
Nature Mental Health
@NatMentHealth
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A new online-only hybrid @NaturePortfolio journal publishing research from the breadth of sciences exploring #mentalhealth and mental health disorders ๐ฟ
Joined February 2022
๐ฆOur May issue is now live!๐ฆ. ๐๏ธTake a look at our new articles on #OCD, #depression, hearing loss, loneliness, #psychedelics, schizophrenia & more!.Cover design: @Marina_C_Spence.
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โก๏ธ Bridging the neurology-psychiatry divide: A new Comment by @AgustinMIbanez & @erzimmer highlights shared dimensions between psychiatric & neurological disorders and calls for a more integrated approach ๐.
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๐ฅณWe are thrilled to announce that our first issue is live! Don't miss out and click below to read our content on psychosis, depression, suicide, brain morphology and more!๐พ๐ฅ#mentalheath #launchingday ๐.
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๐Our June issue is live!๐. We celebrate #PrideMonth ๐ณ๏ธโ๐๐ณ๏ธโโง๏ธand bring a collection of pieces on LGBT+ #mentalhealth, #ADHD, #depression, #psychopathy, psychological therapy, premenstrual disorders & many more! Cover art by @Marina_C_Spence. Check it out ๐.
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๐ซOur March issue is now live!๐บ.We celebrate #LivedExperience and bring a collection of research, news & opinion pieces on #depression, #schizophrenia, substance use disorders, disruptive behavior disorders, and more ๐.Cover by @Marina_C_Spence
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๐Our July issue is now live!๐. We feature 2 articles on #Mindfulness-based interventions and bring a collection of pieces on #PTSD, #COVID19 & mental health, minor #hallucinations in Parkinson's disease & much more๐ฟ. Cover art by @Marina_C_Spence.
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๐ผ Our May issue is now live!.We celebrate #MentalHealthAwarenessMonth and bring a collection of pieces on #Autism, #psychopathology, adolescent mental health, #LongCovid and many more ๐.Beautiful cover art by @Marina_C_Spence .
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#NMHpicks| ๐ง A new study published @NatureNeuro by @amandambuch et al. reveals 4 subtypes of #autism spectrum disorder linked to distinct molecular pathways ๐.@jakob_seidlitz @WCMPsychiatry
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๐ง Using lesion network mapping, @shansiddiqi @IsaiahNeurology et al. have identified a white matter lesion network for #depression in people with #MultipleSclerosis. Read the article published in our ๐ฅ issue ๐
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๐ขDo #mentalhealth disorders share similar brain networks? .A new transdiagnostic study from @MeikeHettwer et al. shows coordinated connectomic, cytoarchitectonic, and functional cortical alterations across six conditions. @sofievalk @HHU_de @NatureComms.
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โจ๏ธ off the press: A new clinical trial by @LucaCocchi78 et al. shows no difference between targeted frontal pole ๐ง stimulation and sham in reducing #OCD symptoms or frontostriatal connectivity ๐.@FunctionOfL @AndrewZalesky @BjornBurgher @DrBreaky .
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๐ปOur November issue is live! ๐ป .We bring a diverse collection of articles exploring the different external factors that may affect #mentalhealth such as #light exposure, #gutmicrobiome , #urbanicity & many more! ๐๐. Cover art by @Marina_C_Spence. ๐.
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๐ฃA new study from Martin et al. shows that #insulin regulates serotonergic (5-HT) neuronal activity in the dorsal raphe via the 5-HT1AR and mediates #emotional behaviors in male mice๐ญ. @XavierFio, @NutriNeuro, @lab_cota, @Neuro_Bordeaux @molpsychiatry.
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๐ This amazing study describes newly developed 5-HT2AR agonists with potent antidepressant activity and no psychedelic effects ๐ @Nature.@Anat_Levit @ellman_lab @zenbrainest @BShoichet @LabSkiniotis @nellie_nicole @KuglaeK @XBarrosAlvarez @PsychoMouse
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๐ @Margarita_KP et al. show that time spent on #socialmedia has minimal effect on adolescent mental health. Others factors like #bullying, lack of family support and school work dissatisfaction play a larger role ๐.@Parise_CM @neilhumphreyUoM.
