RT @HeuckLab: We are hiring! Check Add

RT @chienlab: We are looking for a new colleague to join my department, the focus is on quantitative or structural biology, let me know if….

Thank you Marcin!.

Checkout the recent work from our lab that demonstrates how glucose attached to a protein can direct the protein folding and molecular choreography of nascent chains in the endoplasmic reticulum.

RT @pietro1968: A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint: iScience https://….

And co- and post-translational modifications like glycosylation.

I am saddened by such a tremendous loss. Jeff was incredibly talented in so many ways.

Beautiful work from the Feige lab that beautifully characterizes the elusive protein-protein binding properties of calnexin. Congrats Matthias and colleagues!.

RT @chienlab: If you have any questions, feel free to check out the ad or get in touch! [can you see yourself here?⬇️] .

RT @TobiWalther: This fall the ⁦@FandWLab⁩ is moving to ⁦the #cellbiology department ⁦@MSKCancerCenter⁩. Interested in fundamental, mechani….

Here is an article for the general public we wrote to describe this work:

This is a long-term collaborative study with @gierasch1 and Anne Gershenson from @UMassAmherst and Terry Flotte of #UMassChan that builds off an initial study using SAHA by Balch and colleagues. #ER_literature #glycotime.

Congrats to Haiping Ke and @kpguay28 for their work that shows that a small molecule proteostasis regulatory boosts muscle cell alpha-one secretion, the site of intramuscular injections for gene therapy.

Excited to share our new collaborative preprint from @pietro1968, @zitzmannlab, @kpguay28 and others that describes the discovery of the first inhibitor to the ER quality control sensor UGGT. Something for everyone: crystallography, NMR and cell biology studies! #glycotime.

RT @theNASciences: Elected in 2019, Lila M. Gierasch of @UMassAmherst @UMassBMB is being inducted to the National Academy of Sciences for i….

How ER UGGT recognizes non-native substrates remains a mystery. This exciting collaborative study led by @pietro1968 reports on the structure of UGGT and uses MD to model molecular motions of its 4 thioredoxin domains to provide valuable insight into its interrogation methods.

Thanks Mauri.

Congrats to grad student @_benjamin_adams for developing a glycoproteomics platform to ID natural substrates of key quality control ER folding sensors UGGT1 and UGGT2 and revealing UGGT2’s preference for lysosomal proteins. Good luck on his next endeavor @sshaolab @HarvardCellBio.