Jakob Seidlitz
@jakob_seidlitz
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Perpetually curious about human development/disease 🧠 🧬 @ UPenn/CHOP. Views my own.
Kensington, MD
Joined August 2016
❗️NEW PREPRINT❗️. Brain size varies ~2-fold across adults, ~100 fold across primates, and nonlinearly changes across the lifespan. How is this reflected at the molecular level?. Thread👇.
biorxiv.org
Human brain size increases dynamically through early development, peaks in adolescence, and varies up to two-fold among adults. Although previous studies have elucidated changes in brain size across...
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🧠 our new/expanded brain charts from >138,000 people‼️Gargantuan effort with @lenadorfschmidt @Aaron_A_B @rai_bethlehem.
Charting structural brain asymmetry across the human lifespan #biorxiv_neursci.
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RT @biorxiv_neursci: Charting structural brain asymmetry across the human lifespan #biorxiv_neursci.
biorxiv.org
Lateralization is a fundamental principle of structural brain organization. In vivo imaging of brain asymmetry is essential for deciphering lateralized brain functions and their disruption in...
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RT @biorxiv_neursci: Comparing Brain-Behavior Relationships Across Dimensional, Tail-Sampled, and Propensity-Matched Models .
biorxiv.org
Large population cohorts are needed to perform brain-wide association studies (BWAS), with evidence that sampling from the tails of a distribution increases effect sizes and improves reproducibility....
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RT @meharpist: How can we increase the replicability of brain-wide association studies in a rigorous way? A @Nature paper by @kaidikangkk….
nature.com
Nature - Optimizing study design is critical for increasing standardized effect sizes and replicability, and the features that increase replicability in cross-sectional and longitudinal brain-wide...
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RT @melissaneuro: ⚡️New #preprint alert ⚡️.We show that #brain aberrations are highly heterogeneous after #preterm birth, and that there ar….
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RT @lenadorfschmidt: Absolutely delighted to see our review of structural MRI brain similarity networks out! The culmination of months of e….
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RT @NatRevNeurosci: Structural MRI of brain similarity networks — a Review by Isaac Sebenius, Lena Dorfschmidt, Jakob Seidlitz, Aaron Alexa….
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RT @kaidikangkk: ✨Our paper, published in @Nature today, investigated how we can leverage study designs to improve the replicability of bra….
nature.com
Nature - Optimizing study design is critical for increasing standardized effect sizes and replicability, and the features that increase replicability in cross-sectional and longitudinal brain-wide...
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RT @FamiliarAriana: Our recent publication and open source release of a de-identification tool to protect patient privacy while empowering….
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RT @cedricboeckx: Great study by @garedaba @StuartJoldham @jakob_seidlitz and colleagues, linking molecular and anatomical descriptions of….
nature.com
Nature Communications - The third trimester of human gestation is characterised by rapid increases in cortical surface area. Here, authors show that increased rates of cortical expansion are...
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RT @sha_zhiqiang: Multimodal data from 98 individuals: neuroimaging, genetics, dendritic spine morphometry, proteomics, and gene expression….
nature.com
Nature Neuroscience - Integration of postmortem molecular and dendritic spine morphological measurements enables the detection of microscale molecules associated with person-to-person variability...
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RT @NatureNeuro: Multimodal data from 98 individuals: neuroimaging, genetics, dendritic spine morphometry, proteomics, and gene expression;….
nature.com
Nature Neuroscience - Integration of postmortem molecular and dendritic spine morphological measurements enables the detection of microscale molecules associated with person-to-person variability...
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RT @_JakeVogel_: It was such a special experience to see this groundbreaking paper in the making. The paper examines, among other things, a….
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RT @sattertt: Wooo! Awesome new work from Kevin Sun integrating personalized functional networks, genomic risk, and clinical psychopatholog….
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RT @Kevin_Y_Sun: How are genetic risk for mental illness, personalized functional brain networks, and overall psychopathology related durin….
medrxiv.org
Importance Functional brain networks are associated with both behavior and genetic factors. To uncover clinically translatable mechanisms of psychopathology, it is critical to define how the spatial...
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RT @TingsterX: Curious about human brain development through an animal model? 🧠🐒Check out our new preprint on Brain Charts of the Rhesus Ma….
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RT @MilhamMichael: Can lifespan brain charts from rhesus macaques inform our understanding of neurodevelopment across species? A new prepri….
biorxiv.org
Recent efforts to chart human brain growth across the lifespan using large-scale MRI data have provided reference standards for human brain development. However, similar models for nonhuman primate...
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RT @will_snyder98: Our paper is now out in Neuron! @NeuroCellPress (details from preprint thread below, now with more results and container….
cell.com
Snyder et al. develop measures of human cortical folding, revealing an axis of linear to complex sulcal shape across the adult cortex. This axis predicts the phased emergence of sulci in utero and...
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RT @_mgardner_: Thrilled to share our preprint introducing ComBatLS, a new data harmonization method that preserves covariates’ (e.g. age a….
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RT @medrxivpreprint: Assessing CT-based Volumetric Analysis via Transfer Learning with MRI and Manual Labels for Idiopathic Normal Pressure….
medrxiv.org
Background Brain computed tomography (CT) is an accessible and commonly utilized technique for assessing brain structure. In cases of idiopathic normal pressure hydrocephalus (iNPH), the presence of...
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