Moreaux Jérôme
@moreauxjerome
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Professor at @FacultemedMPL @umontpellier, Sr Member at @InstUnivFr. Studying Plasma cell #myeloma #lymphoma biology at @IGH_MTP and @CHU_Montpellier.
Montpellier
Joined June 2011
Excited to share our latest work @Nature! We show that the total number of hematopoietic stem cells (HSCs) in the body is restricted, challenging the classical model that HSC numbers are determined locally by the niche and introducing a new paradigm. (1/9) https://t.co/kvFqNQ8Nxb
nature.com
Nature - Haematopoietic stem cell numbers are restricted at both systemic and local levels.
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Excited to share our comprehensive pan-cancer analysis of the tumor microenvironment. Led by @BhavneetBhinder, @PaulSpellman13 & collaborators, we mapped the TME of >10,000 tumors, revealing 41 distinct immune/stromal patterns and their link to survival https://t.co/FeBNGwqBnL
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An AI model developed by Google DeepMind could help scientists make sense of the non-protein-coding part of the genome https://t.co/hTIoOFDJsT
nature.com
Nature - Tool aims to solve the mystery of non-coding sequences — but is still in its infancy.
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Trispecific antibodies in myeloma! Sham Mailankody (@MSKCancerCenter) presents on JNJ-796353222 and multi-antigen targeting at #iwCART25. A new approach to overcoming resistance in myeloma! 💥🧬 #Myeloma #TrispecificAntibodies
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#Myeloma Paper of the Day: Targeting the ABCD1-ACOX1-MET/IGF1R axis suppresses myeloma, in part by promoting the accumulation of very long chain fatty acid-containing cerebrosides, revealing a specific metabolic vulnerability: https://t.co/zWYOTTsepu.
#mmsm
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Single-cell analysis of neoplastic plasma cells identifies myeloma pathobiology mediators and potential targets
pubmed.ncbi.nlm.nih.gov
Multiple myeloma is a clonal plasma cell (PC) dyscrasia that arises from precursors and has been studied utilizing approaches focused on CD138+ cells. By combining single-cell RNA sequencing (scRNA...
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#Myeloma Paper of the Day: Study of germline predisposition in myeloma finds candidates in 9.1% of sporadic & 18% of familial cases; implicated genes were DIS3, EP300, KDM1A, USP45, ATM, BRCA1/2, CHEK2, PMS2, POT1, PRF1, TP53, BRIP1, EP300, & FANCM: https://t.co/t7tVrGG6jc.
#mmsm
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After Musk & stoping this platform for a while, Here I am: Sharing My first thread in bluesky :) about our new preprint of the lab. Music ON! New method: #SNUPR #Bortezomib #MultipleMyeloma Share 🙏 https://t.co/AkbVqSe7OM
@GiganPaul @moreauxjerome @srocchi1
@CNRS_dr12
I heard that scientists are boring and that 🟦 sky will not work because of that.. It took me a while: Tomorrow, I will do my 1st post in 🦋sky (same user name). Let´s prove them wrong :)! Enjoy and Share! Tomorrow: Pre-print + video&music & figures A teaser: Music ON!!
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Happy to share the last paper of the group: Targeting Transcription-Replication Conflicts using G-quadruplexes sta... https://t.co/wA2WmqDLQx
@IGH_MTP @CHU_Montpellier @umontpellier @InstUnivFr #myeloma Many thanks to all the co-authors and sponsors.
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EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function https://t.co/r87Zzu3Bog
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Online Now: Plasma cell and cancer stem cell crosstalk in glioblastoma https://t.co/5BK4JfdnY8
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sBCMA, surface antigen density, effector-to-target ratio, and TCE dose collectively mediate primary refractoriness to anti-BCMA TCE. https://t.co/Xk4figyydx
#immunobiologyandimmunotherapy #lymphoidneoplasia #multiplemyeloma
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#Myeloma Paper of the Day: Expanded tumor-associated polymorphonuclear myeloid-derived suppressor cells in #Waldenstrom macroglobulinemia display immune suppressive activity through a direct T cell inhibition: https://t.co/yfMAvC4grH.
#wmsm
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We are pleased to inform you that the meeting “From Genome Instability to Cancer: A tribute to Angelos Constantinou” that will take place in Carry-Le-Rouet from March 10th to March 13th 2025 is now open for registration on the link: https://t.co/ysMXHk7ApK
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Our new study @SpringerNature @MolecularCancer reveals epigenetic markers at birth linked to pediatric leukemia! This breakthrough offers hope for early diagnosis & targeted therapy. See how we’re tracing cancer origins back to birth! #PediatricCancer
link.springer.com
Background Cancer is the leading cause of disease-related mortality in children. Causes of leukemia, the most common form, are largely unknown. Growing evidence points to an origin in-utero, when...
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"5th Annual Meeting on Advances on Nuclear Topology and 3D Chromatin Architecture in Cancer" A virtual meeting announcement for people interested in chromosome organization and cancer. To register use the QR code in the flyer attached, or use this link: https://t.co/DSe8xnuyyD
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Transient EZH2 suppression by Tazemetostat during in vitro expansion maintains T-cell stemness and improves adoptive T-cell therapy
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Dupéré-Richer and colleagues reveal a role for KDM6A in myeloma immune evasion and open the door for epigenome targeting to restore immune surveillance and tumor recognition in myeloma. KDM6A controls immunogenicity in MM
ashpublications.org
In this issue of Blood, Dupéré-Richer et al1 show that the histone demethylase KDM6A directly regulates the immunogenicity of multiple myeloma (MM) cells a
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