1/12 I am excited to share our study published today @NeuroCellPress. In this study, we described nanoscopic and transcriptomic correlates that underlie synaptic diversity. Thanks to @JTroyLittleton and colleagues.

RT @GenAI_BioReads: @naturemethods @PNASNews 38/ Next paper in this series is #Boltz2 paper that described an open-source AI model that pre….

RT @hb_cell: @suresh__jetti @MarderLab It remains as Gold Standard of neurophysiology once ever since it was invented. Gold does not change….

@MarderLab 8/ Why does single-neuron physiology still matter in the era of #AI and #deep_learning ?.Functional connectivity mapping data collected using patch-clamp physiology might inspire, deep learning experts and AI scientist to design better deep learning algorithms that might advance.

@MarderLab 7/ .Approximately 18% of all drug targets are ion channels, while around 33% target G protein–coupled receptors (GPCRs)—many of which modulate ion channel activity through intracellular signaling pathways. Source:

@MarderLab 6/ Why does single-neuron physiology still matter?.To explore the rich diversity of neurons and synapses in the human brain—an area still vastly underexplored, as highlighted by a recent study from the Peter Jonas lab (Cell Press)—is essential. These fundamental building blocks

5/ Here is an excerpt taken from @MarderLab Marder’s essay

4/

3/.To support this observation, I conducted a quick PubMed search, which reveals a declining trend in research articles employing classic neurophysiology techniques such as patch-clamp recordings.

2/ .As Eve Marder, one of my scientific role model, noted in an essay, the number of trainees choosing to study and practice single-neuron biophysics—covering ion channels, neuronal excitability, and synaptic transmission, the fundamental building blocks of neuroscience—is

1/The Vanishing Art of Single-Neuron Electrophysiology:.In the era of large-scale neuroscience projects, the #AI_neuro_revolution, and increasing automation, the meticulous art of single-neuron electrophysiology is fading—even though it remains foundational to many core concepts

RT @JTroyLittleton: (1/8) New study from Yulia Akbergenova in the lab on how neurons regulate structural and functional maturation of activ….

RT @LongevityPapers: Friends and colleagues often ask, “What are the top 100 important "AI in Biology" papers that provide broad insights i….

14/15 further requested it to draw a diagram of #mitochondria. After multiple prompt trails, this is what I got

13/15 further asked it to draw a diagram of mouse #olfactory_bulb

11/15 further asked it to draw a diagram of #human_spinal_cord

10/15 further requested it to create a detailed accurate diagram of a #Neuron

9/15 I further requested it to create a detailed accurate diagram of a #Synapse_vesicle . Here is the response to my Prompt: Here is the detailed and accurate diagram of a synaptic vesicle, illustrating its structure, including the lipid bilayer, neurotransmitter molecules

8/15 As I was quite unhappy with synapse diagram, I modified my prompt with more details and further requested it to create a detailed accurate diagram of a #Synapse

7/15 I further requested it to create a detailed accurate diagram of a #Synapse

6/15 I further requested it to create a detailed accurate diagram of a biological neural network