RT @MinSeoKim_MD: Delighted to share the preprint on the largest obesity GWAS to date!. GWAS from >2 million participants. Key:.✳️13% incre….

RT @MariosGeorgakis: Massive investments in proteomics at population level:.👉UK Biobank now fully funded to proceed with 600K samples (500K….

RT @CICbioGUNE: 🔬 #bioGUNE_Research | #CICbioGUNE @brta_eus advances preventive medicine by combining multi-omic data and bioinformatics. T….

RT @euanashley: Atul Butte died yesterday. The world lost a giant. A big bear of a man. With a huge smile. With love for everyone. With ene….

RT @andganna: Matteo Ferro, a doctoral candidate in my team has a new blog on health data science where he is collecting the most interesti….

Stratify healthy people before disease strikes?.Our new paper 👇.➡️Multiomic > single-omic for stratification.➡️One cluster shows stable (and silent!) molecular risk with no symptoms, across 3 visits.➡️Clusters mirror routine labs: omics for the clinic?.

▶️Assortative mating induces long-range weak LD.▶️It could explain 20 to 40% of SNP heritability for social traits!.❓Crazy idea: could we focus on specific haplotypes to infer ancestral differences in social structure?.(eg. Yamnaya vs. Early Farmers)?.

RT @Iagorlago: Single-cell RNAseq shows significant differences between patients with incidental Crohn's disease vs healthy controls. Just….

First personalized in vivo CRISPR base editing in a human to correct a pathogenic mutation. Lovely! 😘.

Large GWAS for T2D in East Asians, with cool comparisons vs. Europeans. Key findings: "Genetically determined insulin resistance contributes more prominently to T2D in Europeans than in East Asians". Would have loved a comparison across decades!.

RT @AlexTISYoung: In March last year, at the age of 35, I was diagnosed with advanced stage III rectal cancer with a metastasis in my liver….

RT @Iagorlago: So excited to share the publication of the protocol from the EARLY cohort from @geteccu . 🙋350 patients.🏥25 sites.🔬Incidenta….

RT @CICbioGUNE: #bioGUNE_Thesis | Researcher Adrián Gaite Reguero will defend his #PhD thesis:. 📖 “Characterization of the molecular pathwa….

Cool study of response eQTLs 👇.➡️Immune stimulation with bacterial, viral and adaptive triggers.➡️>55% are seen after stimulation. ➡ Most are context-specific eQTL (even with opposite direction), but some due to gene expr. induced (or lost!).

Epic modeling of the proposed 4 stages of IBD epidemic.➡️Now we can assign stages from incidence/prev data. ➡ Reinforces we gotta stop new cases from appearing, specially in places moving to stage 2.➡️ Health justice angle: lack of data blinds us a lot!.

Just learned about p-Tau217 in blood as a potential biomarker to Alzheimer’s 15 years before symptoms 😯.

Polygenic risk score for BMI does not associate with weight loss from GLP1 drugs or bariatric surgery. ▶️Treatment works equally regardlesss of "genetics"?.▶️Genetics of susceptibility ain't genetics of response?.

Recent T1D cases might be showing lower PRS:.▶️diagnosing less "genetic" cases? .▶️changes in genetic architecture due to "new" risk alleles (likely amplification due to GxE)?.▶️changes in disease subtypes?.Gotta think about it! 🤔.#T1D #genomics #PRS.

RT @eportacangen: Finally out at @CellCellPress, our latest contribution to proteogenomics with #CPTAC. The impact of germline variants to….

Assessment of a Polygenic Risk Score in Screening for Prostate Cancer.▶️Targeted screening for men in top 10% of genetic risk (as we can currently measure!) .▶️ 40% had cancer, >50% needed treatment.▶️ 70% missed by current screening guidelines 😠.