Marissa Scavuzzo
@marissascavuzzo
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hhmi hanna gray fellow @tesarlab studying glial diversity in the gut. scientific director @riseupneo . open science. equity. innovation. she/her
Cleveland, OH
Joined September 2014
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I just puked in a trashcan in the middle of an experiment with gloves on & pipette in hand without pause (7mo pregnant, not sick). So to any of you losers who think women aren't tough enough for science careers I invite you to come hold my hair back while I feed my cells
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I’m honored to receive this award and thrilled for the broad (international!) excitement about my work on glia in the gut
🎉 Congrats to Marissa Scavuzzo (
@marissascavuzzo
), one of our
#HannaGrayFellows
, who has won the 2023 Eppendorf &
@ScienceMagazine
Prize for Neurobiology for her research in how glial cells in the intestine's nervous system operate! Learn more:
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I got transfected this morning!
As a developmental biologist who has studied the negative impacts of maternal infection on offspring, getting vaccinated gives me comfort knowing our unborn babe has protection.
If you are pregnant & have q's about the vaccine, feel free to ask!
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Did I learn super resolution microscopy yesterday? Yes.
Am I in my 30s? Yes.
Did I send pictures of nuclear proteins to my (non-scientist) mom and dad today from the scope, hoping they’ll hang them on their fridge next to my niece and nephews drawings? ....Maybe..
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Thank you
@HHMINEWS
!
Words do not suffice in expressing my gratitude, so I will show my gratefulness through an unrelenting pursuit of discovery
#HannaGrayFellows
:
@MarissaScavuzzo
studies the nervous system – the one inside your gut. Her goal: to understand the many functions of glia cells in a healthy gut and then figure out how they respond to genetic, environmental, & dietary changes.
Mentor:
@TesarLab
,
@CWRU
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"who does your computational analysis?"
ME
do men get this same question when people see their data??? every single time?????
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The incredible mentors I’ve had over the years have inspired me and given me support to get where I am today; the HGF puts me in the position to be that mentor to the next generation of scientists. I'm so thankful to be part of the HHMI community and for this amazing opportunity!
Today, HHMI is proud to announce the new
#HannaGrayFellows
, 21 early career researchers who are taking on some of the biggest challenges in the life sciences.
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One of my most unreasonable pet peeves is when someone says “genes” when they mean “transcripts”
Your RNAseq is showing a change in transcript number, not a change in gene copy number.
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note: I did NOT puke in the culture room, this was during benchwork
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My first undergrad, Aakash Shah, who helped me set up so many things in the lab is now in medical school and got his white coat yesterday. He is brilliant and extremely accomplished but I am most impressed by his exemplary character. I am so proud!
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The 2023
@HHMINEWS
Hanna H Gray Retreat was magical!
I met colleagues who quickly became collaborators and friends.
So thankful for everyone in this community, especially the other HGFs, our scientific officers, and the incredible HHMI staff that organized the meeting
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What an amazing weekend at
@AAAS
/
@ScienceMagazine
in DC talking about 💩!
I am nothing without the people around me. So grateful for all of them, for the Eppendorf & Science community, and for new connections!
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First full day back at work post maternity leave so instead of staring at my daughter for ~9hrs at home I will stare at pictures of my daughter for ~9hrs in lab. Baby steps
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Have you ever wondered how food moves through our small intestine without control from the brain?
In our new preprint (link below), we found evidence of multiple functionally specialized subtypes of enteric glia with distinct molecular, morphological, & spatial identities
🧵1/7
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I don’t know what’s more surreal, seeing my face in the NYT or seeing my face between the amazing
@ValeriaMReyes
and
@zurisullivan
. I can’t believe I’m part of this group of stellar scientists!
Apply now, applications are open!
@HHMINEWS
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Omg things are so crazy in lab right now that I have pulled up a cart and a chair as “bench extensions” to have more room for samples 👩🏻🔬 🐭
My feet hurt but I’ve never been more excited about my science
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Yesterday was the official end date of my maternity leave (on paper), and I am overflowing with gratitude.
(1/15)
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We have hit the toddler stage - my daughter claws at my legs crying and screaming every morning when I try to leave for work then throws herself dramatically to the ground.
Any advice on making leaving each day less miserable (for both of us)?
@Momademia
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I can do microdissections to isolate subtypes of cells from early embryonic mice without a problem but I can’t clip my newborns fingernails without one or both of us crying
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@ivancedric_a
mTOR is a protein at the top of a signaling cascade that interacts* way too much w/proteins lower in the cascade. mTOR is shielded by proteins higher in the cascade and is inside a protective cell membrane. It stands for “man Terrorizing Other Researchers”
*harasses
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@PNgsabrina
@OpenAcademics
“What are your plans for summer break?”
