Philip Johnson
@philip_johnson8
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Scientist / Professor / York University
Toronto, Ontario
Joined April 2015
Great to have this preprint now out. NMR determined 3D structure of the ligand-bound dopamine-binding DNA #aptamer. Great work by everyone involved.
Unconventional DNA architecture in a dopamine-bound aptamer complex https://t.co/KSEN4Uxhrt
#biorxiv_biochem
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Great to be part of the project!
Sharing our @ChemBioChem paper on a non-G4 DNAzyme led by visiting scholar Claudia from Mexico. 1) Opposite pH dependency to a G4 one. 2) Beautiful NMR for hemin binding despite its paramagnetic Fe. NMR collaboration with @philip_johnson8 and @RahithNY 👏 https://t.co/KixWt9NnB9
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It was an excellent time!
Had a great mini aptamer conference in Bordeaux. Good discussion, nice weather, food and wine. Heading back to Canada tomorrow😄
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The Chemistry Department at Sherbrooke will be recruiting for a new member with research interests in the domain of crystal engineering, materials chemistry or organic chemistry starting next fall! More here: https://t.co/udlOVx2p67
@Chemjobber @ChemFacultyCDN
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Join us for #Aptamers 2026 | #Oxford, UK & Online - 13th annual - the world’s premier & longest-running aptamer #conference | 23-24 Mar 26! Oral & poster abstracts invited from emerging researchers & students! Visit: https://t.co/KMh72OWZbu
#AptOx26 #NucleicAcids
@JAptamers
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A beautiful dopamine aptamer structure biology talk by Prof. Cameron from @univbordeaux_EN, followed by a joint group meeting with five students from the @philip_johnson8 group from York University. A nice aptamer day! @uWaterlooIntl
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New paper out as part of our ongoing collaboration with Juewen Liu at Waterloo. Interesting to see aptamers for ligand targets with such subtle structural differences. Great work by everyone involved @bionaloo #aptamer
Led by PhD student Yachen Xie, we obtained aptamers for bilirubin and biliverdin. Took us two years, a lot of details, check it out! Nice NMR from @philip_johnson8 and @RahithNY
https://t.co/x4ZHuW6yCi
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Happy to have been able to help you on this project Juewen!
I think this is the first time that Irving-Williams series is seen in a nucleic acid. Should be an interesting metal binding site. Check out our new paper @ChemicalScience, another good collaboration with @philip_johnson8 and @RahithNY
https://t.co/KIiWd9KtAV
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#Aptamers 2025 (Oxford) - 14-15 April - The deadline for oral abstract submission is less than two weeks ago. Submit your abstracts for pre-approval on the following link: https://t.co/xRh3p6XN0y
#AptOx25
@JAptamers
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Great to have contributed to this paper wuth Juewen Liu that came out New Year's Day in @J_A_C_S An aptamer for Sc3+ with different affinities and dissociation kinetics to rare earth elements. Congrats to all involved! @bionaloo @RahithNY
pubs.acs.org
Rare earth elements (REEs) are widely used in various high-tech industries. Developing affinity ligands that can detect and distinguish REEs is at the forefront of analytical chemistry. It is also...
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Glad to see our new @J_A_C_S paper online on New Year Day! Using Sc3+, a visiting PhD student Jin Wang obtained an aptamer with different affinities and binding and dissociation kinetics to rare earth metals. Thanks @philip_johnson8 and @RahithNY for NMR! https://t.co/CG4EpLaD0o
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Kinetic and Affinity Profiling Rare Earth Metals Using a DNA Aptamer | Journal of the American Chemical Society @UWaterloo Development of high affinity ligands that bind to rare earth elements
pubs.acs.org
Rare earth elements (REEs) are widely used in various high-tech industries. Developing affinity ligands that can detect and distinguish REEs is at the forefront of analytical chemistry. It is also...
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Excited to publish our microplastic aptamers @angew_chem. Both PVC and PS microplastics have the same aptamer, revealing a fundamental difference in surface binding aptamers and molecule binding aptamers. Check it out! https://t.co/gXzO2Y5j4Y
@water_institute
@UW_Ecohydrology
onlinelibrary.wiley.com
Through the systematic evolution of ligands by exponential enrichment (SELEX), a pyrimidine-rich DNA aptamer was isolated for PVS and PS microplastics, despite their different chemical structures....
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#Aptamers 2025 | Oxford, UK | 14-15 April 2025 Registration is open. 12th annual aptamers conference Virtual/in-person hybrid Website: https://t.co/vQryGdGBtg X: @AptamerSociety | @JAptamers | #AptOx25 Email: AptamersOxford@gmail.com
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Attention Biochemists‼️UWaterloo is hiring TWO tenure-track Assistant Professors in Biochemistry from any field. Details available here:
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Great to have been part of this work with Juewen Liu @bionaloo. And great to have an aptamer for quinine that is not the classic cocaine-binding aptamer like MN4! Thanks to Rahith @RahithNY in my lab and everyone else involved. #aptamers @ChemEurJ
we isolated a 10 nM Kd aptamer for quinine, with no binding to cocaine. Now, finally, both quinine and cocaine have their own aptamers. Another good collaboration with @philip_johnson8, an expert on this topic. Open access, free to read💥
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Happy to have our latest paper published. Congratulations to all involved! Thanks to our collaborating labs @cdmackereth @ebiosensors #ChemBioChem #aptamers @RahithNY
chemistry-europe.onlinelibrary.wiley.com
Binding and ligand-induced structure formation of a dopamine-binding DNA aptamer as a function of stem length is reported. All constructs show folding with ligand binding, but only aptamers with a...
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Be sure to read research from @bionaloo & co @UWaterloo on the possibility of obtaining buffer binding aptamers in failed SELEX Find their full report on our website👇 https://t.co/VHbCMSUVWo
pubs.rsc.org
During a typical aptamer selection experiment, buffer molecules are used at the 10 to 50 mM range, whereas target molecules could be used at much lower concentrations even in low μM levels. Therefo...
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Our latest collaboratory work with the lab of Heyu Ni is out on bioRxiv now. Congrats to Aron and the whole team! @AAronShoara @biorxiv_biochem
Structural analyses of apolipoprotein A-IV polymorphisms Q360H and T347S elucidate the inhibitory effect against thrombosis https://t.co/Cm9zVHLTdG
#biorxiv_biochem
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Great to have played a role in this work with Juewen Liu. Congrats to all involved including @RahithNY from my lab. #aptamers
We always wondered about the possibility of obtaining buffer binding aptamers for failed SELEX. Now we know it is unlikely, especially when Good's buffers are used. A nice collaboration with @philip_johnson8
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