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๐How did you wake up today? .๐ข@RaphaelVallat et al. identified four modifiable factors (sleep, physical activity, food consumption and blood glucose response) that affect morning alertness ๐ด. #sleep #mentalhealth .@sleepdiplomat @UCBerkeley @NatureComms.
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๐Editorial| #WorldMentalHealthDay is a reminder that #mentalhealth is not just an individual concern but a collective one, deeply intertwined with the broader pursuit of improved mental health and being, sustainable development, and human rights ๐๏ธ๐ฟ.
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๐ธOur April issue is now live!.We are featuring several pieces that speak to the need for robust and comprehensive social safety nets. Read about #PTSD, #transgender mental health, late-life psychosis, and much more. ๐.Cover art by @Marina_C_Spence .
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๐In this beautiful study published in @NatureHumBehav, @MKFlugge et. al identified 7 ๐ง amygdala nuclei with distinct functional connections to 28 other brain regions that can predict 4 behavioral dimensions related to mental well-being. Worth reading it๐
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Q&A| ๐ข๐We spoke to @jack_turban, a physicianโscientist from @UCSF who directs the Gender Psychiatry Program. He studies the #mentalhealth of transgender and gender diverse youth, with a focus on topics related to public policy ๐ณ๏ธโ๐๐ณ๏ธโโง๏ธ. #PrideMonth2023 .
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๐Using a large dataset of approximately 300,000 individuals from the UK Biobank, Zhang, Deng, Li et al. investigated the relationships between personality traits, brain health, inflammation and metabolites. @WeiFDU .
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๐ฅณ6 months since we launched and we received amazing feedback from the community๐ซ! To celebrate we will highlight the articles that gained the most access so far. From๐ฅ issue we have @shansiddiqi & @IsaiahNeurology's article on Lesion network mapping ๐.
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๐ฅHot off the press @NatureComms: @DrCorinaNagy et al. show concordant cortical transcriptomic patterns in #depression within individual cell types in males and females, although major dysregulated cell types and genes were distinct for each sex.โ๏ธโ๏ธ ๐ .
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#NMHpicks| ๐ง A new exciting study shows that poor body health is a more marked manifestation of mental illness than poor brain health ๐.@yetianmed @DrPhilipMosley @MichelleKLupton @DrBreaky @CropleyVanessa @AndrewZalesky @JAMAPsych .
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๐ง ๐๐ฐ Cash @cashmachine15 et al. show that neuroanatomically heterogeneous findings in depression can be reconciled from a connectomics perspective and that they localize to clinically meaningful brain networks ๐.@PBFitzgerald @INM7_ISN @AndrewZalesky .
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#NMHpicks| ๐๐ง In a new Review in @natrevbioeng, @wtkimberly et al. discuss the advantages of portable, low-field MRI that aims to democratize clinical brain #imaging. @BispMriHku @mghclbb.
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๐๐คWant something good to read over the weekend? Our second issue is out!.We celebrate #BlackHistoryMonth and bring much more on #refugee & #youth mental health, suicide, green spaces & mental health. Click and enjoy๐ .cover by @Marina_C_Spence
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๐งฌ Using a sample of >1M people @AlexanderHatoum et al find genomic loci associated with #addiction risk ๐.@SMCColbert @e_covey_johnson @GitaPathakPhD @spaul1124 @karcher_dr @David_Baranger @Andrew_Grotz @tuckerdrob @RenatoPolimanti @HEdenberg2.
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๐ฃ๏ธOur August issue is live!. Featuring a collection of pieces on #youth #mentalhealth, #obssessivecompulsivedisorder, #eatingdisorders, ๐ณ๏ธโ๐ & violence, motivation & pleasure, e-mental health & many more! . Cover art by @Marina_C_Spence . Don't miss out!๐.
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๐ฃHave you ever heard about @BlackInNeuro? They have the mission to celebrate and empower Black scholars and professionals in neuroscience-related fields. And this week is #BlackInNeuroWeek. Read more about it here ๐
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In a ๐Review, Tiego et al. discuss the adverse effects of phenotypic imprecision for discovering reproducible biological correlates of #psychopathology and provide recommendations to overcome these challenges ๐ฟ. @AFornito @HiTOP_system @MonashUni .
