Olivier Parent
@oparent41
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PhD candidate - Integrated Program in Neuroscience @IPNMcGill - Centre d'imagerie Cérébral @DouglasResearch
Montréal, Québec
Joined August 2015
After 3 years of "just one more analysis", happy to share our preprint! Building on previous post-mortem findings of non-vascular WMHs, we identified a specific signature of neurodegenerative WMHs in vivo using microstructural MRI and normative modeling https://t.co/H8m0V3w4KB
medrxiv.org
White matter hyperintensities (WMHs) are neuroimaging markers widely interpreted as caused by cerebral small vessel disease, yet emerging evidence suggests that a subset may have a neurodegenerative...
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After 3 years of "just one more analysis", happy to share our preprint! Building on previous post-mortem findings of non-vascular WMHs, we identified a specific signature of neurodegenerative WMHs in vivo using microstructural MRI and normative modeling https://t.co/H8m0V3w4KB
medrxiv.org
White matter hyperintensities (WMHs) are neuroimaging markers widely interpreted as caused by cerebral small vessel disease, yet emerging evidence suggests that a subset may have a neurodegenerative...
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... and twitter-less Sophia Osborne, Manuela Costantino, Daniela Quesada, Alexandre Pastor-Bernier, Alfonso Fajardo-Valdez, Alexa Pichet-Binette, Ann McQuarrie, Josefina Maranzano, Christopher Steele
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Huge thanks to all who have supported and helped this project @zklsmr @AurelieBussy @JeremieFouquet @gadevenyi @sylv_villeneuve @DadarMahsa @mallarchkrvrty1 ...
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If you’re into rodent fMRI, you should definitely check this work led by Mila Urosevic! A great resource for anyone developing an acquisition protocol and who wants to improve measurements of resting-state networks.
Evidence-based guidelines for improving network detectability in rodent fMRI https://t.co/U8ZcVayQ4Q
#biorxiv_neursci
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My paper introducing my longitudinal DBM pipeline and examining the ultimate sensitivity of it in human data is now published at ApertureNeuro! https://t.co/d50Yz6wQ4f
apertureneuro.org
By Jurgen Germann, Flavia Venetucci Gouveia & 2 more. Here, we present a two-level DBM technique, where the Jacobian determinants are first calculated at the subject level, followed by co-registrat...
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Racial and ethnic differences in white matter hypointensities: The role of vascular risk factors - Alzheimer's & Dementia - Wiley Online Library https://t.co/k56raXQZix
@farooqkamal_1 @CassMorrison01 @roqmoqadam
alz-journals.onlinelibrary.wiley.com
INTRODUCTION White matter hypointensities (WMHs) are markers of cerebrovascular pathology associated with cognitive decline. Reports of racial and ethnic differences in WMHs have been inconsistent...
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Frontotemporal dementia subtyping using machine learning, multivariate statistics and neuroimaging
academic.oup.com
Metz et al. report that machine learning can effectively differentiate frontotemporal dementia subtypes, combining brain atrophy patterns and cognitive per
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New paper led by @AurelieBussy now out in Neurobiology of ageing. We use non-negative matrix decomposition using morphological and qMRI measures (T1, T2*) to understand the relationship between GM and microstructure in the Alzheimer's spectrum. https://t.co/9sN8Pr70m7
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It’s out! 🎉 Check our paper “Disentangling the effect of sex from brain size on brain organization and cognitive functioning” 🧠, where we explored sex differences in the brain while removing the effect of brain size differences. 1/10
📢New Recommended Reading 📖 Disentangling the effect of sex from brain size on brain organization and cognitive functioning by Aliza Brzezinski-Rittner (@AlBRzez) & Yashar Zeighami et al. https://t.co/IqUqiuxGIU
#brainmorphometry #Sexdifferences #aging #magneticresonanceimaging
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Delighted to see this work, led by Matt Danyluik, out in @ImagingNeurosci Excellent technical piece on the caveats of methods for performing inference using PLS. A great piece of work for those using the technique and those who are interested in its robustness and reliability
New paper in Imaging Neuroscience by Matthew Danyluik, M. Mallar Chakravarty, et al: Evaluating permutation-based inference for partial least squares analysis of neuroimaging data https://t.co/XS3KFVd2nx
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TLDR: When age-matching pre- and post-menopausal women in UK Biobank, we don't find an effect of elevated WMHs after menopause! Hopefully this brings nuance to the field and motivates the acquisition of data purposefully designed to investigate women's health in aging
Really excited to share this preprint. Born from the hard work of visiting student Denise Wezel (Frei U. Amsterdam) and @oparent41, we examine the relationship white matter hyper intensities (ie neurovascular pathology) and the menopause transiton. https://t.co/m9WL2AHYH5
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Just putting it out there again we're hiring for 1) Scientific programmer 2) Immunohistochemistry technician RT's appreciated! Feel free to DM or email me if you have questions!
📢📢 We're hiring!! Looking for two motivated individuals to work us. 1) a scientific programmer to software dev in the group! https://t.co/4a7bC7WlOZ 2) somebody interested in supporting immunohistochem work! https://t.co/hk3FsBqD3P RTs pls @DouglasResearch @TRIDENTPCT
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5 years ago, on the heels of 28andMe, our team designed a new precision imaging experiment: scanning an individual’s brain throughout her entire pregnancy. We are excited to share that these findings are out today in @NatureNeuro!
nature.com
Nature Neuroscience - Neural changes in pregnancy are not well understood. Here Pritschet et al. present an open-access precision brain imaging resource, mapping neuroanatomical change in an...
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Here’s some new work from the group from Tyler Agyekum This papers got some hippocampus, some microstructure, some ageing, and some great multivariate analysis!! 👇🏾👇🏾 https://t.co/CZCnHcvxCZ
biorxiv.org
Ageing is a biological process associated with the natural degeneration of various regions of the brain. Alteration of neural tissue in the hippocampus with ageing typically results in cognitive...
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When you abuse for-loops in UK Biobank and generate a comically large graph that needs to be 8 feet wide to be readable, you gotta print it! Now the whole lab can look at the white matter hyperintensity patterns of 646 different diagnoses in UK Biobank!!
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RABIES is officially out in @NatureComms, check it out https://t.co/qaEsWbV6Kg! Many many thanks to @gadevenyi, @grandjeanlab and my supervisor @mallarchkrvrty1 for getting us there. It was well worth the patience and hard work!
Major updates on the RABIES preprint are out https://t.co/XEf7WKfSqA! In this work by @gadevenyi, @grandjeanlab, @mallarchkrvrty1 and I, we introduce the RABIES pipeline ( https://t.co/j16NCibUhl), our effort in offering standardized tools for the rodent fMRI community.
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Evaluating permutation-based inference for partial least squares analysis of neuroimaging data https://t.co/XWHWQhZSqb
#biorxiv_neursci
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That was unexpected! Huge thanks to @NeuroimagingPIA for this award, and congrats to the other winners! If you want to chat about WMH pathophysiology and a potential signature of non-vascular neurodegeneration-related WMHs, come by my poster Tuesday-442 #AAIC2024
And congratulations to the winners of the poster competition and oral awards-- great presentations Anna Steward, Margo Heston and Olivier Parents 🎁 and thanks to all presenters allround!!⭐️
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