Kousik Kundu
@kousikbioinfo
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Associate Principal Scientist at CGR, @AstraZeneca | Interested in genomics of human complex traits | Formally @Cambridge_Uni and @UniFreiburg | Views my own
Cambridge, England
Joined January 2012
Thrilled to share our work on fine-mapping of immune-mediated diseases (IMD) using regulatory quantitative trait loci (QTLs) finally out in @NatureGenet
https://t.co/t0piCoGOxl
@SoranzoTeam @sangerinstitute @Cambridge_Uni
#immunediseases #autoimmune #GWAS #QTL 🧵 1/14
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📢 new preprint alert: So so excited to share our analysis on the impact of common and rare variants on single-cell gene expression in blood, using WGS and scRNA-seq data from nearly 2,000 individuals and 5.4m cells as part of TenK10K phase 1 🧬 https://t.co/pOb86zbfDd 🧵👇 (1/n)
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Excited to share our "mastzellen" paper! Mast read! How primitive is this mode of immune regulation by cell-intrinsic immunosteroids? 🤔 Well done Jhuma P. and Qiuchen Z., et al. 👏👏 👇 https://t.co/VSZ0XMCZIX
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AstraZeneca's Centre for Genomics Research is hiring! Check it out if you are interested in leading an exceptional team of scientists who apply innovative machine learning approaches to large scale genomic and multi-omic data for drug discovery. https://t.co/sJoM9GVaOk
lnkd.in
This link will take you to a page that’s not on LinkedIn
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Check this cool work done by @C_Glastonbury and colleagues using @uk_biobank #MRI and #MachineLearning on #heart function #Genetics!
In absolutely perfect timing for #ASHG24 I am so pleased to announce the labs second manuscript that was entirely conducted @humantechnopole. Here we showcase the power of diffusion autoencoders for phenotyping time resolved cardiac MRIs in 70k subjects. https://t.co/ep4J6CkNkq
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#ASHG2024 folks, check out the presentations from the Center for Genomics Research @AstraZeneca.
Thrilled to be in Denver with 14 colleagues from @AstraZeneca’s Centre for Genomics Research, ready for 5 days of human genomics #ASHG24 The perfect chance to learn about how genomics is transforming drug discovery! Here’s a thread of our presentations - see you there 😀
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To those at #ASHG24, check out these presentations from our lab: @KlaudiaMWalter will be talking about rare variant associations and founder effects in British South Asians from @GenesHealth at 1.45pm on Friday (Session 81). 1/2
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Interested in B cell biology, immunogenomics and autoimmunity? We are looking for an enthusiastic postdoc in my lab @humantechnopole. Join us for a 4 years fully funded postdoc position. Outstanding scientific environment and infrastructure! Apply until 14 October 2024!
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In our latest work, we explore the contribution of rare, typically inherited, damaging genetic variants to the risk of severe developmental disorders (DDs) and establish a major role for incompletely penetrant rare variation. Now out on medRxiv: https://t.co/NnB3bUr8bS
medrxiv.org
While the role of de novo and recessively-inherited coding variation in risk for rare developmental disorders (DDs) has been well established, the contribution of damaging variation dominantly-inhe...
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Answers to the puzzle of aging lie partly in our telomeres. Out yesterday in @NatureGenet, the latest study led by @AstraZeneca's Centre for Genomics Research used @uk_biobank #genomics data to ask why some people have longer telomeres than others. https://t.co/ZMH4pxIsKc 🧵
nature.com
Nature Genetics - Genome-wide association analysis of an improved telomere length score, calculated from quantitative PCR and whole-genome sequencing measurements in 462,666 individuals in the UK...
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RT this amazing opportunity to join two fantastic groups
We are hiring!!! @BlagojeSoskic and I are looking for a postdoc in RNA biology of B cells!
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Our #sepsis #eqtl paper is now published! Thank you @CellGenomics and our reviewers for a swift and smooth publication process
cell.com
Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Burnham et al. mapped genetic variants associated with differential gene regulation during sepsis and, from...
Sepsis is a highly heterogeneous condition resulting from the dysregulated host response to infection. Here we report our latest work with @KnightGenetics led by Katie Burnham. #sepsis #eqtl
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Recently out on #bioRxiv: our updated approach to identify regional variability in missense mutation intolerance (“constraint”) in protein-coding genes using the gnomAD database (@gnomad_project). 1/n https://t.co/96f1EbwWDj
biorxiv.org
Missense variants can have a range of functional impacts depending on factors such as the specific amino acid substitution and location within the gene. To interpret their deleteriousness, studies...
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Come work with us at @PREDICTIBD! @KristineAllin and I are looking for a PhD student to combine the incredible Danish healthcare registry data with genomics. Great collaborators in UK, US, Nordics. Lovely industrial partners. It's time to personalise IBD care. 1/3
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Two Postdoc positions in my lab @humantechnopole! Please RT! We have an @OpenTargets project in collaboration with @GosiaTrynka lab. An ambitious project, with industry partnership to comprehensively understand regulators of B cell activation using CRISPR screens.
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Congratulations to my student @tenghiangh on her first PhD preprint! It's about recessive associations in @GenesHealth , a cohort of >40k British South Asians. See her thread for an account and the paper here https://t.co/tRadSYboVV.
medrxiv.org
Genetic association studies have focused on testing additive models in cohorts with European ancestry. Little is known about recessive effects on common diseases, specifically for non-European...
When we think of recessive conditions, rare monogenic disorders come to mind. Yet variants have recessive effects on common diseases too! We profiled the single-variant recessive landscape of a cohort of 44k British South Asians, now live on medRxiv: (1/11)
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Excited to see our GWAS meta-analysis of NMR metabolic biomarkers in 136,000 participants from 33 datasets out in Nature https://t.co/36AhT8Zfqf after years of work by many people, esp. @savitakartik @ClareOliverWil1 @eliasallara @mak_sysepi @johanneskettune & Minna Karjalainen
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AB-OpenLab is hiring!! First advertisement is out here https://t.co/qgZoSO7oAI Looking for individuals with passion for web technologies and game development. More positions for projects in Evolutionary biology, Machine Learning and AMR will be advertised soon. Please RT!
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Excited to share @AllofUsResearch program’s flagship genomics paper describing 245,388 clinical-grade genome sequences encompassing >1 billion genetic variants published today in @Nature
https://t.co/ph5Cd2Tq6I
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Very excited to have our study, the largest ever genetic investigation of circulating retinol now online at @NatureComms. We found evidence for novel biology and use these data to refine our understanding of retinol/retinoids on human health. 1/2 https://t.co/VYYi5Kgar0
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