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In this Comment, @lfoulkesy, Emma Fergusson and Shona Reed-Purdis argue that overmedicalisation of young people's distress is disempowering families and community, they bring suggestions to reduce the problem. Read the article here ๐จโ๐จโ๐งโ๐ฆ ๐ .
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๐Eldaief et al. show distinct network-specific metabolic & hemodynamic effects after repetitive transcranial magnetic stimulation of two dorsolateral prefrontal cortex targets ๐ง . @RodBraga @NorthwesternU @MGHMedicine @harvardmed.
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๐ง Using data-driven disease-progression #modeling, Jiang, Wang, Zhou et al. characterized and replicated two distinct โtrajectoriesโ of brain atrophy in patients with #schizophrenia. Click to read๐.
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๐ฃ๏ธ"Beyond tokenism: the influence of lived experience and its future possibilities in mental health science".@GateraGrace and @shuranjeetsingh reflect on the benefits of #livedexperience involvement in #mentalhealth science. Read the Comment๐.
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๐๐It is September already and our new issue is now live!. We highlight personalized psychiatry and feature pieces on #deeplearning, multi-omics & #Schizophrenia, #psychiatric disorders & many more! . Cover art by @Marina_C_Spence. Read our content ๐.
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The highlight of our ๐ฅissue is this elegant paper from @AlexanderHatoum et al. that used a sample of more than 1 million individuals to identify genomic loci associated with general and substance-specific #addiction risk. ๐ง ๐งฌ.Read the article๐.
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What is the relevance of stress & #mentalhealth to immunology? .Biltz et al. report the clinical significance of repeated social defeat in mice๐ญ as a model of stress and discuss its effects on the neuroimmune system. @GodboutLab_OSU @OSUWexMed @NatImmunol.
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๐ฃ Drinks over company? In a new study in @npp_journal, @NathanJMarchant et al. show that rats choose #alcohol over social reward and present how #social factors affect alcohol abuse ๐๐ธ #addiction .@NeuroAllison, @AnatNeu_Ams, @amsterdamumc. Link ๐.
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๐จโ๐ป There has been a huge rise in predictive modelling to facilitate a ๐ฅ personalized approach for treatment of mental illnesses. What should one consider when developing ๐ง brain-based models? Read ๐ this excellent ๐ by @elvisha9 @bttyeo @AvramHolmes .
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We're celebrating #BlackHistoryMonth and spoke about it with @keanan_joyner Assistant Professor of Psychology @UCBerkeley. Read our full editorial ๐ by @BekRx here ๐.
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๐Our October issue is live! ๐ . We celebrate #WorldMentalHealthDay2023 and the theme "#Mentalhealth is a universal human right" ๐๏ธ. Read pieces on #depression, #PTSD, substance use disorders & many more!. Cover art by @Marina_C_Spence. Click below๐.
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Out today published on @molpsychiatry: a systematic umbrella review of the evidence around the serotonin theory of depression. The conclusion: the evidence to date do not support the theory. Tell us your thoughts๐.
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#NMHpicks ๐ฅ In this new cool study @loopyluppi et al. show how 10 mind-altering drugs engage the brainโs neurotransmitter landscape to exert their effects on ๐ง function ๐.@JustineYHansen @RCarhartHarris @LeorRoseman @neurodelia @misicbata @estamatakis.
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๐ฅ A new meta-analysis from @camillalnord et al shows that acute augmentations, i.e. interventions to enhance the therapeutic impact, when added to psychotherapy can reduce the severity of #mentalhealth problems ๐ง .@AliciaJ_Smith @TimDalgleish.
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News&Views| ๐@athinara23 & @NikosDaskalakis discuss the new paper from @LaniusRuth's lab on the neurobiology of dissociation in post-traumatic stress disorder ๐ง . #PTSD #fMRI .
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๐จ@PsychMarwaha et al. summarize the effects of novel and emerging treatments for #depression (rTMS, ketamine, anti-inflammatory agents, psilocybin & brexanolone) and discuss their clinical use๐ง . In @TheLancet. @RachelUTG @EdPalmer5 @IMH_UoB @UoB_SoP.
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โจResearch Highlight| We spoke to @castren_eero from @helsinkiuni regarding their new publication in @NatureNeuro. The study reveals #psychedelics induce neuroplasticity and antidepressant-like effects by directly binding to BDNF receptor TrkB in mice๐ญ๐ง .
