Yu-ichiro Nakajima
@nyuichiro97
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Biologist, studying tissue homeostasis, environmental responses, cellular plasticity 🪰🪼 Like sports & cooking. 恒常性, 環境応答, 細胞可塑性の研究@東大薬学
Tokyo, Japan
Joined May 2016
We recently uploaded a new preprint exploring the mechanism of organ remodeling during dormancy. https://t.co/QCROsh4bSf Yuya, a student in my group, used the fly model to identify a novel role of BubR1 and Mad2 in pausing stem cells in a “ready-to-go” state, enabling the
biorxiv.org
Diapause is a survival strategy in which growth and aging are temporarily suspended, enabling animals to withstand unfavorable environments. Various insects, including the fruit fly Drosophila ,...
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効率的なDNA挿入技術の開発 リコンビナーゼを用いて、タンパク質進化、機械学習、dCas9との融合などによりDNA配列の効率的かつ特異的な挿入を実現。キロベース単位でのDNA挿入が可能で、幹細胞やT細胞など複数の細胞種に導入可能 https://t.co/NijGuheYFt
nature.com
Nature Biotechnology - Engineered DNA recombinases efficiently and specifically insert genetic cargos without the use of landing pads.
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AIがどれだけ機能的なRNA配列を生成できるようになるのかとっても気になる昨今。国内の動向ですが、遺伝研で、近藤滋さんの音頭取りでバイオ生成AIプロジェクトが進んでいます。こちらから登録すれば定期的に開催されているバイオ生成AI研究会に参加できます���次回は11/14。 https://t.co/8RE1jxNZ5j
ds.rois.ac.jp
我が国の大学等のデータ駆動型研究の支援と機能強化に貢献します。
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タンパク質切断の特異性をプログラムする 細菌細胞にとって毒性を持つタンパク質(ガスデルミンD)に任意の配列を結合。切断されたときに細胞が生存する性質からプロテアーゼのタンパク質進化に利用。疾患の原因となるタンパク質を切断するプロテアーゼの開発に成功。 https://t.co/PY3678FOHF
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寒い季節になると食べたくなる肉まんは毎回この温め方..... マグカップに1cmの水を入れて600Wで2分ぐらいチンすると中華街顔負けクオリティのフッカフカ肉まんが食べられます。
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Pleased to share our latest paper in @CurrentBiology! We present the first chromosome-level genome of a phoronid and show that shared chromosomal fusions place phoronids and bryozoans as sister groups, resolving a century-old debate on lophophorates. https://t.co/oswu6xuvgf
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A molecular, spatial and regulatory atlas of the Hydra vulgaris nervous system Read this #LifelongDevSI #OA Techniques and Resources Article by Hannah Morris Little, Abby S. Primack (@ProtozoaPrimack), Jennifer Tsverov, Celina E. Juliano and colleagues: https://t.co/PTlkl1dapK
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Affinity Studio(Photoも)無料化!!! これで研究者もPhotoshopから卒業しない理由がなくなったな! 値上げばかりの世の中にあってありがたい 出来れば関連製品を買ってお返ししたい
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High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes - @PKU1898
https://t.co/lqj9yeq40H
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Rの基礎から応用(Quarto,GIS,ネットワーク分析,Shiny)まで体系的にまとめている,網羅的なWEB教科書だと思います. R入門 https://t.co/17t9kMW35G
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Had the pleasure of working with @Dardiry_mo to rethink what it means to develop for life. Many thanks to @Dev_journal! @embl #LifelongDevSI
Phenotypic plasticity as the foundation of lifelong development In this #LifelongDevSI Hypothesis, @Dardiry_mo and @AissamIkmi (@embl) challenge the paradigm of organismal terminal differentiation https://t.co/L5kwjDYkB8
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• Limb loss triggers a body-wide activation response that kickstarts regeneration • This response requires sympathetic innervation and adrenergic signaling • Uninjured distant tissues keep a "memory" of the amputation so they can respond more quickly if they are later injured
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Axolotls use adrenaline signaling to regenerate legs! Today, we can finally share the official publication of a really exciting project we've pursued over the last several years. Thanks to the entire team for their creativity, expertise, and work.
cell.com
The nervous system regulates a systemic response following amputation that primes distant appendages for faster regeneration upon a second injury, a scenario relevant to salamanders in the wild who...
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Very impressive effort. Clearly where all GWAS papers are headed - to go from just genes near loci to characterizing biology all across the causal chain. Haven't seen it done as comprehensively as this tho, https://t.co/ReMgA8lNHI
nature.com
Nature - The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
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Age-related mutations give sperm-forming stem cells a selective advantage during sperm production, shaping disease risk and genetic variation in offspring https://t.co/w2pWRExbh1
nature.com
Nature - Age-related mutations give sperm-forming stem cells a selective advantage during sperm production, shaping disease risk and genetic variation in offspring.
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最先端のAIを活用した論文検索・執筆支援AIを用途別に整理しました。ブックマーク推奨👇 ⭐️FutureHouse 用途に合わせた複数のAIサイエンティストが搭載。元Google CEOのEric Schmidtも資金援助しているAIの科学研究をする非営利団体。 ✅ChatGPT Deep Research
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Anthropicが生命科学研究ツール「Claude for Life Sciences」を発表! 以前から「生成AIにより研究の大部分が代替される」と発信してきましたが、その本丸だと思います。 最終的に研究者の仕事は、 1.解き明かしたい「問い」を定める 2.質の高いデータの取得 くらいしか残らないと考えています。
We’re building tools to support research in the life sciences, from early discovery through to commercialization. With Claude for Life Sciences, we’ve added connectors to scientific tools, Skills, and new partnerships to make Claude more useful for scientific work.
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【ChatGPT Atlasブラウザによる論文読解決定版!】 これは凄いです! ChatGPT AtlasブラウザでPaperpileを開く →ChatGPTタブでPaper Interpreter起動 →要約結果を論文PDFに貼り付け その後もPaper Interpreterとのやり取りを全てメモとして保存できる! 現段階における論文読解の決定版です!!
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How to develop good research questions https://t.co/XIjlYux0hC
#MedEd #MedX #Science #phdlife #PHD #AcademicTwitter #academicWriting
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