Dr. Kaia Mattioli
@kaia_mattioli
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postdoc, feminist @HarvardMed @BrighamResearch // generally fascinated by genomes // big fan of reality television, good writing, crosswords, & cats // she/her
Boston, MA
Joined March 2009
our work on the molecular differences between transcription factor isoforms is out now in @MolecularCell!. key point: 2/3rds of TF isos differ in important properties like DNA binding & transcriptional activity. many are "negative regulators" that are misexpressed in cancer
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another day in the salt mines (correcting our robot overlords)
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RT @aguirre404: The second half of my PhD work is now on bioRxiv!. We show how data on expression quantitative trait loci (eQTL) relates to….
biorxiv.org
In human populations, most of the genetic variance in gene expression can be attributed to trans -acting expression quantitative trait loci (eQTLs) spread across the genome. However, in practice it...
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RT @lianafaye: This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolu….
biorxiv.org
Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing...
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very happy to hear that the Senate is supportive of life-saving scientific research in America; let's keep making sure that the taxpayers understand how important the NIH is for understanding, preventing, and curing diseases like cancer that don't discriminate across party lines.
The NIH budget would INCREASE by $400m — not slashed by 40%, as Trump proposed — in a proposal by Senate appropriators, says Sen Murray. "Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.
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this is the exact level of drama that i'm expecting from this show btw
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very high stakes today in the lab (floor is down to one tank of LN2 and deliveries are delayed due to a driver's strike) alarms are being silenced. temperatures are being monitored. loyalties are being tested. .
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RT @WUMIN_LAB: @DrAnneCarpenter gene deletion (perturbational or P-strategy) and natural variations (observational or O-strategy) tend to i….
academic.oup.com
Abstract. Although any genotype–phenotype relationships are a result of evolution, little is known about how natural selection and neutral drift, two disti
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RT @aaronmring: T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a r….
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. all in all it definitely helped (sped up what I would otherwise be Google Scholar-ing, let's say) but don't think it revolutionized the process that much. it's much more helpful for coding + answering specific questions + brainstorming ideas than it is for writing imo.
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. so I had to do a ton of prompting to get it to understand the point I was trying to make. that being said, it was pretty useful when I needed suggestions for transitions AND it was super useful for literature searches and fact checking (with me double checking obviously) . .
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been thinking about this -- I just submitted a review, which just so happens to be the only big writing project I've worked on in a post-LLM society. I thought the LLM would help me with writing more than it actually did; imo it wasn't that good at connecting high level ideas . .
Everyone working in a STEM field should read this - ‘writing is thinking’.
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unreasonably sad that Aliquots, our building cafe with an incredible name and decent donuts, closed for good unceremoniously 😭 it's been a reliable snack source for me for 11 years and it's just. boarded up!!
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RT @GenomeBrowser: New ENCODE4 long-read RNA-seq transcripts track for hg38 and mm10. Triplets (e.g. [1,1,3]) indicate start site, exon com….
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RT @ManifoldBio: We're live! Manifold Bio's new website is here: Inspired? We're growing—join us. Special thanks….
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getting weirder and weirder to show up at work every day as a researcher at a university and pretend we're not witnessing the active dismantling of American research universities.
In an unprecedented move, the NIH will soon disinvite dozens of scientists who were about to take positions on advisory councils that make final decisions on grant applications for the US agency, Nature has learnt.
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tell me you're writing a review without telling me you're writing a review
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RT @Mayr_Christine: More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion….
biorxiv.org
More than 2,700 human mRNA 3′UTRs have hundreds of highly conserved (HC) nucleotides, but their biological roles are unclear. Here, we show that mRNAs with HC 3′UTRs mostly encode proteins with long...
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RT @anshulkundaje: One thing that really bothers me with the new "virtual cell" terminology is that is currently largely focused on a very….
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watching my partner be a dad these past 16 months has been the greatest joy of my life. happy Father's Day @PierceOgdenJ
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