“A PhD is like a regular job, there isn’t a summer break”
“Oh ok. Well, make sure you do something fun for spring break then!”
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Omg my lab mates are the BEST!!!!!
Had something today that I’m really excited/nervous about and means a lot to me, and they showed out in support when I had finished 🎉
couldn’t ask for a better lab to be a part of.
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Then: “During maternity leave I’m going to work on my paper, do some computational work, get back to painting, get a few new art pieces done, and exercise! That will feel like a win.”
Now: “I left the house today with my shirt all the way on! This feels like a win.”
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6 months into this immersive dev bio project and now Lillo the fetus can hear outside the womb, so she will be listening in to every scientific talk I attend
(i.e. don’t be alarmed if you see a headphone in my shirt, it’s just my daughter learning early)
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The Tesar lab is so awesome! Surprise baby shower today (outdoors & fully vaccinated) with fun games and treats, including baby food tasting!
They even made us a special “gender is a construct” stick to beat up a gender reveal piñata full of chocolate with 😂
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I’ve had three massive experiments fail repeatedly for the last couple of months and in the past week literally all three worked beautifully.
It’s weeks like these that make me fall in love with science over and over again! Failures make the successes that much sweeter.
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So far my best idea is hiring her as a research technician but she hasn’t mastered a fork so I’m skeptical about her pipetting skills
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Today I am doing an experiment using a new technique that I developed that nobody else in the world has yet been able to do, to look at something nobody in the world has been able to look at (or thought to look at), to hopefully/basically pioneer a new field.
Happy Tuesday! 🎉
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Four years ago I defended my PhD surrounded by friends, colleagues, and family. I had a blazer on but I was so nervous I sweat through the armpits and had to take it off afterwards. It somehow both feels like yesterday and a million years ago
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*goes into lab at 10am and leaves at 7:30pm*
“I’m going to start going in earlier so I don’t stay so late!”
*goes into lab at 7am and leave at 7:30pm*
🤦🏻♀️
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Wordle 206 1/6
🟩🟩🟩🟩🟩
OKAY great vibes for today let’s go
It’s also my birthday. Someone get me a lottery ticket
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If you’re havin cell problems, I feel bad for you, son. I got 999+ problems, but
#organoids
ain’t one.
Split me!
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This morning I woke up to the sound of my husband gently singing me love songs. But then I rolled over and saw he had his back turned to me and was singing them to Omar the cat 😒
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What an incredible cohort of scientists and humans!!!!
It is so amazing that
@HHMINEWS
is funding the rare combo of scientific excellence and healthy, inclusive labs. What a great model for us all. The future of academic science is looking better every day and I love to see it
HHMI is proud to announce our inaugural class of Freeman Hrabowski Scholars, outstanding early career faculty in science who have potential to become leaders in their research fields and to create diverse and inclusive lab environments. 1/3
#FHScholars
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My husband (
@AndrewScavuzza
) runs a science education nonprofit (
@riseupneo
) and one of the student groups proposed cockroaches as their model organism and now we have over 15 Madagascar hissing cockroaches locked in our 2y/os closet to keep them from our cats and 2y/o send help
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@HHMINEWS
Hanna Gray takeover in Cleveland yesterday!!! Was an absolute delight to have
@sofiquinodoz
at
@CWRUSOM
and to hear about the innovative work she is doing
Unintentionally matching
@KyleJCard
too… great minds think alike? 👯♀️
Photo credit
@TesarLab
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Barbie’s Dream Lab!
Barbies:
@KateLetai
@ErinFCohn
Jess Muiños
@alkaatomar
Kens:
@MayurMadhavan
@TesarLab
Ken or weird Barbie: myself
Gru + minion:
@zhan_solo
and Anushka Nikhil
Mario:
@bllclayton
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Congratulations to all the new
@HHMINEWS
#HannaGrayFellows
!!!! So excited to meet you and hear about your work.
Attention late PhDs/early postdocs! The 2023 application is now open - go to the website to apply for this life changing program 🤗
Meet the 2022
#HannaGrayFellows
!
These talented postdoctoral scientists represent a promising and more diverse future for biomedical science.
Learn more about them at
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Two awesome packages came this week - loving the stylish new backpacks!
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“Quick trip to the zoo before heading into lab” has turned into being locked in the primate exhibit while the zoo tries to capture an escaped wolf running around on the loose 😳
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When it’s Friday night and you got places to be but you also have code to run and data to see
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Heading home from my first in-person
@HHMINEWS
meeting feeling motivated and full of inspiration. So grateful for the organizers for putting together such a stimulating meeting and to finally meet some HGF in real life. What a fantastic community!
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Congratulations to all the new
#GilliamFellows
, excited to hear about all the amazing work you do!
