Steven Zhao
@SteZhao
Followers
798
Following
2K
Media
202
Statuses
2K
#Rheumatology clinical lecturer, University of Manchester
Joined November 2014
RT @RheumatologyUK: 📢 We are delighted to share our newly-updated clinical guideline for the management of axial spondyloarthritis! Read mo….
0
14
0
RT @DrAiLynTan: 📢Do you work in #Rheumatology or #Dermatology in the UK?. Please help us understand the impact of #obesity on #psoriasis an….
0
3
0
RT @MariosGeorgakis: A great new resource for phenome-wide genetic explorations by the Estonian Biobank🇪🇪🧬. 👉206,159 participants.👉GWASs fo….
0
12
0
RT @MariosGeorgakis: A GWAS meta-analysis for sarcoidosis in 9,755 cases and 1,526,867 controls🧬. In diseases like sarcoidosis, where we kn….
0
4
0
RT @DrAiLynTan: #PhysicalActivity for those with chronic widespread pain & #fibromyalgia effective in. ✅Reducing #pain & #depression.✅Enhan….
0
10
0
*these results replicate an earlier candidate gene study of TYK2 and sarcoid
0
0
1
The largest #GWAS of #sarcoidosis to date identifies 28 susceptibility loci and implicates CCDC88 and #TYK2* genes. MR suggested causal roles of IL-23R and IL-2Rβ, and risk increasing role of #BMI. @Yuan_AS .
nature.com
Nature Communications - Sarcoidosis is an inflammatory disease with a strong genetic component. Here, the authors use GWAS to identify 28 loci associated with sarcoidosis and perform downstream...
1
0
6
This study compares #apremilast and #methotrexate (that have more similar efficacy for cutaneous psoriasis) to see if targeted therapy reduces PsA risk independent of skin control.
0
0
0
However, a key limitation is that IL-17/-23 inhibitors have superior efficacy for controlling cutaneous disease, the severity of which is an independent risk factor for PsA onset.
1
0
0
Choice of psoriasis therapy can influence PsA risk, e.g., drugs targeting the IL-17/IL-23 pathway reduces risk of PsA compared to TNF inhibitors.
1
0
0
Most PsA cases occur in those with cutaneous psoriasis, which presents a unique opportunity for early detection or even prevention of PsA.
1
0
0
🚨#Apremilast (#Otezla) is associated with⬇️risk of #PsoriaticArthritis compared to #methotrexate among people with cutaneous #psoraisis (HR 0.85, 95%CI 0.79, 0.91). Research funded by @PsoriasisInfo .
1
0
1
🚨The incidence of #uveitis and #IBD in psoriatic disease, and vice versa, is not well described. This study shows, among other things, that uveitis and IBD incidences are higher in #PsA than cutaneous-only #psoriasis and higher in females than males.
1
1
8
🚨#Tofacitinib ⬆️ #cardiovascular & #cancer risk in RA. But how relevant is this risk to people with #AxialSpondyloarthritis or #PsoriaticArthritis?. This study did not find⬆️risk of JAK compared to TNF/IL17 inhibitors in SpA. Funded by @PsoriasisInfo
0
6
10
RT @MariosGeorgakis: Mendelian randomization (MR) has been criticized due to a flood of papers based on the output of a single R command.….
0
25
0
RT @UoMMskResearch: 🚨 Fully funded PhD opportunity! 🚨. Join the DigiRA project at the University of Manchester & improve adherence in RA!….
findaphd.com
PhD Project - (Bicentenary) Development of a prototype digital platform to improve patient adherence in rheumatoid arthritis: DigiRA at The University of Manchester, listed on FindAPhD.com
0
1
0
RT @RheumatologyUK: BSR guidelines on biologic DMARDs will guide clinicians to provide the safest, most effective care for inflammatory art….
0
4
0
RT @RheumatologyUK: 🔈 Guideline consultation is open and we want to hear from you!. 💭 Review our draft guidelines for axial spondyloarthrit….
0
2
0
RT @artschuermans: What does the circulating proteome teach us about common heart diseases?. Thrilled to share our analysis identifying new….
0
36
0