Peter Meister
@peter_meister
Followers
447
Following
227
Media
19
Statuses
302
Genome folding, how and why. C. elegans, because genetics. Sailing, Diving, Mountains and Bird Watching.
Basel/Bern
Joined June 2009
39
72
290
Congrats to @peter_meister’ s lab. Condensin I folds C.elegans folds genomes.
nature.com
Nature Genetics - Inactivation of somatic SMC complexes in Caenorhabditis elegans shows that condensin I is the major long-range genome loop extruder, while cohesin forms small loops. Inactivation...
19
6
23
A very nice paper from @peter_meister's lab: C. elegans condensin I/IDC organizes holocentric interphase chromosomes, like cohesin in mammals https://t.co/Vat6ruqjSh
nature.com
Nature Genetics - Inactivation of somatic SMC complexes in Caenorhabditis elegans shows that condensin I is the major long-range genome loop extruder, while cohesin forms small loops. Inactivation...
1
3
13
Fascinating work on SMC complexes in worms! Latest version of the preprint is I think at
biorxiv.org
The Structural Maintenance of Chromosomes (SMC) complexes, cohesin and condensins, are named for their roles in separating and compacting chromosomes during meiosis and mitosis. Recent data from...
Preprint alert! Proud to present our new study exploring the functions of #SMC complexes in nematodes, fascinating ring-like micromachines extruding chromatin loops https://t.co/Wj6GbzrjRl. A🧵
1
2
1
(1/16) Check out our @SimonMJGaudin paper https://t.co/ZcCmKI4CFh from the Canzio lab out in @ScienceMagazine today on how tuning local cohesin trajectories enables differential readout of the clustered Protocadherin (Pcdh) locus across different types of neurons.
3
36
100
@LucaGiorgetti @vaquerizasjm And now nicely formatted here:
0
1
8
Postdoc position available in the Barrios Lab! Great science and great environment!
0
7
5
📢 Are you looking for a PhD project ranging from basic to applied research? Then join my group at #LMU. Munich is a European leader in research, education and technology and offers a wealth of leisure activities. 🏔️🌅🎡 Apply!
2
101
214
One week left to apply!
Got solid quantitative/math skills and recently finished your PhD? Your skills could turn patient big data into personalized therapies that unleash the immune system to kill cancer cells. Find out how and join us for your postdoc: https://t.co/kyGsuZOhWW
0
6
0
Hello 3D genome people! Did you know that C. elegans has a good looking cohesin but no CTCF? The newly graduated Dr. Jun Kim @JunKim51053763 decided to look at what cohesin does for the compact, 100 Mb worm genome, fitting ~20,000 genes:
biorxiv.org
In mammals, cohesin and CTCF organize the 3D genome into topologically associated domains (TADs) to regulate communication between cis-regulatory elements. However, many organisms, including S....
3
33
117
🏉 Le rugby n'a pas besoin des énergies fossiles. Notre planète non plus. Ensemble, sortons-les du terrain : likez et partagez cette vidéo ! #TotalPollution #RWC2023
151
1K
2K
I am very happy to share the first manuscript from my lab! We found that fasting induces a tissue-specific, reversible, large-scale 3D genome reorganization in #Celegans 👇 https://t.co/nGYFLqax5P
biorxiv.org
Chromatin architecture is a fundamental mediator of genome function. Fasting is a major environmental cue across the animal kingdom. Yet, how it impacts on 3D genome organization is unknown. Here, we...
2
35
130
They have amazing data on HiC at Zygotic Genome Activation as well as polymer modeling of fountains formation!
1
0
2
/21 What about fountains in other species? You can spot fountains in medaka, frog, and Zebrafish! Check out the manuscript by the team of @agalitzina @onichtchouk @leonidmirny!
biorxiv.org
The first activation of gene expression during development (zygotic genome activation, ZGA) is accompanied by massive changes in chromosome organization. The connection between these two processes...
1
0
2
/20 We would love to put the genetic tools in the nematodes to understand further the gene- and tissue-specificity of this effect!
1
0
0
/19 And indeed, the nematode homologs of genes overexpressed in CdLS neurons are significantly over-represented in the genes upregulated upon COH-1 cleavage! https://t.co/3u6ZQgmBE9 /12
nature.com
Nature Communications - A feature of cohesin mutations in patients with Cornelia de Lange Syndrome (CdLS) is intellectual disability, but the underlying mechanisms have remained obscure. Here the...
1
0
0
/18 among which Cornelia de Lange syndrome characterized by mental retardation and autism spectrum disorders. More info here: @CdLSFoundation
1
0
0
/17 We analyzed the behavior of the animals upon COH-1 cleavage in the absence of food, which triggers foraging behavior and worms do not seem to realize that there is no food anymore! This is reminiscent of cohesinopathies, human diseases due to mutations in cohesin subunits...
1
0
0
/16 Several fountains are located close to skn-1. Upon COH-1 cleavage, the two head neurons overexpress the intestinal form of the protein, highlighting dendrites and axons! Genome-wide, most genes up-regulated are expressed in neurons. If so, is neuronal function impacted?
1
0
0