justin cisar
@jcisar
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father, PhD scientist. #scienceworkssometimes
East Coast, USA
Joined June 2011
One of my close friends Jason Thomas is missing. If you see him or know anything, please reach out.
facebook.com
We are trying to locate Jason Thomas, who was reported missing this morning. He was last seen last night at approximately midnight in the area of Murray Street and Chestnut Street. Thomas is a 45...
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Huge thanks to our incredible team @openprotein, especially @timt1630. This is just the beginning of AI systems that truly understand protein biology. I can’t wait to see what the community can do with these models. 13/13
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This work gives us confidence in combining ADME models to calculate early human dose predictions and is being utilized in J&J discovery projects to help advance projects and facilitate decision-making.
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Using a clever approach, Dries and the team demonstrated that the models we evaluated and propagated error allowed for ranking of compounds with 10-fold resolution. In the early drug discovery stage, this is very useful!
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Thus, we focus on a method called 'early human dose prediction,' which uses ADME machine learning model parameters as input. This work addresses a key problem: If each ADME model has error, how does that impact the confidence around early human dose prediction?
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Individual models for preclinical ADME parameters such as clearance, volume of distribution, and oral bioavailability are valuable, but what really matters is the overall effect in vivo and how it could translate to humans.
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I am happy to share our efforts in validating an early human dose prediction method that can be used at the point of design.
pubs.acs.org
Human dose prediction (HDP) is a useful tool for compound optimization in preclinical drug discovery. We describe here our exclusively in silico HDP strategy to triage compound designs for synthesis...
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I am happy to share our efforts in validating an early human dose prediction method that can be used at the point of design.
pubs.acs.org
Human dose prediction (HDP) is a useful tool for compound optimization in preclinical drug discovery. We describe here our exclusively in silico HDP strategy to triage compound designs for synthesis...
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Can we already start thinking about dose at the point of design? We discuss how we try to tackle this challenge and take a closer look at the impact of the accuracy of individual predictions. https://t.co/CH7f2XuQI8
pubs.acs.org
Human dose prediction (HDP) is a useful tool for compound optimization in preclinical drug discovery. We describe here our exclusively in silico HDP strategy to triage compound designs for synthesis...
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Great event!
Last week, myself and Riley Svec (Global Discovery Chemistry at JnJ) had the absolute privilege to co-chair the 2024 JnJ Graduate Research Symposium and host 11 fantastic young chemists at our Spring House, PA Campus. All the students gave phenomenal talks and @KozlowskiMarisa
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Last week, myself and Riley Svec (Global Discovery Chemistry at JnJ) had the absolute privilege to co-chair the 2024 JnJ Graduate Research Symposium and host 11 fantastic young chemists at our Spring House, PA Campus. All the students gave phenomenal talks and @KozlowskiMarisa
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📢 one-day free Symposium on Therapeutic Peptides at J&JIM campus in Beerse 🇧🇪. From peptide synthesis to new advances in oral delivery & cell permeability, we will discuss success stories and future perspectives with leaders from academia and industry 👉 https://t.co/doNXShO9Rr
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I am more worried about AS (artificial stupidity) than AI: there is plenty of dumb things that we have said or written that the large language models may be training on.
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Check out our recent paper where we take diols and bromoalcohols to form strained bicyclic, fused, and spirocyclic compounds through a new concept, couple-close. Big thanks to our collaborators at Janssen Pharmaceuticals at Spring House! https://t.co/qdKaGWvv5L
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Super excited to have our invited review online at @ChemCatChem ! Was a fun collab with @molandergroup André Charette, Todd Marder, Léa Thai-Savard and Jiefeng Hu reviewing some recent cyclopropanation chemistry (my favorite motif!) Check it out! https://t.co/F0A83Wn1Uz
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Today is paper day! THRILLED to share the 1st paper from our PCI collab with @MacMillan_Lab on radical annulation chemistry in @Nature . Was fantastic getting to work with Alice & Christian, two amazingly talented young chemists as well as partnering w/ Callie Bryan in
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Christopher T. Walsh: A Prolific Scientist, Effective Academic Leader, and Responsive Mentor Check out the recent In Focus article from #ACSChemBiol associate editor Hening Lin diving deep on Walsh's life and work ➡ https://t.co/5yAphyV1pu
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The new SureChEMBL is out! https://t.co/KoJUzFaCDJ
https://t.co/T12xVp6Ofy
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I'm humbled and grateful to step into this role starting next year. I'm speechless to know that @AcsMedi knows my X/Twitter name 🤩.
We are thrilled to introduce the newly elected MEDI Executive Committee members! @NikkiG_Conshy will Chair the Long Range Planning Committee in 2024 and is the Vice-Chair Elect. @conway_group will take on the role of division Treasurer.
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