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๐ฃ There is a bias in considering ๐ #aggression as a male behavior. ๐ป In a new @npp_journal podcast episode @GoldenNeuron talks about a fascinating study from his and @ScottRusso_CAN labs showing females to have a qualitatively distinct aggression. ๐๐.
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#NMHpicks | In this interesting paper @AlexisWhitton et al. show that anhedonia and its neural correlates are prominent predictors of quality of life in people with mood disorders ๐.@ak_poorni @avrutherford @ManonIronside @Dan_Foti @DiegoPizzagalli
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๐ก Using #MRI and connectome-based predictive modelling, @Mengxia_Gao & colleagues show that ๐ง connectivity data can predict #suicide risk in patients with late-life #depression .@nmlwong @HKUniversity .
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What is the contribution of genetics to precision #Psychiatryโ.๐@oleaandreassen et al. discuss key findings in psychiatric genetics & how these can affect current and future applications. @guyhindley @FreiOleksandr @olavsmeland @UniOslo @WPA_Psychiatry .
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๐Mandelli et al. identify early snapshot subtypes of #autism spectrum disorders and propose a predictive model for developmental trajectories in non-verbal cognitive, language & motor domains. @mvlombardo @LAND_IIT @IsottaLandi @UCSD_ACE @IITalk.
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Niews&Views| @VickyLeavittPhD explains the recent paper of @shansiddiqi, @IsaiahNeurology and colleagues and discusses the research shift towards circuits & networks๐บ๏ธ, opening new avenues for brain disease treatments ๐ง .
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๐ฃNew Tweetorial explaining this cool article by @doctorveera et al. about the genetic influence on age at first #ADHD ๐ง ๐งฌdiagnosis. Published on @NatureGenet check it out๐.
Please to inform that my postdoc work with my wonderful supervisors @DemontisDitte and @AndersBorglum is now published in @NatureGenet . This paper marks an important advancement in the ADHD field. ๐งต .
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๐ก In a longitudinal study of Syrian #refugee children, McEwen, @cbiazoli et al. find daily exposure to stressors to be the factor most strongly associated with mental health problems. Learn more ๐.@taniabosqui @michaelpluess
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๐ชท๐งโโ๏ธGalante et al. performed a systematic review and meta-analysis using individual participant data from RCTs evaluating #mindfulness-based programs for adult #mentalhealth promotion in non-clinical settings.@MSSatUoC & the CoMinT ๐๐ชท.
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โจ๏ธIn a new systematic review and meta-analysis @ron_gdt, @RicardoANajera et al. suggest deep brain stimulation as a treatment for obsessive-compulsive disorder and comorbid #depression symptoms. #DBS #OCD.@SameerShethMD @BShofty @BCMNeurosurgery @JNNP_BMJ.
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๐๐ "Going Down The Psychoactive Rabbit Hole": In this podcast Bryan Roth @zenbrainest discusses psychoactive drugs, their role in therapeutic purposes and the unanswered questions surrounding psychedelic research ๐๐.
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๐We launched our 1st issue one month ago!๐ฟ.Would you like to hear which paper from our ๐ฅ issue is the most visited so far? .โLesion network localization of #depression in #MultipleSclerosisโ by @shansiddiqi, @IsaiahNeurology and colleagues.
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๐ขDo #psychedelics have therapeutic effects?๐.@kwanalexc et al. provide an in-depth overview of psychedelics chemistry and mechanisms of action and discuss current limitations/future directions. In @NatureNeuro. @DEOlsonLab @KatrinPreller @zenbrainest .
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๐ขIn a new study in @NatureNeuro, @LeonieKoban et al. used #MachineLearning to discover an #fMRI-based neuromarker that tracks the intensity of drug and food #craving ๐
๐ง . @torwager @hedykober.
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๐Just out! A new double-blind placebo-controlled study by @ETagliazucchi & colleagues published @Transl_Psych shows that #microdosing with #psilocybin mushrooms produces no benefits for well-being, creativity and cognition. Share your thoughts!.
