Kyle Fedorchak
@kfedorchak
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Advancing cancer care with precision medicine
Boston, MA
Joined August 2012
RT @sama: If you have been following the GPT-5 rollout, one thing you might be noticing is how much of an attachment some people have to sp….
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Nice to see one of my favorite @paulg essays referenced while reading “Range” by @DavidEpstein:. “…don't commit to anything in the future, but just look at the options available now, and choose those that will give you the most promising range of options afterward.”.
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Wild that we have elected public officials who are this openly racist.
Civilized people in America don’t eat like this. If you refuse to adopt Western customs, go back to the Third World.
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RT @RitchieTorres: It is no secret that I have profound disagreements with Zohran Mamdani. But every Democrat — and every decent person — s….
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RT @BarackObama: Thirteen years ago, my administration acted to protect young people who were American in every single way but one: on pape….
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Great educational and entertaining conversation on the classic trio of tariffs, the Democratic Party, and AI.
Democrats are morons for making their brand "profit is bad" from noted lib @zachweinberg . Full episode:
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The paradigm shift from "cancer as a disease of the genome” to “cancer as a disease of the multi-ome” is clearly underway. Thanks again @borauyar @AltunaAkalin for the great crash course on using #DeepLearning techniques to integrate multi-omics data with flexynesis.
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RT @yaireinhorn: 1/🚨WOW! @BeamTx presented promising data from its Phase 1/2 trial of $BEAM-302 in Alpha-1 Antitrypsin Deficiency-AATD, dem….
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Thanks for sharing. It’s nice to see this being covered for a broader audience. For anyone interested in learning more, I highly recommend The Code Breaker by @WalterIsaacson.
1/The Economist has dedicated its excellent Technology quarterly review to the topic of CRISPR & Gene Editing. This review includes many topics which I plan to discuss over several 🧵but I will begin with the most burning issue & that is how this space plans to move forward! 🧵👇
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Will we see large-scale DNA synthesis automation with models like Evo2 as one design step in an elaborate DBTL cycle? Can the build/test steps be fast enough and cheap enough for whole genome applications?.
A socratic dialogue over the utility of DNA language models (Part 2 of 2). link is here: part 2 is out! this time focused on genome generation. i think i tie myself a bit more to Evo 2 specifics to explain this, but i try to explain the context of the.
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Just finished module 1 on AI-assisted data analysis and was amazed by @rolv_io. Made it incredibly easy to visualize gene expression heatmaps and apply ML to methylation data. Thanks @AltunaAkalin and team!.
I'm happy to announce our next computational genomics course for 2025. The deadline for application is January 30th 2025. We will cover:.- AI-assisted data analysis.- Spatial omics analysis .- Multi-omics data analysis. More info is here:
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Awesome! Can lab-in-the-loop also accelerate small molecule design or will players like @IsomorphicLabs have the edge in that space?
endpoints.news
LONDON — Demis Hassabis has no interest in a laboratory. The Nobel Prize-winning artificial intelligence pioneer is betting big on AI’s future in drug discovery. But he’s also grown exasperated at ...
Lab-in-the-loop therapeutic antibody design. At @PrescientDesign @genentech we have spent 3+ years reimagining drug discovery. We built a machine learning system to design and execute experiments. Here's how it works and what we can do 🧵. 1/
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Incredible engineering work to design a polymerase that handles X-NTPs 50X the size of regular nucleotides. Curious if/how the polymerase might be tweaked to accommodate a 5th X-NTP for capturing methylation data.
Roche Xpounds on New Sequencing Technology - my coverage of the new Roche SBX sequencing technology.
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RT @BrianHie: We trained a genomic language model on all observed evolution, which we are calling Evo 2. The model achieves an unprecedent….
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RT @LifeSciVC: Sharing our "Year In Review": Annual Talk On Macro, Biotech, and Atlas. A data-rich, whirlwind tour thru a bunch of pharma….
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RT @NEJM: Frontiers in Medicine, a new monthly review series authored by leading experts, highlights technological advances at the intersec….
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RT @AdamRutherford: My goodness, this is a TERRIFIC piece of writing. The coming epidemics, by @edyong209 in the @TheAtlantic . https://t.c….
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RT @DrSidMukherjee: My second "On Medicine" column for the New York Times (might be a tough read for some)
nytimes.com
What happens when you identify too much with a patient?
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RT @AdamFrank4: Today on NPR. "Certain And Confident: Predicting The Future In A Climate-Changing World." I read the big climate report s….
npr.org
The Climate Science Special Report, released by the White House last week, is a valuable read — it's a primer on how science works when it overlaps with the need to make informed bets on our future.
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