TILs Working Group
@TILsWorkGroup
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We are interested in the immune infiltrate in Breast cancer and what it means for treatment and prevention.
All over the world
Joined December 2017
We've recently launched a global survey on the potential use of #TILs for future trial designs and use in daily practice. We would love to hear what you have to say 👇 https://t.co/RaEvMXuSYb
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Such a privilege to be part of the international TIL Working Group @TILsWorkGroup and to collaborate with Dr. Salgado on NeoTIL. #SABCS @muschollings @stolaney1 @OncBrothers @LoiSher
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Thank you to the International Working Group on #TILs in #breastcancer and all collaborators for their work in the #APHINITY #TILs exploratory analysis and in advancing #breastcancerresearch. Listen to an important message from Dr. Roberto Salgado as #SABCS25 draws to a close.
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Amazing presentation by Roberto Salgado from @TILsWorkGroup TIL assessment of APHINITY using CASE45 AI model and manual TILs (great ICC) Combining AI and manual assessment is a better prognostic biomarker than either one of them
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TILs matter in HER2+ BC! In ShortHER trial, mapping their spatial organization with AI assessing: 🔹Immune-tumor interaction 🔹Aggregates/TLS (Hotspots) further refines prognosis beyond manual evaluation PS2-08-11 at #Sabcs25 @UniPadova @iov_irccs @TILsWorkGroup
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Tagging @TILsWorkGroup to amplify this great work
✨✨hot off the press from the #loilab. We show here that pregnancy & breastfeeding is associated with increased T cells in the normal breast and protection against #tnbc #breastcancer moving the role of immunity from treatment to prevention. 👏👏Thanks to @FAndreMD @DrChoueiri
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✨✨hot off the press from the #loilab. We show here that pregnancy & breastfeeding is associated with increased T cells in the normal breast and protection against #tnbc #breastcancer moving the role of immunity from treatment to prevention. 👏👏Thanks to @FAndreMD @DrChoueiri
Translational data shows that #breastfeeding helps personal immunity improving CD8+ T This work can help to understand better the immune system and breastfeeding mechanisms @LoiSher @OncoAlert #ESMO25 @FernandoOnco
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The EU-funded MSCA Doctoral Network “Spatial Crosstalk in Immune-Oncology” (SpaXio) is now officially recruiting 14 PhD students to decipher the metastasis-promoting microenvironment of colon and breast cancer. More info here:
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😎if #TIL had been the prespecified biomarker, pembrolizumab might well be approved for this indication. PD-L1 IHC has real technical limitations- patients deserve multiple validated ways to identified immune enriched tumors. #TILs are simple, free & readily available- wait 🤔is
💫🌟Association of potential biomarkers with clinical outcomes in metastatic TNBC treated with pembrolizumab or chemotherapy 👉 https://t.co/NomK14VXl4
@JavierCortesMD @ProfAnthoG @ASCOPres @Prof_Nadia_H @LoiSher 🧬 KEYNOTE-119 exploratory biomarker analysis 🔹 TILs ≥5% → ↑
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Study across 45 institutions shows AI validity in TIL quantification for melanoma. Reproducible with prognostic validity and open-source. @tznaung 👉 https://t.co/CprLGJYH80
#AIinPathology #Melanoma #ComputationalPathology
jamanetwork.com
This prognostic study compares the analytical and clinical validity of a machine learning algorithm with traditional pathologist-read methods for quantification of tumor-infiltrating lymphocytes in...
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Some studies shows how we can reduce costs based on biomarkers SHORT-HER 9 weeks of trastuzumab is ✅ based TILS 20% or more @TILsWorkGroup @OncoAlert #oncoalertAF @JAMAOnc⤵️
jamanetwork.com
This 10-year follow-up analysis of the ShortHER randomized clinical trial evaluates the association of tumor-infiltrating lymphocytes with distant disease-free and overall survival among patients...
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📄 Pitfalls in ML-based TIL assessment 🔗 https://t.co/qpf9qZ1zbt 📄 Spatial analyses of immune infiltration in cancer 🔗 https://t.co/8HlHlVhla9
#ImmunoOncology #DigitalPathology #TILs
pathsocjournals.onlinelibrary.wiley.com
Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However,...
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🎉 Thrilled to share that 2 @JPathol papers from the TILs Working Group ranked in the Top 10% most-viewed in 2023! 👏 Huge thanks to all collaborators, @JPathol & our readers for your support. 📎 Links in comments ⬇️ #TopViewedArticle #TILsinBreastCancer #pathology
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Great slide highlighting not only are TILs predictive of pCR...it also translates to being prognostic beyond pCR for good outcome and DFS. Seems like we have a LOT of data on TILs now, why aren't they standardly provided on path reports???🧐 #SABCS24
@SABCSSanAntonio
@OncoAlert
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🤩🍾10th anniversary TILs-Working Group at @SABCSSanAntonio 2024 - everyone welcome! RSVP here: https://t.co/xMkVqwGYr7
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The largest TILs-Workshop done so far! More than 100 pathologist, residents in training and medical students learning how to score TILs. Organized by the Narayana Medical College, India. Who follows? 💪🏼
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Join us for the 2024 Peter Mac Breast Cancer Medical Oncology Education Day! 📅 On Friday, 11th October, dive into the latest in breast cancer care with experts at Peter Mac or via Zoom. Registrations: https://t.co/3OihTUlqSt
@PeterMacRes @PeterMacCC
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Towards targeting the breast cancer immune microenvironment
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