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Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ Profile
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ

@mikhailshapiro

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Bio-Acousto-Magneto-Neuro-Chemical Engineer Max Delbrรผck Professor @Caltech Investigator @HHMInews Fulbright-Tocqueville Chair @PhysMedParis @ESPCI_Paris '24-5

Pasadena, CA
Joined June 2009
Don't wanna be here? Send us removal request.
@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
16 days
Congrats to Dr. Kathy Cheung @kathycheungym on defending her PhD in neurobiology @Caltech! ๐Ÿฅ‚ Kathy fearlessly combined genetic tools, genomics, optics, ultrasound and behavior to figure out how fear ๐Ÿ˜ฑ scales in the brain. Fun to co-advise w/David Anderson.
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
2 months
RT @BTolooshams: We have released VARS-fUSI: Variable sampling for fast and efficient functional ultrasound imaging (fUSI) using neural opeโ€ฆ.
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
3 months
Fun to host the lab in Paris ๐Ÿ‡ซ๐Ÿ‡ท for the EuroBUS mini-conference!
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
3 months
Congratulations to Dr. Erik Schrunk on defending his PhD in Chemical Engineering @Caltech! ๐Ÿพ Erik added programmable covalent functionality to #gasvesicles to map their location in cells and spatially actuate chemistry. ๐Ÿงช
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
3 months
A big step forward for biomolecular ultrasound! ๐Ÿ”Š.Congrats @bgheiles, @DMarescalab at @tudelft and collaborators! #gasvesicles.
@ScienceMagazine
Science Magazine
3 months
A new method reported in Science allows the generation of 3D ultrasound images of gene expression and 2D ultrasound images of capillary vessels. The approach enables fast, deep, and volumetric imaging of living opaque organs labeled with echogenic reporters. Learn more in this
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
5 months
Fun to stop by Amsterdam for a daytime beer sip celebrating Prof. @DMarescalab's tenure promotion at @tudelft! ๐Ÿป
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
5 months
RT @srikosuri: Itโ€™s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendrโ€ฆ.
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
5 months
We're recruiting a technician to help with our work on neurons! ๐Ÿง  Great opportunity to work with @di_wu_ and other awesome scientists @Caltech. Please RT.
@di_wu_
Di Wu
5 months
Job Opening! . The Shapiro Lab at Caltech is looking for a Research Technician to accelerate our neuro๐Ÿง  efforts. Join us! Please RT. Apply here:
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
5 months
Congrats to Dr. @shyreeene Shirin Shivaei on defending her PhD thesis @Caltech on viral expression of #gasvesicles in T-cells and neurons in vivo -- allowing ultrasound to image previously invisible biology! ๐ŸพProud of your fearless pursuit and success!
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
6 months
The LA fires hit the Caltech community pretty hard, including my brilliant MD/PhD student George Daghlian, whose family lost their home. ๐Ÿฅน I'm glad to be able to help, and grateful to so many friends assisting however they can! ๐Ÿ’ช
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
6 months
As a huge bonus (actually main reason for coming), I got to see cool work by @jrmstrng, Bruce Drinkwater, @WoolfsonLab and others on ultrasound, tissue engineering and synbio!.
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
6 months
Finally made it to @BristolUni to pay respects to A.E. Walsby and see the building in which he worked for decades on the basic biochem and biophys of #gasvesicles! ๐Ÿ”ฌ His curiosity-driven research laid the groundwork for our GV engineering efforts. Thx @jrmstrng for inviting!
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
6 months
Just in time for ๐ŸŽ„. Using #gasvesicles as an acoustic pressure ruler! ๐Ÿ”Š๐Ÿ“ Fun collaboration with @MichaelKolios lab. Congrats Eric Strohm, @di_wu_ @torohitnayak and Dina Malounda.
@MichaelKolios
Michael Kolios
6 months
In another paper with @mikhailshapiro, we use gas vesicles to estimate very high-frequency ultrasound pressure (>80MHz), which we could not do before. We find the voltage input to the transducer at which they collapse GVs, creating "black holes." More๐Ÿ‘‡.
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
6 months
Can we make a brain tumor visible under ultrasound? ๐Ÿง  ๐Ÿ”‰ Yes, using intravenous #gasvesicles! .This can help guide brain surgery and monitor for tumor recurrence. Congrats to Claire Rabut, @GeorgeHDaghlian and collaborators!.
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
7 months
Very cool.
@JerzySzablowski
Jerzy Szablowski
7 months
qPCR can measure expression of virtually any gene. in homogenized tissues. Here, we show an "in-vivo qPCR" equivalent, where we measure a sequence-specific transcript with synthetic serum markers and enzyme-based signal amplification.
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
7 months
Awesome program run by awesome team! Deadline Feb 13.
@JacquesCarolan
Jacques Carolan
7 months
Weโ€™re kicking off the search for seed projects in our Scalable Neural Interfaces opportunity space ๐Ÿ‘€ Weโ€™re offering between ยฃ10k and ยฃ500k to researchers + entrepreneurs with bold ideas for developing tools to interface in new ways โ€“ at scale โ€“ with the human brain. ๐Ÿ‘‡(1/6).
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
7 months
5 days to apply!.
@CaltechCCE
Caltech Chemistry & Chemical Engineering
7 months
Weโ€™re looking for talented, driven graduate students to join our growing Chemical Engineering Ph.D. program at @Caltech ! . โฐ Applications are due December 1, 2024. โžก๏ธ Apply Here:
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
8 months
Thesis defense in ๐Ÿ‡ณ๐Ÿ‡ฑ is serious business. ๐ŸŽ“ Congrats to Dr. Jeremy Thalgott and advisor @LabLebrin. Fun to debate the merits of the case with Franck and @TanterM.
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
8 months
What happens when you can take videos of acoustic proteins in 3D inside the body? ๐ŸงŠ You can see things like the flow of CSF in the brain!๐Ÿง  .Congrats to Sunho Lee, co-senior author Claire Rabut, and colleagues on "Takoyaki" 3D ultrasound.๐ŸฅŸ #gasvesicles
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@mikhailshapiro
Mikhail Shapiro (same on bsky) ๐Ÿ‡บ๐Ÿ‡ฆ
8 months
Hurray to "breaking natureโ€™s monopoly on the production of extensive gene diversity" by accelerating mutagenesis 1,000,000X relative to genomes! Congrats.@chang_c_liu and colleagues ๐Ÿคฉ !.
@chang_c_liu
Chang Liu
8 months
Our work describing extensive gene divergence on laboratory timescales with upgraded OrthoRep systems is now out in @ScienceMagazine here - X thread describing the preprint is quoted below. Congratulations to @rix_gordon and team!.
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