Collin Ewald
@CollinEwald
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Research on diseases of aging and regenerative medicine @Novartis. Views are mine. #matreotype. VP of https://t.co/0rMO0JF7ME,P of https://t.co/U137KZ9UtI
Switzerland
Joined June 2012
Thank you @VeraBohren for this wonderful portrait and interview at #69inspiringPeople. https://t.co/v606GAO7HN
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We are seeking an #innovation-focused #postdoctoral researcher to develop and refine in-vitro protocols using #patient-derived #iPSCs for neuronal aging.
novartis.com
Explore opportunities with Novartis below. For additional roles with Novartis Gene Therapies (formerly AveXis) visit the GTx Career Search.
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I really liked the way Jan Gruber explained "biological aging" clocks at day 1 of @LongevityDublin. What should a useful clock be able to do? (1) Identify existing disease (2) Detect early, hidden and subclinical disease in an interpretable/explainable manner (3) Provide
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New brief on the Biology of Aging is out by the United Nations. Honored to be a Scientific Board Member. https://t.co/BA4vzimLeP
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Targeting DNA damage in ageing: towards supercharging DNA repair, read now our latest article in @NaturePortfolio Nature Reviews in Drug Discovery. @ArBujarrabal @George_Garinis Paul Robbins Jan Vijg @CECAD_ @UKKoeln Free access to the article here: https://t.co/T2rX40orEC
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New BSRA seminar incoming! On June 26 at 4pm UK time, we’re joined by Dr Della David (@BabrahamInst) for a deep dive into: “Strategies to Mitigate Age-Dependent Protein Aggregation” Free + open to anyone interested in ageing biology. https://t.co/RWZpVuwjSu
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Wonderful talk by @jangruber467 who was able to model a mystery from my former lab. If its all damage accumulation, how can the lifespan of C. elegans be doubled at the end of life? A physics derived model can explain it!
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Exciting science on your end-of-year wish list?!? >> apply to our postdoc and PhD positions and start 2025 with a new job @UniBasel
Please RT: we have @snsf_ch -funded #Postdoc and #PhD positions in our lab, to investigate the gene regulatory dynamics during vertebrate skeletogenesis in a comparative setting (see https://t.co/BmfkQc7Rz6 and https://t.co/MaIz2UKwYK ) - apply by 31.12.24, start date by 1.2.25!
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#ARDD2024 Collin Ewald at ARDD2024: Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age https://t.co/Sio0na26lb
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We are looking for a #physiologist to study how the age-related decline of organ homeostasis, and associated changes in #metabolism and #endocrine systems cross-talk contribute to #diseases of aging across the core therapeutic areas of @Novartis. Desirable #ECM #aging knowledge.
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Congrats to @peter_meister’ s lab. Condensin I folds C.elegans folds genomes.
nature.com
Nature Genetics - Inactivation of somatic SMC complexes in Caenorhabditis elegans shows that condensin I is the major long-range genome loop extruder, while cohesin forms small loops. Inactivation...
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@LucaGiorgetti @vaquerizasjm And now nicely formatted here:
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Roles for matrix/basement membrane proteins nidogen and laminin in sensing touch. C. elegans touch receptor neurons direct mechanosensory complex organization via repurposing conserved basal lamina proteins https://t.co/7THbbKSEv4
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📢New Open🔓Access Article Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age by Adrian Molière & Collin Y. Ewald (@CollinEwald) et al. https://t.co/8PWyr0sPPN
#endoflife #frailty #insulin #IGF1 #longevity #proteinhomeostasis #resilience
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Quality of supplements targeting aging: Testing the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim | GeroScience ( https://t.co/73DWwUTeJj)
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Registration closes this Friday, 21 June! 📣 We are looking forward to welcoming you in #Mainz next week. ➡️ https://t.co/aHyxs9E3le
#alternsforschung #ageingresearch
1 more month to register for the "Annual Meeting of the German Association for #Aging Research". Taking place 27-28 June at IMB. ➡️ https://t.co/aHyxs9E3le
#alternsforschung #ageingresearch
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This study raises the possibility that the effect of #IIS and related pathways on resilience and frailty during aging in higher animals might possess some degree of reversibility. @GeroScienceAGE 🍬🔬👵 @AdrianMoliere @CollinEwald et al. https://t.co/skhylygzWT
link.springer.com
GeroScience - Little is known about the possibility of reversing age-related biological changes when they have already occurred. To explore this, we have characterized the effects of reducing...
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Kudos to @AdrianMoliere, @ParkisLaelaps, and the team for pushing this over the finish line. I'm so happy this work got published! It looks like end-of-life doubling of lifespan upon daf-2 degradation potentially via restoring #protein #homeostasis.
It’s never too late: Our new paper explores how auxin-mediated DAF-2 degradation still massively extends lifespan even at a very old age. A short 🧵 #Aging #GeroScience #AgingResearch
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Big thanks to @GeroScienceAGE, @CollinEwald, and all the collaborators for this amazing project: @ParkisLaelaps, @Anita, Elena M Vayndorf, Bruce Zhang, Kuei Ching Hsiung, Yoonji Jung, Sujeong Kwon, Cyril Statzer, @Meyer_DH, Richard Nguyen, Joseph Chadwick, @Max_t88
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