Rob Moran
@pRobM91
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Research Fellow at University of Birmingham. I like plasmids. Co-founder of @ContamClub
Birmingham, England
Joined June 2019
‼️🚨🗓️ CONTAMCALENDAR 2025 🗓️🚨‼️ The ContamCalendar is back for another year! It’s a great one and we hope you’ll love it 🗓️🦠🧫🍄 Get yours here ➡️ https://t.co/OdL6DX4gU9 ⬅️
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Happy Noodlococcus Day to all those who celebrate 🍜🦠 On this day in 2019, we discovered this noodle-y colony contaminating an old plate, leading to the creation of ContamClub 🧫✨
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This project has been my first using only long-read sequence data (ONT 10.4.1) - it's been great - makes my days of assembling plasmids from short-read data + molecular work seem like a very long time ago...
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It's been evolving in the hospital through the actions of smaller MGEs We've seen IS26-mediated inversions and acquisitions of various IS/transposons, including carriers of heavy metal resistance genes
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pQEB1 carries the KPC-2 carbapenemase gene, and has been found in multiple bacterial hosts - genera, species and STs Its precise structure is unique and has yet to be seen outside England's West Midlands
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Out latest preprint describes a plasmid lineage we've been tracking in Birmingham's QE Hospital - short 🧵👇 https://t.co/ERhXj57ebb
@alanmcn1
biorxiv.org
While conducting genomic surveillance of carbapenemase-producing Enterobacteriaceae (CPEs) from patient colonisation and clinical infections at Birmingham’s Queen Elizabeth Hospital (QE), we identi...
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A new publication from my PDRA with @alanmcn1. Working with our UK-India collaborators, we screened the ability of non-antibiotic pharmaceuticals to cause genetic changes and cross-resistance to antibiotics (spoiler, not so much). https://t.co/rT1DJq3OcC
nature.com
npj Antimicrobials and Resistance - Non-antibiotic pharmaceuticals are toxic against Escherichia coli with no evolution of cross-resistance to antibiotics
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I'll have some limited @ContamClub merch on hand too!
Plasmid folk at #microbio24 - I'll be at B090 with a bonus poster showing some very new work, tracking plasmid lineages in a Birmingham hospital with long-read sequencing. Stop by if you'd like to hear more!
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Plasmid folk at #microbio24 - I'll be at B090 with a bonus poster showing some very new work, tracking plasmid lineages in a Birmingham hospital with long-read sequencing. Stop by if you'd like to hear more!
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If you're at #MicroBio24, come and visit posters B080 and B090 during the poster sessions, we've got some Contam Calendars and stickers to give out! 🦠
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If you're plasmid inclined, don't miss this!
I’m talking about metabolism and MDR at 14:45 today, come along if you’re at a loose end! #microbio24
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Izzie is an amazing PhD student in the McNally lab, definitely recommend going to see her!
A great week at #Microbio24 so far, excited to present the start of my PhD work on conservation and variation in E. coli core genes at poster B052
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Ryan is an excellent presenter and he’s working on some really cool things, definitely recommend checking out his poster!
Presenting a poster on my efforts at characterising metagenomes with De Bruijn graphs. Drop by poster B008 (delightfully palindromic) at #Microbio24 if you're keen to chat more!
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I’ll be presenting my poster today on in vitro evolution of Enterococcus at #Microbio24 come along to poster B055 if you want to find out more!
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Very happy have this out! I’ve been working on a couple of projects since joining @alanmcn1 and this is one of them - looking at the transcriptional response to multidrug resistance plasmids in E. coli. Thanks @AnnSnaith for the help on this too! https://t.co/fj8elN8m5s
journals.asm.org
The increase in infections that are resistant to multiple classes of antibiotics, including those isolates that carry carbapenamases, beta-lactamases, and colistin resistance genes, is of global...
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The new pre-print from the @GraingerLab! Really cool work mostly done by the talented @mulecc. Charles noticing a strange grey colony snowballed into this great story.
H-NS is a bacterial transposon capture protein https://t.co/wIEizuOKA5
#biorxiv_micrbio
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Excellent work from @DETECTIVE_AMR consortium. Big shout for @IbrahimxBa @pRobM91 and @DrEmmaDoughty and colleagues in China. Also leadership of @alanmcn1 and @WvSchaik
nature.com
Nature Communications - In this work, the authors identified a hypervirulent carbapenem-resistant Escherichia coli ST410 clone which carries a high pathogenicity island and an O-antigen gene...
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🔔New Pre-print🔔 TL;DR: The opportunistic pathogen A. lwoffii is more constrained in acquiring & developing antibiotic resistance 🦠 @JessicaMABlair @pRobM91 @friendlymicrobe @babs_clough @roscobacterium @FrickelLab @ma_webber
https://t.co/yypSlkmS5N
biorxiv.org
The two species that account for most cases of Acinetobacter -associated bacteraemia in the UK are Acinetobacter lwoffii , often a commensal but also an emerging pathogen, and A. baumannii , a...
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Fun fact about this year's ContamCalendar - it was created entirely from a hospital bed after I spent 7 weeks in hospital following heart surgery. This surgery was actually partially related to both contamination and the ContamCalendars.... 📆🫀🩺🦠
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Introducing the ContamCalendar 2024 📆🦠🧫🍄 on sale tomorrow! Loved putting this together, can't wait for you guys to get your hands on this 💥 Retweet, like, and follow @ContamClub for your chance to win one 💥
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