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โ๏ธThis Review article summarizes the advances in #personalizedmedicine and #drugdiscovery in #psychiatry and suggests a framework for the development of clinically relevant biological subtypes in the field. ๐ read it here.By Zhang et al.
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โจIt is time for our final issue for 2023 โจ. We bring a diverse collection of articles exploring #substanceusedisorders, #PTSD, #depression, #suicide, #GutMicrobiota, #psychedelics & many more!. Cover art by @Marina_C_Spence . Check it out! ๐.
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โก๏ธ Our February issue is live! We celebrate #BlackHistoryMonth and bring a collection of research, news & opinion pieces on #suicidailty, #refugee & youth mental health, #stress resilience, ๐ณ green spaces and more ๐.A beautiful cover by @Marina_C_Spence.
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๐คณIn this comment for @molpsychiatry, @dsquintana and @ChrisMontag77 discuss why and how the field of molecular psychiatry should use digital phenotyping, popular in public health and psychological sciences, to enrich their research outcomes. ๐ฑ๐ง ๐
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๐Comment| @Dalla_Christina discusses clinical and preclinical #mentalhealth research needs to take sex and gender under consideration for the development of more efficient and safer treatments for all individuals ๐๐ง . @uoaofficial @EUBrainFdn.
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#NMHpicks| Wearable ๐ด sleep-measuring devices are not affordable or accessible to the majority of people. A new study by Langholm et al. shows the potential of ๐ฑ smartphone-based #DigitalPhenotyping to get scalable data ๐.@JohnTorousMD @npjMentalHealth.
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โจ๏ธ๐ญ Have you ever wondered about the reliability of murine behavioral tasks of #anxiety? .@MariannaRosso1 et al. call for a revision of such tests and suggest developing more predictive tests to measure anxiety-like behavior in mice. @HannoWurbel @unibern.
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๐Drug repurposing: MR receptors antagonist drug usually prescribed for hypertension and heart failure looks promising to treat alcohol use disorder โค๏ธ๐๐ง Read this cool study by @MehdiFarokhnia et. all published last week on @molpsychiatry to learn more๐
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๐ #Autism is diagnosed more often in men than women. Do women require greater liability to manifest autism? In this very interesting ๐ @NeuroCellPress the authors argue against the liability threshold model ๐.@joeddougherty @tycheleturner @GutmannLab .
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๐ฃThis new awesome study shows that ๐ด sleep loss differentially affects women and people with obesity. Check out why night shifts could hit these groups harder ๐๐ง ๐.@dutchessofsleep @sleep_advocate @andrealessa @NicholasAshton @elisa_meth @Transl_Psych .
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@DrNirLipsman et al. found positive results on this phase I pilot trial on Deep Brain Stimulation of the nucleus accumbens for the treatment of severe alcohol use disorder. Read the immediate communication here ๐
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The effects of neurostimulation depend on brain state. This has major implications for therapy and research. Find out why in this wonderful review by @clairebradleyh @AbbeyNydam @PaulEDux @jbmattingley published in @NatRevNeurosci .
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๐ฃWe would like to welcome our newest editor, Ioannis Bakoyiannis! Ioannis (aka John) is joining us after working as an Associate Editor at @LA_NatRes. He conducted his PhD at @univbordeaux in Neuroscience & Nutrition. You can follow him at: @Ibakoyiannis
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โจ๏ธHot off the press: @StellaLab11 from @UWMedicine discusses the differential mechanisms of action and bioactivities of #Cannabis products, ฮ9-tetrahydrocannabinol (THC) & cannabidiol (CBD), and their effects on brain functions๐ฟ๐ง . In @NeuroCellPress.
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๐๏ธOur #Editorial this month is about #youth mental health. We argue that research into the identification of risks for developing #mentalhealth disorders and early intervention in young people is crucial for curtailing the youth mental health crisis. ๐.๐.
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#NMHpicks| @carinacarbiaC et al. show a link between the gut #microbiome and binge drinking in adolescence and associate the gut microbiota composition with social cognition, impulsivity & craving behaviors๐
๐บ. @eBioMedicine @jfcryan @Pharmabiotic .
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๐ฅ Hot from the press! ๐คฐ Pregnancy may cause changes in maternal ๐ง brain structure and function which correlate with mother-child bonding ๐คฑ Check out this cool work by Hoekzema et al. @NatureComms ๐.@h_v_steenbergen @EACrone .