Really pumped to see
@CastrillonJess
among the cohort representing
@CWRUSOM
in the
@HHMINEWS
community 🎉
#clevelandrocks
Today HHMI announces our largest group of new
#GilliamFellows
as part of our commitment to advance diversity and inclusion in science. Learn more and meet the Fellows:
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“The entire scientific community benefits when diverse perspectives come together to tackle the most pressing challenges of our time”
If you feel like an outsider, come from a different background, or see the world differently, this program is for you!
APPLY!
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Applications for the 2024
#HannaGrayFellows
Program are now open!
At HHMI, we believe in 'People, not projects.' Join the Hanna Gray Fellows Program and be part of a community where every scientist's journey and contribution matters.
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4 days, 4 nights, and 4 months pregnant backpacking through the mountains in the desert with my BFF (who carried all the heavy stuff, my deceiving backpack was full of sleeping bags) 🌵
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Have a full Saturday of important experiments in the lab and of course nothing has worked
BUT
I just realized that I am due to give birth next week which means next time this happens I can do my favorite post experimental failure tradition and enjoy a glass of bourbon 👩🔬😭🥃
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I'm sick of being told that I don't matter as much, I have less value, I'm not as important. Whether it is in large moves like today or in small (potentially subconscious) actions, it happens every. single. day.
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Rnase Rnase go away
Come again some other day
We want to profile our cells okay
Don’t destroy my RNA
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For my birthday my husband got my first 3D confocal image (upper embryonic mouse GI tract immunostained) custom printed onto two canvases 😭 best spouse ever
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If you are a graduate student nearing your defense or an early stage postdoc you should apply! Up to 8 years of funding!
Reminder that applications for the Hanna H. Gray Fellows Program are due by December 1, 2021. Learn more:
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How am I able to grow and culture miniature human organs out of stem cells, yet I can’t even keep an already grown succulent alive??
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It’s that time of the year again! Time to break out my award winning Ugly Christmas Sweater (my all time ugliest blot)
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Had such a wonderful time visiting
@UCLA_BRI
. Thank you to the organizers of the SYNCS series for the invitation to share my work and for the opportunity to meet with so many leaders in the field!
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My lab mates are the best ❤️
@kevbot1992
@ErinFCohn
@bllclayton
@zhan_solo
@WWulftange
@ArturGev97
Elizabeth and Yuka
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My essay “The way you move” is out now in
@ScienceMagazine
! Link below ⬇️
(Title inspired by
@Outkast
)
🎉 Congrats to
@marissascavuzzo
, winner of the 2023 Eppendorf & Science Prize for Neurobiology for research revealing how specialized glial cells embedded within the walls of the gut, which operate independently of the brain, fine-tune intestinal function.
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It’s the International Day of Women and Girls in Science! To celebrate, I’m doing science all day 🤦🏻♀️
There are so many stellar women scientists, here are a couple of them to follow and watch out for 🧵:
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I just spent twenty minutes googling “dark freckles on newborns face” worrying about sun exposure to then wipe the freckles and realize they weren’t freckles, they were coffee spots. I spilled iced coffee on her.
🤦🏻♀️
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We
@TesarLab
are excited to be selected as a host lab for the
@SimonsFdn
@SFARIorg
SURFiN Program!
ATTENTION: Undergrad students in the Cleveland area from historically excluded groups (including women): apply to join our lab studying glia in ASD
Please RT/help spread the word
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My graduation gift to my advisor was a painting of a light sheet image I took, but with the nucleotide sequence of the targets
Alexa Fluor 555 is mucin, 488 is insulin1, 405 is amylase
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My parents grew up in low income houses and worked crazy hours to give their kids a different financial situation than they had. When I was young my mom would say she wanted me to be an orthodontist-a stable low stress job with high pay & regular hours. So anyways, I’m a postdoc
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Anyone who is thinking of applying - if you want advice feel free to reach out!
Applications are OPEN through December 1, 2021 for the next round of the
#HannaGrayFellows
Program. Learn more and please spread the word! More info here:
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Don’t you hate when you forget the English word for something? It keeps happening to me, maybe lack of sleep. Worst part is I only speak English
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Ugh dealing with an OBNOXIOUSLY good differentiation… it’s going to take me 400 years to split all of these monsters!!!! Currently going from 1 to 15, they all look beautiful so no man left behind. Been an hour and only a fraction done.
..that data gonna look good tho 🙊 👀
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@PsychedSN
@emmafriedmann
Someone I went to grad school with was in the clinical trials and got Pfizer, two months later she got pregnant with triplets 😅 (all born now and healthy)
maybe the vaccine impregnates people
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We strongly believe in open science and the power of review - we really appreciate all feedback and suggestions to make our conclusions stronger!
