Merve Yigit
@mervisyigit
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PhD Student @uzh_irem. @SendoelLab dedicated to solve the alternative translation puzzle in cancer #eIF2A #cancer #stemcells #RNA #proteomics #crispr
Zurich, Switzerland
Joined October 2018
PhDone 🥳🎓 The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me during PhD!
The summer of defenses continues, huge congratulations Dr. Yigit for a superbly delivered talk and an excellent defense!
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I’m thrilled to share my very first first-author preprint and our lab’s latest work💫 Check out how we challenged eIF2A’s enigmatic role in translation and learn more about its novel role in RQC!⭐️ #RNA #ribosome #eIF2A #translation
Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x https://t.co/7nFgSou5r2
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Preprint alert 🔔 check out the latest biorxiv from my lab featuring in vivo single cell ribosome profiling in aged mouse skin! Big congrats to amazing scientist behind this hardwork @clarasdure !
How does aging alter the translational landscape of stem cells and how do these changes impact their regenerative capacity? Here we developed an in vivo single-cell ribosome profiling strategy to monitor translational landscapes of the mouse skin. 1/6 https://t.co/0QUQQx6UJI
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Final day of the Ellis and Sendoel lab retreat in epithelial biology. Excellent presentations, exciting new ideas, wrapping up with a visit to Pisa.
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It was an exciting moment to share my PhD project on eIF2A at the Cold Spring Harbor Translational Control meeting. I met great scientists from all over the world, exchanged ideas and enjoyed the great location! Thanks to all organizers! @cshlmeetings #cshltranscon @SendoelLab
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Check out @PeterFRenz3 incredible work published @Nature ! It has been a long journey and I’m so proud of him to finally have come to the end! Amazing science and amazing colleagues 🙌🏻
Clonal expansions can remodel entire tissues even when they appear normal, but what mechanisms drive this? And how do these processes differ from tumorigenesis? Out @Nature, we identify distinct TNF programs during tumor evolution. 🧵 https://t.co/S3w9Zl1NE2
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I am excited to share our new preprint. Human tumor suppressor protein Pdcd4 binds at the mRNA entry site in the 40S, where it blocks the eIF4F-independent role of eIF4A during recruitment and scanning. https://t.co/bSKFHtHWm4
#CryoEM #science #mRNA #ribosome
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Huge congratulations to Ramona for being awarded the prestigious Ernst Hadorn transitional fellowship, marking a first (and important) step towards an independent position! https://t.co/TxU75HHLZS
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The dark proteome encoded by more than 7200 annotated sORFs is redefining our understanding of the human genome. Interested in how to detect microproteins? Check out Fabiola's recent review "No country for old methods". https://t.co/ac0yZ64XSC
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Snowflakes and science at our traditional IREM retreat in the magical landscape of Sils Maria. Great discussions and a lot of fun with our invited guest from Vienna, @s__ellis.
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Publication by the Sendoel lab (@uzh_irem, @UZH_en) with first author Umesh Ghoshdastider "Exploring the pan-#cancer landscape of #posttranscriptional regulation" @CellReports
https://t.co/elvVJu6TSU
#RNA #Bioinformatics
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An honourable moment to present my poster at #EMBLprotein conference to William Merrick who started all by discovering #eIF2A nearly 50years ago, and we are still trying to find its function! Thanks to all for this meeting and exciting discussions #Sendoellab #EMBL @EMBLEvents
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Happy to share the latest pre-print from our lab. A single-cell CRISPR based investigation into clonal expansion and early tumorigenesis. https://t.co/yjKsn7o6FX A great team effort with @moorlab and @s__ellis
biorxiv.org
The tumor evolution model posits that malignant transformation is preceded by randomly distributed driver mutations in cancer genes, which cause clonal expansions in phenotypically normal tissues....
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New paper alert 🚨 Check out our newest paper to learn about how cells alter protein synthesis rate by switching between 5′UTR isoforms! Congrats to @RamonaEWeber and whole Sendoel lab 👏🏻
How do cells couple mRNA transcription and translation? By profiling different cell types of the skin we uncovered that the precise 5'UTR isoform alters the mRNA's translational efficiency by exposing or hiding 5'TOP sequences. https://t.co/y6gaK4ttTg
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How can transcription and translation be coupled? We performed long-read sequencing and found a curious switch towards TOP-motif mRNA isoforms in cancer. The presence of a TOP-motif changes mRNA translation efficiency. Thanks to the whole Sendoel lab for your team spirit!
Monitoring the 5`UTR landscape reveals 5`terminal oligopyrimidine (TOP) motif switches to drive translational efficiencies https://t.co/dZRYqRjLIJ
#bioRxiv
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📢 Open position Are you passionate about gene expression regulation and wonder how #cancer cells reprogram it? Join the Sendoel Lab @uzh_irem in Zurich as a bioinformatician and become part of a dynamic and fun team! https://t.co/0OY6isoQU8
#bioinformaticsjobs #RNA #CRISPR
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Happy #womaninscience day! @asyazgili @IpekSelcen @justZeri @lalegungordu @fabivf90 @clarasdure @RamonaEWeber @chiararick @MalloneAnna and many more!
Here they are: Some of our amazing and inspiring #WomenInScience; PhDs and Postdocs @uzh_irem. Let's celebrate your commitment to medical research on #February11 @WomenScienceDay 💯🧪. @UZH_en @UZH_Science @GraduateCampus #EqualityInScience
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Incredible work from @RamonaEWeber is on BioRxiv now! Check out how a non-canonical translation initiation factor mediates reinitiation and involved in stem cell fate by shaping the synthesis of specific signalling factors. 👇🏻
Our studies show how DAP5 mediates re-initiation on structured mRNAs. Excited to share our latest work on this peculiar facet of eukaryotic translation initiation. DAP5 enables translation re-initiation on structured messenger RNAs
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