3. Supplements: “Fuel your body’s defenses.”. Part 1: Longevity Boosters. • Resveratrol: Found in red wine, it activates sirtuins (longevity genes). • Dose: 1 gram daily, mixed with olive oil or yogurt. • NMN: A precursor to NAD, it boosts energy and repairs cells. • Dose: 1

Rule 3: "Eat less often". Sinclair skips breakfast. Sometimes lunch. Not for weight loss, for cellular survival. Intermittent fasting activates AMPK and sirtuins, turning on the body's longevity pathways.

7. Resveratrol. Red wine's secret weapon, but alcohol cancels the benefits. You need pure, concentrated forms to activate: . • Longevity genes (sirtuins) .• Mitochondrial biogenesis .• Cellular stress resistance .• Anti-aging pathways. The doses in wine are practically

NAD 🔥🔥🔥. - Boosts energy 💥production .- Repairs DNA 🧬 damage .- Slows aging via sirtuins .- Regulates metabolism .- Supports brain health .- Enhances exercise performance . Get it while it lasts. Code SFL10 for 10% off of your order.

Metabolic increases in NAD activate sirtuins & reduce epigenetic noise in embryonic stem cells (ESCs). As evidence, in ESC mixing experiments, the NAD-boosted ESCs derived from a light-haired mouse comprise more % of the pups than untreated ESCs from a darker mouse. Nice link

Resveratrol. One of the most promising compounds in anti-aging research. It activates sirtuins—"longevity genes" that repair DNA and enhance cell survival. Found in red wine, grapes, and berries, it’s nature’s way of slowing the aging clock:

Roles of Sirtuins in Cardiovascular Diseases: Mechanisms and Therapeutics" at

2. Supplements stack. 1. Resveratrol: A compound found in red wine that activates sirtuins, the body’s longevity genes. It helps with anti-aging, inflammation reduction, and cell repair. How to use: Take 1g daily with olive oil or yogurt to improve absorption:

As we get older or sick, our NAD+ levels drop. Yet NAD+ Is crucial for:.-Energy production.-DNA repair.-Sirtuins/gene expression.-Immune function.-Brain functions.-Hormonal health.and more. How is this the case is not hard to understand. NAD+ for example acts as an electron

When you fast, your body activates proteins called sirtuins. These fix damaged DNA and help cells work better––slowing down aging. To activate these longevity pathways, Sinclair typically eats in 8-hour windows (skipping breakfast most days).

Coffee improves literally EVERY molecular biomarker of aging in existence. For instance, it increases sirtuins. These "longevity proteins" control genes that:. ➞ Reduce inflammation.➞ Increase antioxidant support.➞ Support metabolism / mitochondrial function

5) Anti aging. Fasting activates "longevity genes" (sirtuins), which:. • Repair DNA damage.• Slow aging processes.• Reduce chronic disease risk. Animal studies show 30% longer life span. Humans next?. Even high performers like twitter founder Jack Dorsey swear by it

Caloric Restriction and Sirtuins as New Players to Reshape Male Fertility @MetabolitesMDPI .

New study on sirtuins 🧵

New research: NAD+ modulation influences mitochondrial function and cellular senescence pathways | Journal: Aging Cell . Analysis: EGCG exhibits synergistic effects with resveratrol in activating sirtuins, enhancing metabolic regulation.

Resveratrol is still riding the red wine hype train. But let’s be real: Its impact is weak, its absorption is worse, and its half-life is laughable. Stop sipping for sirtuins. Pterostilbene is the real upgrade.

Sirtuins in kidney health and disease

4. Resveratrol. This compound activates longevity proteins. It's found in red wine and certain plants that activate sirtuins. It enhances mitochondrial function and reduces oxidative stress on cells. Sinclair takes it with yogurt to boost absorption.

Pterostilbene is like resveratrol. but evolved:. ✅ 4x better absorption.✅ 7x longer activity in your body.✅ More fat-soluble → deeper cellular impact.✅ Activates sirtuins more efficiently. Science is catching up. So should your stack.