112
Many of the new drugs approved for cholestasis and also soon for NAFLD target BILE ACIDS (FXR agonists, FGF19, etc).
This fantastic review discusses these emerging therapies.
#livertwitter
@NatRevGastroHep
0
30
112
In 2021 we identified a problem: NASH-HCC do not respond to immunotherapy. In 2022, a fascinating study by
@derekamann1
found a solution: blocking neutrophil-derived CXCR2 sensitizes these tumors. Translational science advances medicine!
#livertwitter
1
31
109
This is a must read seminar on HEMOCHROMATOSIS in
@TheLancet
- Why the European ancestry
- Pathogenesis
- Current therapy and drugs in the pipeline
#livertwitter
#MedTwitter
1
35
110
This AASLD meeting has 10 times more content on healthy diet, exercise and alcohol abstinence and the need of better public health policies.
Finally we are tackling the root of the problem: in 2021, most liver diseases can be prevented !!!
#livertwitter
@AASLDtweets
#LiverMtg21
2
28
108
Just a simple ECG can be useful to identify cirrhosis and its severity.
The Mayo Clinic team is leading the field of using ARTIFICIAL INTELLIGENCE in hepatology!
@JosephCAhnMD
@DougSimonetto
@Dr_Vijay_Shah
@MayoClinicGIHep
#LiverTwitter
#MedTwitter
1
40
109
Why a thyroid hormone receptor- agonist has won the race as the 1st drug to treat MASLD ?
This fantastic review on
@Gut_BMJ
explains the reasons.
#MASLD
#livertwitter
#medX
1
45
109
How to treat PRURITUS in patients with cholestasis ?
Sometimes, it is more difficult that treating pain. This great review in
@NatRevGastroHep
details the available therapies and their mechanism of action.
#livertwitter
#medtwitter
1
39
107
In my ALD clinic, I noticed that more than 30% of my patients have >2 components of the metabolic syndrome.
Happy that
@NatRevGastroHep
devotes its cover to our article on this relevant clinical topic.
@EASLedu
#livertwitter
#MedTwitter
0
36
106
These are the 3 hallmark papers of the evolving nomenclature from NASH, MAFLD to the non-stigmatizing MASLD.
Happy to review this roadmap today, and the new concept of MetALD in the great annual
@AEEHLiver
meeting.
#livertwitter
#AEEH2024
2
31
105
🔸Why so many clinical trials are failing in fatty liver disease (NAFLD/MASLD) ?
🔸What are the most promising drugs in the pipeline ?
This great review in
@LancetGastroHep
addresses these questions.
#LiverTwitter
#MedTwitter
2
56
106
Why so many clinical trials in NASH are failing ?
- Placebo arms improve due to weight loss.
- Heterogenous patients.
- Need to better control the effect of underreported ALCOHOL: biomarkers needed!
#livertwitter
#MedTwitter
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