CRISPR MEMES
@CrisprMemes
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Nobel Prize-winning memes
hypersaline lake metagenome
Joined March 2021
being a bacterium wouldn't be all bad. for one, you'd probably have your own CRISPR system .
time.com
Pulitzer Prize-winning author and doctor Siddhartha Mukherjee on the power of cells and how they shape us
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in these unprecedented times, it's heartwarming to see people doing what really matters; abiding by arbitrary CRISPR naming conventions
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if you've also been here, this is the paper for you!!! super cool that less (guide RNA) = more (on-target) edits!
We’re excited to share our story on CRISPR-driven editing in bacteria now on bioRxiv! Check it out here:
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it's a friendly & accessible resource, but HOLY HECK the conflation of cas9 as "everything CRISPR" really GRINDS MY GEARS.
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adept alliteration assure authors ample attention.
Conformational Changes Regulate Metal Coordination in the Catalytic Sites of Cas9 #bioRxiv.
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you CANNOT. STOP. the CHOP.
CRISPR can cut DNA and RNA, but did you ever wonder other activities might exist? Today in @biorxivpreprint, we show that the Type III-E Cas7-11 system programmably activates a nearby protease as part of microbial defense. @jgooten @hnisimasu 🧵👇🏼1/9.
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fool me once, shame on you. fool me twice, shame on inadequate spacer acquisition by Cas1-Cas2 (and ancillary) adaptation complexes.
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when you've already solved 15 Cas9 structures, and you do another one just to EVEN FURTHER refine the model of off-target activity
We have updated our bioRxiv preprint on Cas9 off-target activity! What is new you may ask? First of all, much sleeker and better looking figures and readability that make this colossus more accessible!.
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*CSI guy voice*: ENHANCE THAT CAS12A.
Our first work on #CRISPR for sensing is out on @NAR_Open! I am super happy to dive into this field of research in this way. Big thanks to the great collaborators @palermo_lab Prof. Perugino from @CNRsocial_ congrats to @MR_ChemSci @RicciLab @WUR
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when they're a 12 but they don't chop DNA 🤷🤷.
"A naturally DNase-free CRISPR-Cas12c enzyme silences gene expression" - Read more from this @MolecularCell paper here: Carolyn J. Huang, @ben_a_adler, @doudna_lab @UCBerkeley @BerkeleyLab
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In this new work in @NatureBiotech, we show that following CRISPR-Cas9 editing in human T cells, ~5% of the cells treated with the specific TCRα gRNA had chromosomal truncation. A wonderful collaboration between @barzel_adi, @BenDavidLab and @madi_lab.
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few years ago it was engineered cas12a, and cas9 a few years before that.
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yeah BUT we found ONE locus where it's ALMOST as good as SpCas9!!!!!
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we're ALL trying to find the guy that BROKE this POOR PHOSPHATE BACKBONE
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