Nicolas Vabret
@neoviral
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Assistant Professor @SinaiImmunol @MountSinaiNYC #Immunology #Cancer Also @neoviral.bsky.social
New York, USA
Joined February 2014
Check out our highlight of an exciting new preprint by Dr. Claudia Rivera from Yasmine Belkaid's group! @neoviral @preprintclub 👇
Retroelements orchestrate gut tolerance
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Check out our latest in @trendscancer where rockstar PhD student Laura Rosenberg reviews cancer therapies known to induce innate immune responses via the sensing of Transposable Elements. https://t.co/eEvPtWcv4D
cell.com
Viral mimicry is a cellular state in which the reactivation of silenced transposable elements (TEs) leads to the accumulation of immunogenic nucleic acids, triggering innate immune pathways that...
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T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below https://t.co/VgTByRKRCX
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Registration is now open for the next ImmunoSchool! This year’s theme: "10 Years of Discovery in Immunotherapy." We’ve put together a stellar lineup of speakers—don’t miss it! Free registration @ https://t.co/ImzZu9eJ4V
#ImmunoSchool #Immunotherapy #CancerResearch
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Exposure to sugar rationing in the first 1000 days of life protected against chronic disease | Science
science.org
We examined the impact of exposure to sugar restrictions within 1000 days after conception on type 2 diabetes and hypertension, leveraging quasi-experimental variation from the end of the United...
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👻🎃 Shoutout to my amazing PhD students for dressing up as their -not- favorite lab techniques. Happy Halloween!
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#Hub1 will follow with Laura Rosenberg from @SinaiImmunol who will present a #preprint by @andyjminn lab about how targeting interferon can prevent epigenetic evolution and resistance to cancer immunotherapies 🎯💉🧬 👇 https://t.co/MZnvScm3ub
biorxiv.org
Acquired resistance is a growing obstacle to durable responses after cancer immune checkpoint blockade (ICB). The mechanisms by which heterogeneous tumors evolve under immunotherapy pressure and...
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Hub#1 is back TODAY 🥳 we will start with Arthur Mortha @nkg2d1 from @ImmunologyUofT , who will present a #preprint by @BecherLab and @SarahMundt5 labs about the role of monocyte-derived cells in oxidative tissue damage in neuroinflammation 🤯💥🩹 👇 https://t.co/MTjwMxGbmZ
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📜#INFLAMMAGING STUDY📜Aging is the main risk factor for cancer. In @ScienceMagazine, @MatthewD_Park & @MiriamMerad describe how an aging hematopoietic system fuels myeloid dysfunction and inhibits control of lung tumors, raising new treatment options 👇 https://t.co/7kooZTjRQu
science.org
Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In this study, we establish that aging of the immune system, regardless of the age of the stroma and tumor,...
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Adaptive immunity to retroelements promotes barrier integrity https://t.co/Ftf5mM8V0f
#biorxiv_immuno
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JOIN US Oct 3 in NY for: Next Generation Immunotherapy Discoveries, a symposium on innate immunology & more, organized by @EricVivier1 @InnatePharma @MiriamMerad, with lunch & cocktail reception. Limited spaces available. Don’t miss out! REGISTER FOR FREE https://t.co/dcr7oJMghI
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While all of our body’s systems deteriorate over time, #ImmuneSystemaging has a particular impact on the health of our #CardiovascularSystem. Learn More from @cam_phd, @neoviral & @SwirskiLab in @sciencemagazine's Frontiers of Medical Research: Immunology: https://t.co/Jllqjy0XXD
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Competition between two HUSH complexes orchestrates the immune response to retroelement invasion
cell.com
The HUSH complex, composed of TASOR, MPP8, and Periphilin, facilitates epigenetic silencing of retroelements. Danac et al. now describe HUSH2, centered around the TASOR paralog TASOR2, which repres...
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@ScienceMagazine @MiriamMerad How does immune aging affect our ❤️🩸cardiovascular system and beyond, and how can we protect ourselves? Find some of the answers in an essay by @SwirskiLab @cam_phd and @neoviral, starting on page 5 >>>
science.org
How are scientists rethinking immunotherapy?
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If complete modified nt substitution abrogates IFN-I responses and is compatible with RdRp, why haven't we found viruses exploiting this as escape strategy?
Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency https://t.co/ksnnn2f4Ka
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Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency https://t.co/ksnnn2f4Ka
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Pleased to share our latest work from @MiriamMerad lab @SinaiImmunol, where we try to address the Q: Do tumors alter the epigenetic state of myeloid progenitors in marrow, and are certain aspects of immunosuppressive mono-macrophage fate sealed before they enter the tumor?🧵
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Impressive potency of chemo-free #immunotherapy as 1st-line treatment for #lymphoma with 85% complete remission rate... w thanks to the patients, families, and clinical research team @MountSinaiNYC and around the world. https://t.co/14ZFZuyen3
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