Jacquelyn Wright
@jacquelyn_wrong
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Joined June 2021
Excellent work from my grad student, now postdoc @Roisin_OBrien_ and key lab members @jpkbravo @GraceHibshman @jacquelyn_wrong all @TexasScience! Structural snapshots of R-loop formation by a type I-C CRISPR Cascade
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Back to classical Cascades. Fantastic grad student @Roisin_OBrien_ with @jpkbravo, @GraceHibshman, @jacquelyn_wrong @TexasScience show how the PAM binds and non-target strand is anchored by base stacking, and how not 1 but 2 anti-CRISPS turn Cascade off!
biorxiv.org
Cascades are RNA-guided multi-subunit CRISPR-Cas surveillances complexes that target foreign nucleic acids for destruction. Here, we present a 2.9-Å resolution cryo-electron (cryo-EM) structure of...
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Congrats to all @UTexasILS @NSF #GRFP awardees! @jacquelyn_wrong, @TCordovaBio, Valeria Garcia of @LuLabUT, Brianna Flynn & Olivia Smith of @vagheesh lab. 🥳 Honorable Mentions go to @McCool_Seamus, @bugcatcherlaila, @KendraMaclaine 🙌
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