Dr Dayne Beccano-Kelly (UK DRI at Cardiff) is looking for a research associate to join his new lab at UK DRI at Cardiff 🏴󠁧󠁢󠁷󠁬󠁳󠁿. Assessing synaptic activity in Parkinson’s using cutting edge tech - PatchSeq, Optogenetics iPSC & knock-in models 🧠. 🗓️ 20 Mar 👉

7/12 In type 2 diabetes (T2D), beta-cells are impaired. Studies have reported altered single-cell gene expression, but it’s hard to know which are important. #patchseq can help with this by simultaneously studying changes in expression and function…

9/12 Two more things: Lots of data on other cell types. One challenge for electrophysiologists is challenge is the identification of non-beta-cel types. We show #patchseq can help refine models to better identify glucagon-secreting alpha-cells based on their e-phys.

How to attract the attention of your public after a coffee break. Andreas Tolias, you nailed it! #neocortex #brain #rngs19 #patchseq

5/12 To characterize molecular differences that underlie synapse diversity, I established Isoform-Patchseq in collaboration with core facilities at @MIT. Special thanks to @Scientifica_Int manipulator which made my life easy to collect these challenging patch-sep samples!

We are delighted to publish this #Neuroscience #Protocol for #PatchSeq of Small #Interneurons , by Dr. Matthew S. Grubb and colleagues @GrubbLab @dev_neuro .

I’m seeking a research assistant to work on an @mssocietyuk funded project at the @UofGlasgow @iiiglasgow along with @BiottofnI and others. Experience in #electrophysiology and/or primary #cellculture essential. #liveimaging #bioinformatics #Patchseq.

Functional connectome with transcriptomics from Andreas Tolias ! #RNGS19 #patchseq

Our #singlecell #pancreas #patchseq preprint is out: "Pancreas patch-seq links physiologic dysfunction in diabetes to single-cell transcriptomic phenotypes" @bcellorg #QuakeLab #KimLab @czbiohub

Excited to talk at the 32rd Head Group Meeting: Craniofacial & Neural Development @UCLchildhealth in Jan 2020! . I’ll be presenting new work on neuronal polarisation in vivo, also looking forward to hearing the latest on olfactory bulb #patchseq from Marcela Lipovsek @GrubbLab

Meet cell 485105.03.02.01. and follow its epic journey to become data through our large-scale, multi-team #Patchseq pipeline.

1/12 Here’s our paper on the dual e-phys/scRNAseq of >1300 human islet cells. I can’t emphasize enough the massive effort by @XiaoqingDai who patch-clamped ALL the cells and @JoanCamunas who did ALL the sequencing/bioinformatics. #patchseq .

We are soon advertising a position (#postdoc/staff #scientist) in #Data Management, #Computational analysis and/or #Bioinformatics. Help us build a program that combines datasets from cell->tissue->patient!. #biobanking #genomics #physiology #patchseq.

@suresh__jetti and colleagues paper from the lab on PatchSeq approaches to characterize differences in Drosophila tonic-like Ib and phasic-like Is motoneurons is now published in Neuron – check it out from the link below.

Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq.

(1/11) Andrés Crane’s thesis work in the lab with Suresh Jetti using PatchSeq to define the targets and rules for single neuron RNA editing in Drosophila motoneuron subtypes is now available as a preprint:.

Fantastic talk by @LaurenJDonovan from @TawfikLab at the NeuroImmune session at @IASPpain world congress! Huge shoutout to superstar Baccei Lab alum @ChelsieLBrewer for doing some sweet PatchSeq studies in the DRG (crazy hard stuff!)

If #Darwin would have had access to powerful microscopes and #PatchSeq he would have written a second book “The evolution of cell types”. Human brains are not just an expansion in the # of neurons or connections. Neurons have evolved as much as species have.

Hey, do you want to get electrophysiological recordings and transcriptomic data from the same small cells? Tips and tricks and (really) ALL the details in our newly published #Patchseq protocol! @LorcanBrowne @dev_neuro @KingsIoPPN . ⬇️⬇️⬇️.

Our Drosophila larval motoneuron Isoform-PatchSeq print is out! Thanks to @JTroyLittleton and other for their collaboration. Molecular Logic of Synaptic Diversity Between Drosophila Tonic and Phasic Motoneurons