Meg Donovan
@megldono
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Research Officer at the Queensland Spatial Biology Centre (@Qld_SBC), Wesley Research Institute, Australia. Views are my own. She/Her.
Brisbane, Australia
Joined August 2014
6/ We are excited to share this work with the community! Huge thanks to all collaborators and patients who made this possible. 💡 Check out the preprint for the full story: 👉 https://t.co/kUqyEvt9cX
#NSCLC #spatialomics @WesleyResearch @UQMedicine @pahospital @PARFoundation
researchsquare.com
While there have been therapeutic advancements in treatments for non-small cell lung cancer (NSCLC), we have a limited understanding of how the tumour composition and spatial heterogeneity influences...
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1/ After a huge team effort, we’re thrilled to share our latest study exploring the tumour microenvironment in NSCLC 🎯We integrated spatial proteomics, transcriptomics, and machine learning to uncover how the architecture and metabolism of the TME relate to patient outcomes.🧵👇
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🚨@Qld_SBC Scientific Director, @aruthak profiled in the @abcnews on the weekend! 📢 New publication led by UQ and @Yale scientists, in the leading scientific journal #NatureGenetics aims to revolutionise #lungcancer treatment. ABC article
abc.net.au
University of Queensland researcher Arutha Kulasinghe studied lung biopsies from the tumours of almost 250 patients with non-small cell lung cancer across Australia, the United States and Europe.
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We are super proud of our @YaleMed and Clinical-oMx Lab @UQ_News team for our new publication in @NatureGenet titled “Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer”. Let’s get into it… https://t.co/Bg5W7f1jf3
nature.com
Nature Genetics - This study uses spatial proteomic and spatial compartment-based whole-transcriptome profiling to develop predictive models for immunotherapy outcomes in non-small cell lung cancer.
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🚨New paper alert! 📷 We are excited to announce the publication of our latest paper, “Proximity and metabolic activity of the Tumour Microenvironment as predictors of survival in High Grade Serous Ovarian Cancer”, is now live📷 https://t.co/uNE4DJJnSZ
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Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer @NatureGenet @OncoAlert #SpatialMedicine #lungcancer #PrecisionMedicine
https://t.co/Bg5W7f1jf3
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A collaboration between TRI-based scientists from @UQ_News and @Yale is using a Google maps approach to revolutionise lung cancer treatment. https://t.co/HyzSGroCPO
https://t.co/t0cNdbvmTk
@aruthak @SpringerNature @WEHI_research @CureCancerAu @PARFoundation @WesleyResearch @NIH
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PRISM: a Python package for interactive and integrated analysis of multiplexed tissue microarrays https://t.co/GAQhzN4T4B
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Cellular keys to cancer survival/treatment resistance have been unlocked. Scientists including TRI-based @aruthak mapped the tissue microenvironment to identify immune cells linked to living longer with disease in remission. The work is in The @australian. https://t.co/tV92qHJYOj
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In a world-first discovery from the @Qld_SBC , doctors can now check hundreds of markers in a single biopsy to show which treatments, like #immunotherapy, #chemotherapy or #radiotherapy, will work best for patients with head and neck #cancer. Learn more https://t.co/jgP8RLsQ4Y
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Assoc. Prof Arutha Kulasinghe (Director of Science QSBC) and the Wesley Research Inst. dedicated team, trying to make living with Cancer a much more manageable outcome for all. It's a privilege to work along side them as the Consumer Advocate rep. Well done to the team
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🎯Metabolic patterns of resistance and sensitivity to immunotherapy in #LungCancer #NSCLC #ClinicaloMxLab @UQ_News #CellularNeighbourhoods #MetabolicNeighbourhoods @Lungfoundation @CureCancerAu #FrazerInstUq
https://t.co/CM5my4ByE5
researchsquare.com
Immune checkpoint inhibitors (ICI) have improved clinical outcomes for some patients with advanced non-small cell lung carcinoma (NSCLC), a large number remain treatment resistant. its accurate...
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🚨Excited to share our latest paper from the #ClinicaloMxLab #QSBC where we spatially resolved >580 proteins in head and neck cancer! This is the largest spatial proteomic panel currently commercially available for fresh frozen and FFPE samples 💪 https://t.co/gTRytnbzig [1/12]
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@aruthak sat down with the @AACR to talk all things spatial biology. His team at @Qld_SBC are using cutting-edge spatial biology approaches to gain deeper insights into patient biopsies and surgical resections across a range of tumour types. Read 👉
abcam.com
Arutha Kulasinghe shares the computational challenges of spatial biology, the power of AI-driven insights, and the exciting potential to democratize spatial tools.
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Members of WRI had the pleasure of attending the Art of Medicine exhibition at @gabbaart. An inspiring initiative exploring the intersection of science, art, and wellbeing in medicine. We were proud to showcase three high-resolution #spatialbiology images from @Qld_SBC
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In a feature in @NatureBiotech, @aruthak from the @Qld_SBC , discusses the future of spatial biology and the transformative spatial transcriptomics tools that are hitting the market. Read more https://t.co/tsFccaUJbW
#spatialbiology #spatialmapping #cancerresearch
nature.com
Nature Biotechnology - As the next generation of spatial transcriptomics tools hits the market, researchers are uncovering previously unknown interactions that could transform clinical research.
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A/Prof Arutha Kulasinghe @aruthak from @Qld_SBC presented his lab's latest research focused on spatial biology and immunotherapy recently at the SelectScience Cancer Research Summit 2025. Listen to his webinar 👂💻 https://t.co/BuBZyYBJVb
#spatialbiology #cancerresearch
selectscience.net
In this presentation, Dr. Arutha Kulasinghe discusses how his team uses AI and spatial biology to develop predictive biomarkers for cancer immunotherapy.
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@Qld_SBC team have presented cutting-edge #cancerresearch findings at the world’s largest #cancer #research conference in Chicago this past week, highlighting how immune cells can block the body’s response to #immunotherapy in aggressive head & neck cancers. @aruthak @megldono
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Did you see @Qld_SBC in the news yesterday? 📰 🔬 The story highlights an innovative study by researchers at WRI, who have uncovered a crucial factor that determines whether patients with head and neck cancer will respond to immunotherapy. Learn more - https://t.co/IHeh3xaHCH
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