DM me here or send an email with critiques & suggestions: marissa.scavuzzo
@case
.edu
Link ->
🧵/end
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My lab is awesome - congrats to everyone involved in the project!
Essentially they cured a mouse with a rare disease.
Next step, humans.
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a lot of successful PIs forget the names of new lab members or even people who have been in their lab for years... my successful PI knows the name of every lab member, spouse, significant other, their children, and their pets. Be like my PI
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My PI is awesome!!! Dropped of oligodendrocyte holiday oreos for everyone around in the lab ☺️
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Accidental matching with my awesome undergrad!
Now if only I could match her organoid plating skills.. she picked it up on the first try! 👯♀️
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I signed up for a 100 mile relay with some friends (my leg is ~13mi) but then got busy and haven’t ran in months. I have the Lord of the Rings soundtrack queued up, if Frodo could make it to Mordor on those tiny hobbit legs then my drumsticks will make it to the finish line
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Growing a fetus:
< 36 weeks and 2 days:
I don’t get why people are so dramatic, this is pretty easy
> 36 weeks and 3 days:
Death lies on me like an untimely frost;
O proud death,
What feast is toward in thine eternal cell
Here I lie in cold obstruction and rot
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Thankful to have the opportunity to hear about all the amazing work at the
@HHMINEWS
Cell and Developmental Biology meeting, and also very thankful for
@angiescav
who watched my sweet 6wk old so I could focus on the science (photo credit to her/ 🥛 time)
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I’ve been following Gastronauts for a few years and it’s an honor to now officially be part of the gang
What an innovative and inclusive group of gut-brain scientists! Blown away by the work being done in & out of the lab. Thank you
@gutbrainmatters
for building this community
Incredible experience at
@DukeU
. Thanks a lot
@Gutbrainmatters
for inviting us to speak at this year's Gastronauts Bite Size Summit!
@chio_servin
@marissascavuzzo
@ScienceStowers
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It was an honor to address the 2019
@bcmhouston
graduates this week in Houston. Best wishes to everyone in their future endeavors!
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Had a fun morning with
@riseupneo
holding a free community science event. These kids are our future and it sure is looking bright! 🌞
So grateful for
@harborandbridge
for hosting us and all the Rise Up Teaching Fellows who did an amazing job guiding kids in experiments.
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Got this email this morning 😂 I forgot that I applied to the astronaut training program as a backup plan to securing a tenure-track faculty position at a med school or research institute
My backup plan says a lot about the academic job market 😬
#givemealabortakemetothemoon
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I am holding my screaming naked 1yo while my temporarily disabled husband fishes her poop out of the tub (while we all have the flu), but I cant stop thinking about how grateful I am.
@KateLetai
you are an actual research angel who came to my rescue and saved my mouse work 1/2
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@TesarLab
wins the Landis Award for outstanding mentorship!
I couldn't think of anyone who embodies what this award represents better. So glad to call the lab home for my postdoc!
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Got my negative rapid test result, masked up, and headed to Montauk!
Will be the first time I’ve ever left these two and longest time away from my baby, but I couldn’t miss the opportunity to soak in all the groundbreaking research going on at the
@nyscf
innovator retreat
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Presented at my last
@nyscf
innovators retreat today as a Druckenmiller Fellow, such an honor to be a part of such a remarkable community and so thankful for their support!
Can’t wait to crash the in person retreat next year as an alumni 😝
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Excited to share that I am now officially a New York Stem Cell Foundation - Druckenmiller Fellow! I am grateful to have the opportunity to be a part of this great community.
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trying to have serious data conversations with
@ArturGev97
via Zoom and get work done on a Friday evening while Omar the 30lb monster cat who takes residence in our home is in full weekend mode
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#IntestinalOrganoids
@cphbioconf
has been a scientific utopia. A treat to be here in Favrholm to hear about all the cutting edge work by the leading labs in this field and to gain feedback and advice on my own (very early) work in this arena.
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Anyone who says
#womeninscience
don’t face more challenges has obviously never done a dozen mouse intestinal dissections in one sitting during their first trimester 🤢
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Disappointed I can’t handle our Halloween candy this year! No, not because of COVID, we’re launching candy at kids from the front porch to the sidewalk using tongs. Because I’m a bucket of fried chicken and buckets of fried chicken don’t have arms
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My mentor is the best, always a champion for underrepresented individuals in science!
A screenshot of the email that I sent to
@NatureComms
EIC
@elisader
is below. I hope it inspires others to do the same.
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I have a great writing regimen to share. First, map out your ideas by pen & paper. Next, quickly eat your body weight in food. Follow this by drinking 2 carafes of spiked coffee. Sulk for 1hr, then take 100 photos of your pet. From 2am to 7am your writing will flourish. Enjoy!
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