Great to see our PANDORA-seq .& .Perspective on the exploration of small RNA universe both highlighted @NaturePortfolio among the collection of key methods & resources of the noncoding RNA field👇.

RT @DiStefano_Lab: New preprint from the lab! With @Brumbaugh_JB, we show that P-bodies sequester developmentally relevant RNAs to influenc….

Very glad to see our Sequential Activation Hypothesis highlighted on the cover @TrendsBiochem, linking small RNA-TLR interactions to autoimmune disease mechanisms.

We put together a step-by-step protocols for PANDORA-seq, now available in @NatureProtocols, including the sample preparation for sperm, sperm heads; and the analyzing software SPORTS optimized for various types of small RNAs including tsRNAs, rsRNAs, and miRNAs.

Proud of the team @happy_jjcc @XudongZhang90 @cai000chen @tongzhoulab for thinking fearlessly to put the ideas together!.

This idea is driven by advanced sncRNA sequencing (e.g. PANDORA-seq), uncovering an expanding universe of tsRNA/rsRNA/ysRNA & more These sncRNAs go beyond RNAi, adopting aptamer-like roles by binding TLR7/8 to shape immune responses.

TLR7/8 aren’t just triggered by viral RNAs, they can be potentially activated by a range of RNA resources: cell stress/death, RNA therapies, microbiome, and even dietary RNAs. Uncovering these diverse triggers may pave new paths for preventing/treating autoimmune diseases.

How can abnormal small RNA biogenesis spark autoimmune disease? Our opinion @TrendsBiochem discuss a novel two-stage activation hypothesis that may explain why autoimmunity hits women harder, via small RNA-TLR7/8 interactions & augmented by autoantibodies.

Much enjoyed the #tRNA2024 conference at Kanazawa, Japan. Exciting science & great people!.Love the excursion to the historic village Shirakawa-go 😀

RT @NobelPrize: BREAKING NEWS.The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the disc….

Very much honored to deliver a Keynote at EMGS 2024 and to reconnect with old friends while making new ones. May the reflections on the past journey illuminate the road ahead. .

Congratulations Changcheng! Great to see increasing evidence of sperm-mediated epigenetic inheritance and the involvement of small RNAs. Thanks for including me in this exciting project!.

RT @qichen_lab: This mass spec-based RNA-seq can serve as a powerful tool to decode the RNome, complementary to Nanopore sequencing, with a….

RT @sz2110: Our JACS paper on direct RNA sequencing, revealing the true RNA sequence (RNome) using mass spectrometry, was published today (….

This mass spec-based RNA-seq can serve as a powerful tool to decode the RNome, complementary to Nanopore sequencing, with advantage in De Novo sequencing of highly modified RNAs such as tRNAs & tsRNAs, as illustrated in @NatureCellBio Exciting times ahead!

Think Mass Spec can't do RNA-seq & RNA modification mapping? Think again!.With the trick of generating RNA ladder (the very core of Sanger sequencing) our work with @sz2110 enables De Novo RNA-seq & mapping of multiple RNA modifications in #tRNA @J_A_C_S

RT @zhangf: Nature is amazing! Congratulations to @maxewilkinson and team on a beautiful study revealing a clever way that bacteria defend….

Big congrats Bruno! @DiStefano_Lab Honored to be part of the team!.

RT @mbarnalab: 1/9.We show that Human ribosomes have different rRNA sequences, predominantly indels. These include abundant variants such a….

RT @OdedRechavi: It took more than a DECADE. but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we buil….

RT @jinweizhang: How does one #tRNA-mimicking mascRNA from #MALAT1 get one CCA tail and is stable, while menRNA from #NEAT1 receives two ma….