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๐๏ธIn this Q&A we spoke to @ckieling, assoc prof of child & adolescent psychiatry @ufrgsnoticias. We spoke about his work on identifying #depression early in #adolescence (the IDEA consortium) bringing a #globalhealth approach to the topic. Read more ๐.
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๐ฃ๐ง Chronotherapeutics, a non-pharmacological approach, as a treatment for depression: read this new @Nature Outlook piece on why ๐ด sleep, ๐ light and circadian rhythms matter ๐.@DeWeerdt_Sarah @alizaws @McClungColleen @ollen44 @mspitschan .
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๐งช This fascinating work shows that exposure of ๐ง brain cells to serum from #COVID19 patients with #delirium increases cell death and reduces neurogenesis ๐.@ABorsini @VernonLab_KCL @ParianteLab @Gargi_Mandal_ @thudrine @NCNDgroup_KCL @NIHRMaudsleyBRC .
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Published this week in @Nature a study showing the modulatory role of neurotensin in orchestrating valence assignment in the amygdala. Read the article here ๐ .and ๐you can hear the main findings explained by the authors @kaymtye @haoli1988 .
Salk scientists Kay Tye @kaymtye and Hao Li @haoli1988 discuss their recent discovery in @Nature. Their findings uncover why some people are more likely to retain negative emotions than positive onesโas can occur with anxiety, depression or post-traumatic stress disorder (PTSD)
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๐๐ง ๐งฌ This Tweetorial explains a terrific new paper from @dr_appie @michelnivard et al @NatureGenet. Simply controlling for geographic location in GWASs reduces heritabilty for socioeconomic status traits, such as education & income. Unroll ๐งต๐.
We tend to reward people with certain genetic propensities with better environments (higher SES ๐ฐ). This results in gene-environment correlations that make society more unequal and further complicate studying human genetics. Out now in @NatureGenet: ๐งต๐๐ฝ
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๐ Voice-hearing isn't always pathological. Kids can hear their imaginary companions ๐ฆธ, writers - voices of their characters ๐ต๏ธ But it can also be a disabling experience in #mentalillness. Read this wonderful review @NatRevPsych๐.@pmoseley89 @cfernyhough.
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#NMHpicks| @sharma_ashish_2 et al. developed an AI tool, where the human is in control with AI providing input. This tool enables #mentalhealth workers respond more empathically to those seeking help. In @NatMachIntell. @iwylin @electrotipe @timalthoff .
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๐Using meta-analytic techniques, authors report patterns of aberrant #brain activity associated with differences in neurophysiology and #cognitive & behavioral regulatory mechanisms in men diagnosed with pedophilic disorder๐ง . @timmpoe @RWTH.
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๐คWhat do you think about giving a more personal touch and naming exactly who did what in your paper? Read the Comment from @OdedRechavi & @PavelTomancak out @NatRevMCB and tell us your opinion! ๐.
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๐๐Zhao et al. used UK Biobank data to examine the role of lifestyle factors in #depression. They conducted multiple analyses and estimated underlying mechanisms related to brain structure, immunometabolism and genetics.
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๐@HVoetterl et al. examine the application of โBrainmarker-Iโ on predicting remission to therapeutic noninvasive neuromodulation protocols in #depression. @Sack_BSClab @hanvdij @Brainclinics @MaastrichtU.
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๐๐@QasimEtal et al. identified the causal and translational potential of neural activity in the hippocampus-amygdala circuit for promoting emotional #memory during encoding๐งฉ๐ง . In @NatureHumBehav. @uma_r_mohan @joelsteinmd @neurojosh @IcahnMountSinai .
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โจ๏ธHot off the press: In a new Comment, @KSBhui, @SaniaShakoor et al. discuss how creative arts and digital interventions may benefit #mentalhealth in young individuals with adverse experiences in childhood ๐จ๐ง . In @NatureComms. @Kurly_Kaela @QMUL.
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#NMHpicks| In a new Review in @NatRevPsych, Kleiman et al. summarize advanced technologies and statistical methodologies that are used to understand, predict and prevent #suicide and suicidal thoughts ๐จ. @RutgersU, @ODU, @harvardmed.
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