My perpetual state of mind. from - @PDLComics

This week in MathOnco: evolutionary double-bind, MRI math models, pharmacometric models, and more... Artwork (Simon Fay) is based on @luddyka & I's recent RED paper. Read it & subscribe, here: https://t.co/bX7KEuiZ43

How do mRNA vaccines help fight cancer? A @nature publication today tells the story, one with big implications, as reviewed here @MDAndersonNews @StevenLin_MDPhD @adam_grippin https://t.co/J0OvNP1Oc4

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi have been awarded the 2025 Nobel Prize in Physiology or Medicine for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body. The Nobel Prize laureates

Our immune system is an evolutionary masterpiece. Every day it protects us from the thousands of different viruses, bacteria and other microbes that attempt to invade our bodies. Without a functioning immune system, we would not survive. One of the immune system’s marvels is its

📢We're #hiring Group Leaders! Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning. 🔹5-year renewable appointment 🔹Pioneer new tools & approaches 🔹Collaborate across disciplines Apply by Nov. 4👉 https://t.co/oNKFiNXDtC

💉 Checkpoint inhibitors help many melanoma patients, but not all respond. A study finds that TGF-β activity isn’t a reliable predictor, highlighting the complexity of immune resistance. 🧬🛡️ Read the full article here 🔗 https://t.co/5Ef9IdCPCP

Irvine and colleagues suggest that targeting IL-12 and IL-15 to CD45 is an effective antitumor treatment and limits adverse effects associated with cytokine therapies. Read it here: https://t.co/Xi3kNqYXyH https://t.co/jYp55CFGsc

The role of glycans in human immunity—a sweet code: a comprehensive review about the role of glycans in the immune response. https://t.co/Hz1NRzc3Zt #glycotime

Editorial @luddyka: extending the functional lifespan of NK cells: towards durable cytotoxicity in NK-cell based immunotherapy https://t.co/jvw2cLlP1X on https://t.co/Irs0seUujq

This announcement from the NIH is fantastic “NIH will no longer seek proposals exclusively for animal models” All new proposals should include modern alternatives: e.g. computational modeling and organoid style technologies w human components @mathonco https://t.co/LzX9ypljwn

Fascinating science chats in Today's lab meeting discussing Bob's recent paper written with @jillagal @HemachanderTBio and others. "On the Origin of Information Dynamics in Early Life" https://t.co/H3r0f4qfdi

#SpatialOmics The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs 15 M cells 100 donors 10 organs Liver Pancreas Bone marrow Lymph node PBMC Prostate Stomach ILeum Colon Appendix CosMX 1k 6k WTA Xenium GeoMx RNAscope

https://t.co/hsEnE1rrBy

Wishing a very Happy Retirement to Geri Rodriguez. The heart and laughter of our crew for over 15 years!!! @MoffittNews

Save the date #MathOnco25! October 29th-31st in Tampa, Florida. Directly before the 13th @imoworkshop (November 3rd-7th) - stay the weekend and brainstorm the beaches! More information to follow but @EvolTherapy will be a key theme @mathonco @MoffittNews

Sara Soliman: highlights the difference between Resistance and Persistence

Day one of an exciting workshop "Cancer Dormancy and Therapy Resistance"

Are you interested in joining the only mathematical oncology department @mathonco in a cancer center @MoffittNews in the world? We have an open rank tenure track position (assistant/associate/full) available now and would love to hear from you! Apply here: https://t.co/5EuJ24XJ0E

This underscores the complexity of the innate immune system, which remains a black box. Unlike the adaptive immune system, where some mechanisms are well understood, we have little insight into how the innate system operates, integrates signals, or interprets them. #immunology

✍️Submissions are invited for the special issue on computational models in cancer immunotherapy of @Cells_MDPI journal https://t.co/EkttvD4T2a Deadline: March 31 2025