Isabel Mendizabal
@imendizabal1
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Researcher in cancer genomics and evolutionary epigenomics. @Ikerbasque Research Fellow at @CICbioGUNE
Joined February 2021
🚨 Our latest work is out #GenomeBiology! .A thread on our recent study, co-led with @ArkaitzLab and in collaboration with a fantastic team across institutions. Greatful for the support from.@contracancerINV, @criscancer, @Ikerbasque, and others who made this possible. 🧵.
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RT @ASEICAnews: 📢LAST CALL‼️. TOMORROW‼️. Scientific Abstracts session.20th #ASEICACongress.📅8-10 October (Bilbao). 📍Mark these key dates i….
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5/.This work reveals a metastatic transcriptional program in a therapy-naÏve context, offering insights into the biology of de novo metastatic prostate cancer and opening paths to better stratification and management.
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4/.Our bioinformatic analyses point to SOX11 gene as a key regulator of this program. We validated its role both in vitro and in vivo.
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3/.Using single-cell RNA-seq in two additional cohorts, we mapped this ECM signature to specific cancer cell clusters. These cells engage in aberrant heterotypic interactions with the tumor microenvironment.
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2/.We performed RNA-Seq and network analyses on two independent patient cohorts. We uncovered consistent dysregulation of extracellular matrix (ECM)-related programs in these tumors.
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1/.Less than 10% of prostate cancer patients are diagnosed with metastatic disease at diagnosis, but they account for 50% of prostate cancer mortality. Surprisingly, these primary tumors remain poorly characterized at the molecular level.
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RT @contracancerINV: 👏 Felicidades al Dr. Arkaitz Carracedo , la Dra. Isabel Mendizábal y a todo el equipo de @CICbioGUNE por este importa….
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A real pleasure to be part of this work! 👏 👏 thanks to the whole team for the opportunity, in particular to @eportacangen and @DingLab_WashU!.@CICbioGUNE @Ikerbasque @criscancer.
@eportacangen @CellCellPress @DingLab_WashU A privilege being part of this with all y'all. Learned a ton, and had a great time along the way😙! .Huge thanks to @DingLab_WashU and the team for the opportunity, and special shoutout to @imendizabal1 and @adrigaite for the awesome work here.#CPTAC #proteogenomics @CICbioGUNE.
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RT @BizkaikoHitza: #Astekoa | ‘Fusobacterium nucleatum’ mikroorganismoa ikertzen du Naiara Gutiezek. Bakterio horrek koloneko minbizia izat….
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RT @criscancer: 🔴 Sin palabras después de todo lo conseguido durante estos 15 años. Tenemos mucho que celebrar, sí. Pero lo que sobretodo….
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RT @criscancer: 🔴Empieza un día muy especial. ¡Empieza el #DíaCienciaCRIS25!. Un encuentro único con expertos internacionales e investigado….
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RT @CIBER_ISCIII: Ayer y hoy nuestro personal investigador #CIBERONC está celebrando el segundo retreat de Bioinformáticos 👩💻🧑💻 en La Cri….
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RT @ArkaitzLab: Check out the fantastic conference we are planning in Bilbao, and register soon! @ASEICAnews @EACRnews.@CIBERONC @bilbao_ud….
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RT @Athletic_en: ⚽️ Athletic Club & @CICbioGUNE, football and science hand in hand. The collaboration agreement consists of two key proje….
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RT @CICbioGUNE: #bioGUNE_News | 🎉 We celebrated the first day of #CICbioGUNE’s 20th-anniversary event!. An event reflecting on the past, pr….
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RT @GeroScienceAGE: 📢New Open Access Paper📖.Human brain aging is associated with dysregulation of cell type epigenetic identity by Hyeonsoo….
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Fantastic postdoc opportunity!!👇.
🚨Hiring a #Postdoc!🚨.Join us to explore the preclinical stage of inflammatory diseases with multiomic integration.🌟 Up to 3 years of salary to work on gearing #omics for #precisionmedicine.🌍 Bilbao, #BasqueCountry, #Spain.⏳ Dec 31!.🔗#PostdocJobs #IBD
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RT @Izorbaraka: Gure laborategian doktoretza ondoko ikerlari baten bila gaude. 🔄 Lagundu deialdia zabaltzen, mesedez!!.
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