A new mechanism for “RNA memory”! 😱 Thrilled to share another crazy paper from the lab (can’t believe we posted 2 in 2 days!), summarizing >10 years of research: Work on transgenerational inheritance of small RNAs in the powerful model organism C. elegans changed how we think

Extracellular vesicles carrying microRNAs can predict kidney decline and cardiovascular risk in CKD, offering a minimally invasive tool for earlier risk stratification. - @sciencetokyo_en

The first physical evidence that mitochondria exchange information with one another transformed how I think about these beautiful organelles. From isolated beans to social collective. In 2015, we discovered that the inner membranes of mitochondria, where the oxygen we breathe

Today we discuss the remarkable fact that pieces of mitochondrial DNA translocate and insert into the nuclear genome--including in the human brain as we age. Mitochondria contribute to shaping behaviors through energy transformation and dozens of different signaling pathways.

Today RNA may seem overshadowed by its glamorous cousin DNA, but many scientists think RNA molecules were the star players in the origin of life. By both storing genetic information and copying themselves, they might have touched off the march of evolution that produced

AI is cool and all... but a new paper in @ScienceMagazine kind of figured out the origin of life? The paper reports the discovery of a simple 45-nucleotide RNA molecule that can perfectly copy itself.

🌟Presenting Our Article Paper🌟 "#miRNA Library Preparation Optimisation for Low-Concentration and Low-Volume Paediatric Plasma Samples" from Oenone Rodgers et al. @WWIEM_QUB #ncrna #paediatric @MDPIOpenAccess Full text: https://t.co/iTGusAbK9B

Full paper here:

Mitochondria are not just power plants. They are decision-makers. They regulate inflammation, aging, and disease. A quick breakdown: 🔵 Energy signaling, not just energy production Mitochondria don’t just make energy. They decide how energy is produced, where it’s used, and

Mitochondria coordinate far more than ATP. 🔻 Cytochrome c → apoptosis 🔷 H₂O₂ → redox + protein thiol signaling 🔴 NADH/NAD⁺ → integrated stress response 🔺 AMPK → metabolic/catabolic shift 🧬 mtDNA/mtRNA → innate immune activation 💠 TCA metabolites → chromatin +

Happy holidays!🎄

Mitochondrial dysfunction in cellular senescence: a bridge to neurodegenerative disease https://t.co/o0jMJ7vsZj

Molecular mechanisms modulating beneficial plant root-microbe interactions: What’s common?

I'm super pleased to share that SegmentNT, our single-nucleotide resolution genome annotation model, has been featured in Nature Methods! 🚀 SegmentNT builds on our Nucleotide Transformer foundation model to deliver on the ultimate task: single-nucleotide resolution

📖 Read the full story in our blog: https://t.co/mp08NWVxIE 🔍 Dive into the paper in @NatureMethods:

Multifaceted and multifunctional mitochondria

Happy to have played a small part in this great work led by Élena Morin, Emmanuel Doumard, Mathieu Vigneault and Jean-Philippe Pradère: EMito-Metrix enables automated evaluation of mitochondrial morphology across species | Nature Metabolism

New Online! The new era of single-molecule RNA modification detection through nanopore base-calling models https://t.co/4QzxowoU6b

Three new AI/data for biotech papers that I think are interesting: 1. MetaGraph is a huge search engine for biological sequences; DNA, RNA, and proteins. The amount of DNA sequencing data was doubling every 7 months back in 2016. Nobody seems to have measured this growth rate

Online now: Protocol for measuring mitochondrial respiratory capacity from buccal cell swabs https://t.co/pHmpUloIux #protocol #starprotocols #cellpress