Andrew Mikhail
@mikhaiai
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McMaster University | Integrative Neuromuscular Biology Lab
Joined November 2021
Combination treatment with antioxidants and creatine alleviates common and variant-specific mitochondrial impairments in Leber’s hereditary optic neuropathy patient-derived fibroblasts https://t.co/g0O0mT7Jev
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🚨New PhD Opportunity!! 🚨 4-yr funded PhD studentship available with myself and Professor Sarah Aldred as part of the Midlands Integrative Biosciences Training Partnership (MIBTP). See here for details of this project and others on the scheme
lnkd.in
This link will take you to a page that’s not on LinkedIn
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Perplexing results. But beautifully thorough
New! Online now: NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging https://t.co/q38CqvYl19
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Muscle fiber Myc is dispensable for muscle growth and its forced expression severely perturbs homeostasis https://t.co/jvMwFlRE9l
nature.com
Nature Communications - The transcription factor Myc stimulates growth in many cells. This study shows that Myc expression is essential in muscle stem cells to support muscle growth, but is neither...
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Neural stimulation suppresses mTORC1-mediated protein synthesis in skeletal muscle https://t.co/PHWkRfYsXM
science.org
A murine model monitoring muscle protein synthesis shows that mTORC1 is inhibited by nerve activity and fiber type specificity.
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🚨Pls Retweet/Share! 🚨15-month postdoc position available with me to investigate the dysregulation of anabolic and autophagic skeletal muscle cell signaling in obesity! Funded by @acmedsci and in collaboration with @Metabolcenter. See link for details
manmetjobs.mmu.ac.uk
All about Manchester Metropolitan - an exciting, modern university in the heart of one of the UK's great student cities.
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A map of mitochondrial biology reveals the energy landscape of the human brain Wonderful and fun collaboration with @MichelTdS and many others! @AnnaMonzel @OrianShirihai Ayelet Rosenberg was the courageous one who tackled this project, and Eugene Mosharov was the engine
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Neuromuscular junction instability with inactivity: morphological and functional changes after 10 days of bed rest in older adults https://t.co/wKa9jIHR2m
physoc.onlinelibrary.wiley.com
Abstract figure legend This figure summarises the study of neuromuscular junction (NMJ) changes in 10 older males following a 10 day bed rest period. Baseline (BR0) and post-bed rest (BR10) assessm...
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PhD defended and wrapped up! Couldn’t have asked for a better end to this (long) journey! Some of the people who made all this possible: @macgparise @mackinprof @KevinMurachPhD @mikhaiai @xhutid @steph_mattina and the twitter-less others - thank you
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Check out our latest publication where we use single-nuclei RNA-seq to study gene expression at the neuromuscular junction: https://t.co/GU9mPiMaMw The paper also characterizes three novel NMJ proteins including the transcription factor ETV4 and the MuSK-binding protein PDZRN4.
nature.com
Nature Communications - Here they use single nuclei RNA-seq to identify transcripts in skeletal muscle that maintain the neuromuscular junction, both under normal and denervated conditions, which...
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Excited to share our latest paper, out in @CellRepMed, investigating the impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Spearheaded by @CefisM & @VMarcangeli
https://t.co/WzgBnLeQg7
cell.com
Cefis et al. show that mitochondrial respiration and ROS production are not affected during healthy muscle aging but identify altered mitochondrial calcium handling as a potential key driving...
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New work from our group: Senescent myoblasts exhibit an altered exometabolome that is linked to senescence-associated secretory phenotype (SASP) signalling @AJPCellPhys #myotwitter
journals.physiology.org
Cellular senescence has been implicated in the aging-related dysfunction of satellite cells, the resident muscle stem cell population primarily responsible for the repair of muscle fibers. Despite...
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Travelled to Montreal to watch my friend & mentor Chris McGlory awarded the @csep_scpe Early Career Investigator award. Chris’ devotion to high quality science and supervision made CSEP’s choice a no-brainer IMO! (He’s also recruiting if you’re looking for an excellent lab!)
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In this recent publication in Acta Physiologica, Cefis et al evaluate whether overexpression of MFN2 in muscle counteract muscle atrophy and sarcopenia in mice: https://t.co/rCUQ8mWN2l Read also the associate editorial by @CreusAgustina and @_DavidSebast
https://t.co/5DnR8i9OYO
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Looking for a post-doc position? The LEMuR Lab is hiring! DM if you (1) have excellent English communication skills, (2) have a passion for human translational research in skeletal muscle, (3) have demonstrated leadership skills. #Myotwitter #T1D #postdoc #research
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🚨 Fully-funded 4-year PhD Studentship!! 🚨 Come and study protein metabolism in individuals with Becker Muscular Dystrophy using non-invasive methods. Supervised by myself, @Doc_Morse, @kbowdendavies, @_PaulMorgan & @christian_goede & funded by @MDUK_News
mmu.ac.uk
Find out what doctoral research scholarships are available at Manchester Met and sign up for vacancy alerts.
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The Ljubicic lab is recruiting a PhD student for the upcoming academic year. See the position details below and come join our team to do some fun science!
Fantastic PhD opportunity. Interested candidates are encouraged to reach out! #myotwitter #research #science #phd #muscle
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Please consider donating to a great cause in memory of Joan Heimbecker https://t.co/XQpnyfkNyg
gofundme.com
Hello Everyone! The Heimbecker cup is our annual charity hockey game that we ho… Amanda Johnson needs your support for 21st Annual Heimbecker Memorial Cup
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I will be advertising for another PhD student to begin working with me/the group in the coming weeks. Focus will be protein metabolism in Becker Muscular Dystrophy (funded by @MDUK_News) with a flexible start date of July or October 2024. Please contact for more info
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Happy to share another paper from my PhD that was published online today! Thank you to all collaborators for making this possible. https://t.co/h50dw2sUnG
tandfonline.com
CARM1 (coactivator associated arginine methyltransferase 1) has recently emerged as a powerful regulator of skeletal muscle biology. However, the molecular mechanisms by which the methyltransferase...
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