jake
@mediocre_jake
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🇲🇾Postdoc WEHI @FelthamLab PhD @BrownLabUNSW #ubiquitin #inflammation #cholesterol 🆕️ 2024 account, past account was deleted - keen to reconnect
Joined June 2024
RT @imPeiYee: Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import
cell.com
The selective removal of mitochondria by mitophagy proceeds via multiple mechanisms and is essential for human well-being. The PINK1/Parkin and NIX/BNIP3 pathways are strongly linked to mitochondrial...
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RT @ItaiYanai: The four basic kinds of scientific papers:.1. Noise (no claim and no evidence).2. Resource (no claim but lots of data).3. Co….
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RT @KatsuFunai: What an elegant paper: intuitive yet unexpected, fiercely uncovering what many of us have suspected but clueless on how. ht….
nature.com
Nature - Mitochondria are able to maintain two competing metabolic pathways—oxidative phosphorylation and the reductive synthesis of proline and ornithine—by generating two...
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RT @Nature: Three people with severely impaired vision who received stem-cell transplants have experienced substantial improvements in thei….
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RT @Glaconde34: Getting the Numbers Right in Medicinal Chemistry - Ducho - ChemMedChem - Wiley Online Library
chemistry-europe.onlinelibrary.wiley.com
It is argued in this Perspective that not enough attention is paid to the correct representation of quantitative data in Medicinal Chemistry. In particular, results from biological assays are too...
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RT @Nature: Tools such as Rosetta and AlphaFold have redefined the protein-engineering landscape. But some problems remain out of reach — f….
nature.com
Nature - Tools such as Rosetta and AlphaFold have redefined the protein-engineering landscape. But some problems remain out of reach — for now.
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RT @MattWattUnimelb: Some important reminders for those presenting their metabolomics data. | The EMBO Journal
embopress.org
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Anyone has a clip of me in this at 1 minute I'd appreciate it!!. Thank you Malaysian INSPIRITS for making me feel so welcome especially flying from Australia .#NAMWOOHYUN #남우현 #NAMWOOHYUNINKL #NAMWOOHYUNINMY #TREEWORLDINKL #TREEWORLDINMY #INFINITE.
There alot of male fans tonight so namu acknowledge each one of them with BRO ㅋㅋㅋㅋㅋ. #NAMWOOHYUN #남우현 #NAMWOOHYUNINKL #NAMWOOHYUNINMY #TREEWORLDINKL #TREEWORLDINMY #INFINITE
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RT @nitaliya: 🌳𝐍𝐖𝐇 𝐓𝐑𝐄𝐄𝐖𝐎𝐑𝐋𝐃 𝐈𝐍 𝐊𝐋🌳. ✨FREEBIES✨. 🌱 26 Oct 2024.🌱 Like & RT.🌱 120set (Random Keyring + PC).🌱 Time & Place TBA .🌱 Dm for trad….
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RT @caitvw: Repeat after me: LAB WEBSITES MATTER!. While it may seem like a nice-to-have. in today's world, it's a need-to-have. For you,….
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RT @KRHornberger: Mechanism of degrader-targeted protein ubiquitinability. Cool structural story.
science.org
PROTAC-targeted protein ubiquitination specificity revealed by structures with cullin RING E3 ligase and E2-ubiquitin.
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RT @lydfinley: Save the date! The annual Cancer Metabolism Symposium @NYASciences will be April 8, 2025 @nyulangone featuring another grea….
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RT @ZPokladek: 📚💡 ELiAH: the atlas of E3 ligases in human tissues for targeted protein degradation with reduced off-target effect. https://….
academic.oup.com
Abstract. The development of therapeutic agents has mainly focused on designing small molecules to modulate target proteins or genes which are conventional
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RT @Daniel_C_Scott: Principles of paralog-specific degradation engaging the C-degron E3 KLHDC2, now out @SpringerNature @NatureComms .Aweso….
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RT @Glaconde34: PROTAC protein degraders to drug the undruggable enter phase 3 trials
nature.com
Nature Medicine - Pharmaceutical companies are investing in therapies that target proteins for degradation, with trials ongoing for cancer, autoimmune diseases and neurological disorders.
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RT @RapeLab: Congratulations, so well deserved! And especially proud of David Baker, the second graduate student from Randy Schekman's lab….
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RT @milicaruoft: In case you are looking for an interesting/easy reading this weekend, how about some thoughts on in vitro human cell-based….
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RT @Atulkumar_cmc: Out now We show mechanisms of specificity on two look-alike pockets of Parkin for its activator….
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