Marco_Trizzino Lab
@marcotrizzino
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Associate Professor at Imperial College London. Developmental and Evolutionary Genomics. iPSCs, chromatin, TEs. Craniofacial and Neurodevelopment
London, UK
Joined July 2013
The paper is now published on @AJHGNews! Again, this was a huge effort from brilliant PhD student (now Dr. !) @SamBarnada, in collaboration with many, and especially with essential contribution from @LabEHerrera. https://t.co/YxQuzhA66G
New preprint from my lab! Led by superstar PhD student @SamBarnada in collaboration with @LabEHerrera and many others including @BrugmannLab, Kevin Peterson, Steve McMahon. We investigated the role of ARID1A (BAF) in neural crest cell specification (1/n) https://t.co/4sKzeqIZyr
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New PhD position with us and @EastbioDTP is now open, focused on developing novel iPSC- organoid models 👇👇👇
findaphd.com
PhD Project - EASTBIO Establishing and characterising a novel neuroimmune iPSC-organoid model at University of Edinburgh, listed on FindAPhD.com
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A human forebrain organoid model phenocopies dysregulated RNA and protein homeostasis in ALS/FTD-associated TDP-43 proteinopathies
biorxiv.org
Background TAR DNA-binding protein 43 ( TDP-43) proteinopathy is a central hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), yet current experimental models fail to...
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Se al Louvre avessero esposto queste immagini di Michael Jordan in 4K, i ladri avrebbero rubato queste e non i gioielli di Napoleone. Ipnotico. Iconico. Incredibile. Unico. https://t.co/brzCGWx84g
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I have been living in the UK for several years, and still can't wrap my head around the fact that half the country calls lunch "dinner" and dinner "tea", while the other half of the country calls lunch "lunch" and dinner "dinner" but school lunches are still called school dinners
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One month remaining for early-career researchers to apply for a funded place at our Workshop 'Novelty, Co-option and Divergence During Gene Network Evolution' organised by James Hombría & Antónia Monteiro @MonteiroLab. Deadline 5 Dec. https://t.co/huSYpJdw6O
#BiologistsWorkshops
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1/ Excited to share our new study with @Brumbaugh_JB, now out in @NatureBiotech! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 https://t.co/D7fnkJgNQ6
nature.com
Nature Biotechnology - Stem cell differentiation is controlled by manipulating RNA condensates.
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Nobel Price for Peace… of shit
Donald Trump just posted an AI video of himself dumping shit on protesters from a “King Trump” jet.
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We have a fully funded PhD to study mosquito vision — combining single-cell genomics, evolutionary genomics & high-resolution imaging. Discover how these tiny hunters see the world. RP, apply and contact me if interested!
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Stem cells strike again: Promising results from a new Parkinson’s trial just published in the journal Cell. Dopaminergic progenitors are early-stage brain cells that can mature into dopamine producing neurons. These are some but not all of the cells (and circuits) lost in
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📢 Our newest episode is out! Daylon and Arun chat with Dr. Carole LaBonne (@labonnelab) from @NorthwesternU about her work understanding the genesis of #NeuralCrest stem cells at the level of signaling pathways and transcription factors. 🎧 Listen now: https://t.co/lWRZf7Z7wJ
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Omics showed the power of profiling many genes side by side. Same logic applies here: characterizing multiple disease models in parallel gives more precise insights. Single cell comparative organoidomics of neurodevelopmental disorders is a very promising strategy!
New preprint showing human brain organoids from our library of patient #IPSCs modeling neurodevelopmental disorders. Four major clinical classes of NDDs (MIC, EPI, PMG, ID) showed distinct scRNAseq and organoid phenotypes. https://t.co/uMlxxGmo0O
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Interested in joining my lab to study the evolution and development of monoaminergic neurons? You can now apply for the Giuseppe Levi Post-Doc Fellowship (2 years, Neurobiology, EU citizens). Deadline: 10 Nov 2025 – 18:00 For more info https://t.co/72ofdum091 and email me!
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Always the same speakers…
Don't forget to register for the upcoming Keystone Symposium Epigenetics & Gene Regulation in Health and Disease (Geveva, March 03-06). Join us for fun discussions on chromatin mechanisms with therapeutic innovation!
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Our latest: combining single-cell RNA-seq from 16 species and HCR validation, we show that monoaminergic neurons share a conserved transcriptional identity across Bilateria. In contrast, we find no evidence for this program in non-bilaterian metazoans.
biorxiv.org
The evolutionary conservation of cell types over deep time has long been theorised but remains difficult to demonstrate. Monoaminergic neurons, which produce molecules such as serotonin and dopamine,...
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True. There is no iPSCs without Gurdon’s nuclear reprogramming
Also to stress the importance of fudamental curiosity driven science - his #devbio work served as the foundation for much of stem cell biology and regenerative medicine
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Also to stress the importance of fudamental curiosity driven science - his #devbio work served as the foundation for much of stem cell biology and regenerative medicine
John Gurdon https://t.co/QXMjHLKlS3, beacon of a generation that tackled head on the deepest question of biology: the development of an organism. The best tribute to him and his peers should be to remember and follow the path they forged for how to do Science in form and content.
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Applications are now open for MRes + PhD studentships in interdisciplinary health science @imperial_mrcdtp commencing Oct 2026, generously funded by @The_MRC. https://t.co/RHBCrhitk2
#MultiSci #MRes #Studentships #London #Interdisciplianry #Sciencephd
findaphd.com
Apply for a PhD: Imperial College London MRC DTP (PhD) Studentships in Interdisciplinary Health Science (MultiSci) at Imperial College London
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📢 📢Delighted to announce our latest pre-print co-led by our fantastic and talented postdocs @IreneFaravelli and @bolanosAnton 👩🏻🔬👩🏼🔬💪! Human cortical organoids record developmental time for 5 years in vitro. 🧫🧠⏳. A huge collaborative effort, big thanks to all co-authors! 🧵👇
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Many enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells. In a new preprint, we share some clues about when, how, and why this happens! https://t.co/LqoCnya3hH
biorxiv.org
In primed human pluripotent stem cells (hPSCs) resembling post-implantation epiblast, numerous lineage-specific enhancers assume the poised chromatin state, co-marked by H3K4me1 and Polycomb-associ...
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